Possible causes of rare diseases in relatively small ethnic groups. Questions of mixed pathology and differential diagnosis
Abstract
The presented clinical case is probable case of the Creutzfeldt-Jakob Disease (CJD) from the region of distribution of the Vilyui encephalomyelitis (VEM) in Yakutia. The disease occurs in the form of rapidly progressive, fatal meningo-encephalitis, with positive identification of oligo bands of IgG in the cerebrospinal fluid and meningeal symptoms, but with CJD characteristic MRI neuroimage changes. Such cases, even being single and possibly not related to prion diseases, should cause the attention of the scientific and medical community and require thorough investigation and further study.
About the Authors
V. A. Vladimirtsev
Research Institute of health NEFU
Russian Federation
Russian Federation
Vladimirtsev Vsevolod Afanasievitch, PhD, senior researcher, Head of Department of inflammatory and degenerative diseases of the brain
677010 Yakutsk, Sergelyakhskoe highway 4, bldg.2
phone: +7-914-231-25-99
T. K. Davidova
Research Institute of health NEFU
Russian Federation
Russian Federation
Davydova Tatyana Kimovna, PhD, senior researcher, Research Institute of health NEFU
T. Y. Nikolaeva
MI NEFU
Russian Federation
Russian Federation
Nikolaeva Tatiana Yakovlevna, MD, Head of the chair of nervous diseases and psychiatry
677005, Yakutsk, P. Alexeev St. 83A
phone: +7-914-266-11-14
L. T. Okoneshnikova
Center of Emergency Medical Care (RCECM)
Russian Federation
Russian Federation
Okoneshnikova Lyudmila Timofeevna, Head of the neurological Department of the Republican hospital №2
677005, Yakutsk, P. Alexeev St. 83A
phone:+7-914-285-81-81
N. Yu. Gorokhova
Center of Emergency Medical Care (RCECM)
Russian Federation
Russian Federation
Gorokhova Nadezhda Yurievna - a neurologist
N. V. Luginov
Republican hospital №2-Center of Emergency Medical Care (RCECM)
Russian Federation
Russian Federation
Luginov Nikolai Vasilievitch, MD, Head of the Department of radiology
677005, Yakutsk, P. Alexeev St. 83A
phone: +7-914-223-48-57
L. A. Klarov
Republican hospital №2 (RCECM)
Russian Federation
Russian Federation
Klarov Leonid Alexandrovich, Department Head of MRI of Department of radiology
677005, Yakutsk, P. Alexeev St. 83A
phone: +7-914-300-71-81
D. A. Popov
Department of radiology, Republican hospital №2 – RCECM
Russian Federation
Russian Federation
Popov Dygyn Aleksandrovich - doctor of the MRI
M. M. Popov
Department of radiology, Republican hospital №2 – RCECM
Russian Federation
Russian Federation
Popov Mikhail Mikhailovich, doctor-radiologist of the MRI
677005, Yakutsk, P. Alexeev St. 83A
phone: +7-914-223-48-57
V. L. Osakovsky
NEFU
Russian Federation
Russian Federation
Osakovsky Vladimir Leonidovich, PhD, Senior researcher, Head of genetic laboratory research Institute of health
677010 Yakutsk, Sergelyakhskoe highway 4, bldg.2
phone: +7-924- 870-31-67
T. M. Sivtseva
NEFU
Russian Federation
Russian Federation
Sivtseva Tatiyana Michailovna, PhD, Senior researcher of the Department of genetic laboratory research Institute of health
677010 Yakutsk, Sergelyakhskoe highway 4, bldg.2
phone: +7-914-223-74-32
F. A. Platonov
NEFU
Russian Federation
Russian Federation
Platonov Fedor Alexeevich, MD, Director of the Institute of health
677010 Yakutsk, Sergelyakhskoe highway 4, bldg.2
phone: +7-964-419-58-35
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13.
Review
For citations:
Vladimirtsev V.A., Davidova T.K., Nikolaeva T.Y., Okoneshnikova L.T., Gorokhova N.Yu., Luginov N.V., Klarov L.A., Popov D.A., Popov M.M., Osakovsky V.L., Sivtseva T.M., Platonov F.A. Possible causes of rare diseases in relatively small ethnic groups. Questions of mixed pathology and differential diagnosis. Yakut Medical Journal. 2017;(1):67-71.
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