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Analysis of the clinical outcomes of gastroduodenal diseases in Yakutia depending on the presence of the cytotoxin-associated gene A (cagA) in the Helicobacter pylor

https://doi.org/10.25789/YMJ.2018.63.03

Abstract

In this paper we presented the results of the study of clinical outcomes in patients with gastroduodenal diseases in Yakutia depending on the presence of the cytotoxin-associated gene A (cagA) in Helicobacter pylori genome. The relationship between cagA+ strains and more severe clinical outcomes (erosion and ulcers) in patients with gastroduodenal diseases associated with Helicobacter pylori in Yakutia has been shown.

About the Authors

N. N. Gotovtsev
Federal State Budgetary Scientific Institution “Yakut Science Center of Complex Medical Problems”
Russian Federation

Gotovtsev Nyurgun Naumovich - Scientific researcher, Laboratory of Molecular Genetics

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4

Phone: 89141062015



N. A. Barashkov
Federal State Budgetary Scientific Institution “Yakutsk Scientific Center of Complex Medical Problems”
Russian Federation

Barashkov Nikolai Alekseevich - Candidate of biological sciences, Head of laboratory of Molecular genetics

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4

Phone: 8-(4112) 32-19-81



Т. V. Borisova
Federal State Autonomous Educational Institution of Higher Education “North-Eastern Federal University. M.K. Ammosov “
Russian Federation

Borisova Tuyara Valerievna - student, Institute of Natural Sciences

677000, Yakutsk, Kulakovsky st. 48

Phone: 89644290223



M. V. Pak
Republican Hospital No. 1 National Center of Medicine
Russian Federation

Pak Maria Vladimirovna - endoscopist of the endoscopic department

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4



M. P. Alekseeva
Republican Hospital No. 1 National Center of Medicine
Russian Federation

Alexeeva Mavra Pavlovna - endoscopist of the endoscopic department

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4



N. N. Innokentieva
Medical Institute; Federal State Autonomous Educational Institution of Higher Education “North-Eastern Federal University. M.K. Ammosov “
Russian Federation

Innokentyeva Natalya Nikolaevna - Post-graduate student

677010, Yakutsk, Oyunsky st. 27

Phone: 8-(4112) 36-30-46



K. S. Loskutova
Republican Hospital No. 1 National Center of Medicine
Russian Federation

Loskutova Kiunniai Savvichna - Candidate of Medical Science, Head of the Pathoanatomical department

 677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4



V. G. Pshennikova
Federal State Budgetary Scientific Institution “Yakutsk Scientific Center for Complex Medical Problems”; NEFU
Russian Federation

Pshennikova Vera Gennadievna - Scientific researcher, Laboratory of Molecular Genetics; postgraduate student

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4

Phone: 8-(4112) 32- 19-81



A. M. Rafailov
Institute of Natural Sciences, Federal State Autonomous Educational Institution of Higher Education “North-Eastern Federal University. M.K. Ammosov “
Russian Federation

Rafailov Adum Mikhailovich - Candidate of Biological Sciences, Associate Professor, Department of Biology

677010, Sakha Republic, Yakutsk, Kulakovsky st. 48

Phone: 8-(4112) 49-68-42



S. N. Lekhanova
Federal State Autonomous Educational Institution of Higher Education “North-Eastern Federal University M.K. Ammosov”; Medical Institute
Russian Federation

Lekhanova Sargylana Nikolaevna - Candidate of Medical Science; Associate Professor

677010, Yakutsk, Oyunsky st. 27

Phone: 8-(4112) 36-30-46



S. A. Fedorova
Federal State Autonomous Educational Institution of Higher Education “North-Eastern Federal University M.K. Ammosov”
Russian Federation

Fedorova Sardana Arkadievna - Doctor of biological sciences, Head of the Research Laboratory of Molecular Biology Institute of Natural Sciences

677010, Sakha Republic, Yakutsk, Kulakovsky st. 46



References

1. Novikov D.K. Clinical immunology: tutorial / D.K. Novikov, P.D. Novikov. VSMU, 2006. – P. 392.

2. Association of cagA and vacA Genotypes of Helicobacter pylori with gastric diseases in Estonia / H. Andreson, K. Lõivukene, T. Sillakivi [et al.] // J Clin Microbiol. – 2002. – 40. – P. 298-300.

3. Association of Helicobacter pylori cagA Gene with Gastric Cancer and Peptic Ulcer in Saudi Patients / T. Saber, M.M. Ghonaim, A.R. Yousef [et al.] // J Microbiol Biotechnol. – 2015 Jul – 5(7) – P.146-53.

4. Biofilm and Helicobacter pylori: From environment to human host / A. García, M.J. Salas-Jara, C. Herrera [et al.] // World Journal of Gastroenterology. – 2014. – WJG. – 20(19). – P.5632-5638.

5. Blaser M.J. Ecology of Helicobacter pylori in the human stomach / Blaser M.J. // J Clin Invest. – 1997. – 100. – P. 759-762.

6. Clinical relevance of H. pylori cagA and vacA gene polymorphisms / D. Basso, C.F. Zambon, D.P. Letley [et al.] // Gastroenterology. – 2008. – 135. – P. 91-99.

7. Clinical Relevance of the cagA, vacA, and iceA Status of H. pylori / L.J. van Doorn, C. Figueiredo, R. Sanna [et al.] // Gastroenterology. – 1998. – 115(15). – P. 58-66.

8. Clinical relevance of the H. pylori gene for blood-group antigen-binding adhesin / M. Gerhard, N. Lehn, N. Neumayer [et al.] // Proc Natl Acad Sci U S A. – 1999. – 96. – P. 12778-12783.

9. Effective Methods of Nucleic Acids extraction for Analysis in Molecular Biology (review) / O.S. Antonova, N.A. Korneva, Yu. V. Belov [et al.] // Scientific Instrument Making. – 2010. – T. – 20. – № 1. – P. 3-9.

10. Functional analysis of iceA1, a CATGrecognizing restriction endonuclease gene in H. pylori / Q. Xu, R. D. Morgan, R. J. Roberts [et al.] // Nucleic Acids Research. – 2002. – 30(17). – P.3839-3847.

11. Helicobacter pylori genotypes among patients in a university hospital in Egypt: identifying the determinant of disease severity / F.A. Amer, R.H. El-Sokkary, M. Elahmady [et al.] // J. Microbiol. Infect. – 2013. – Dis. – 3. – P. 109-115.

12. Helicobacter pylori genotypes and expression of gastritis in erosive gastro-oesophageal reflux disease / A. Leodolter, K. Wolle, U. Peitz [et al.] // Scand J Gastroenterol. – 2003. – 38: 498-502.

13. Helicobacter pylori genotypes are associated with clinical outcome in Portuguese patients and show a high prevalence of infections with multiple strains / C. Figueiredo, L.J. van Doorn, C. Nogueira [et al.] // Scand J Gastroenterol. – 2001 Feb. – 36(2). – P. 128-135.

14. Helicobacter pylori iceA, clinical outcomes, and correlation with cagA: a meta-analysis / S. Shiota, M. Watada, M. Osamu [et al.] // PLoS ONE. – 2012. – 7(1):e30354.

15. Helicobacter pylori strain types and risk of gastric cancer: a case-control study / H. Enroth, W. Kraaz, L. Engstrand [et al.] // Cancer Epidemiol Biomarkers Prev. – 2000 Sep. – 9(9). – P. 981-985.

16. Helicobacter pylori vacA, iceA and cagA status and pattern of gastritis in patients with malignant and benign gastroduodenal disease / S. Miehlike, M. Schuppler, C. Frings [et al.] // Am J Gastroentrol. – 2001. – 96. – P. 1008-1013.

17. Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production / Y. Yamaoka, S. Kikuchi, H.M. el-Zimaity [et al.] // Gastroenterology. – 2002 Aug. – 123(2). – P. 414-24.

18. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach / M.J. Blaser, G.I. Perez-Perez, H. Kleanthous [et al.] // Cancer Res. – 1995. – May 15. – 55(10). – P. 2111-5.

19. Jenks P.J. Clinical outcome after infection with Helicobacter pylori does not appear to be reliably predicted by the presence of any of the genes of the cag pathogenicity island / P.J. Jenks, F. Megraud, A. Labigne // Gut. – 1998. – 43. – P. 752-758.

20. Kusters J.G. Pathogenesis of Helicobacter pylori Infection / J.G. Kusters, A.H.M. van Vliet, E.J. Kuipers // Clinical Microbiology Reviews. – 2006. – 19(3). – P. 449-490.

21. Momenah A.M. H. pylori cagA and iceA genotypes status and risk of peptic ulcer in Saudi patients / A.M. Momenah, M.T. Tayeb // Saudi Med J. – 2007. – 28. – P. 382-385.

22. Prevalence of Helicobacter pylori vacA, cagA, iceA and oipA genotypes in Tunisian patients / K.B. Mansour, C. Fendri, M. Zribi [et al.] // Ann. Clin. Microbiol. Antimicrob. – 2010. – 9. – P. 10-16.

23. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection / J. Parsonnet, G.D. Friedman, N. Orentreich [et al.]. // Gut. – 1997. – 40(3). – P. 297-301.

24. Rothenbacher D. Helicobacter pylori and gastric cancer / D. Rothenbacher, H. Brenner. // Gastroenterology. – 2004. – Vol.126. – Issue 7. – P.1927.

25. Suerbaum S. H. pylori infection / S. Suerbaum, P. Michetti. // N Engl. J. Med. – 2002. – 347. – P. 1175-1186.

26. The EPIYA-ABCC motif pattern in CagA of Helicobacter pylori is associated with peptic ulcer and gastric cancer in Mexican population / F.O. Beltrán-Anaya, T.M. Poblete, A. Román-Román [et al.] // BMC Gastroenterology. – 2014. – 14:223.

27. Tummuru M.K. Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production / M.K. Tummuru, T.L. Cover, M.J. Blaser // Infect Immun. – 1993 May. – 61(5). – P. 1799-809.

28. Wroblewski L.E. Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk / L.E. Wroblewski, R.M. Peek, K.T Wilson // Clinical Microbiology Reviews. – 2010. – 23(4). – P. 713-739.


Review

For citations:


Gotovtsev N.N., Barashkov N.A., Borisova Т.V., Pak M.V., Alekseeva M.P., Innokentieva N.N., Loskutova K.S., Pshennikova V.G., Rafailov A.M., Lekhanova S.N., Fedorova S.A. Analysis of the clinical outcomes of gastroduodenal diseases in Yakutia depending on the presence of the cytotoxin-associated gene A (cagA) in the Helicobacter pylor. Yakut Medical Journal. 2018;(3):11-14. https://doi.org/10.25789/YMJ.2018.63.03

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