Research of adiponutrin gene (PNPLA3) in indigenous people of the Republic Sakha (Yakutia) with type 2 diabetes
https://doi.org/10.25789/YMJ.2018.61.02
Abstract
Polymorphism of the I148M Gene of the PNPLA3 Gene was studied in patients with type 2 diabetes of the Yakut nationality. The predominance of the GG Genotype (58.5%) with a G-allele frequency of 74.1% was revealed. The normally functioninG protein of the PNPLA3 Gene reGulates the activity of triGlyceride hydrolase and lysophosphatidic acid acyltransferase. It is likely that the hiGh frequency of the mutant allele G in the Yakuts with type 2 diabetes may be one of the causes of the lipid metabolism mechanism disorder in the liver.
Keywords
diabetes mellitus type 2,
insulin resistance,
adiponutrin Gene,
polymorphism,
PNPLA3,
rs738409,
I148M
Supporting agencies: The study was supported by Federal Agency for Scientific Organizations program for support the bioresource collections (0556-2017-0003).
About the Authors
Kh. A. Kurtanov
YSC CMP
Russian Federation
Russian Federation
Kurtanov Khariton Alekseevich - Candidate of Medical Science, Chief Researcher, Head of the Department of Molecular Genetics
Yakutsk, Republic Sakha (Yakutia)
N. I. Pavlova
YSC CMP
Russian Federation
Russian Federation
Pavlova Nadejda Ivanovna – Candidate of Biological Sciences, Leading Researcher, Head of the Laboratory of Hereditary Pathology
Yakutsk, Republic Sakha (Yakutia)
N. P. Filippova
YSC CMP
Russian Federation
Russian Federation
Filippova Natalya Pavlovna – Candidate of Biological Sciences, Senior Researcher of the Laboratory of Hereditary Pathology
Yakutsk, Republic Sakha (Yakutia)
G. A. Apsolikhova
YSC CMP
Russian Federation
Russian Federation
Apsolikhova Galina Aleksandrovna – junior researcher of the laboratory of hereditary pathology
Yakutsk, Republic Sakha (Yakutia)
N. A. Solovieva
YSC CMP
Russian Federation
Russian Federation
Solovieva Natalya Alekseevna – Candidate of Biological Sciences, Leading Researcher, Head of the Laboratory of Population Genetics
Yakutsk, Republic Sakha (Yakutia)
V. V. Dodokhov
YSC CMP
Russian Federation
Russian Federation
Dodokhov Vladimir Vladimirovich – Candidate of Biological Sciences, Senior Researcher of the Laboratory of Hereditary Pathology
Yakutsk, Republic Sakha (Yakutia)
M. A. Varlamova
YSC CMP
Russian Federation
Russian Federation
Varlamova Marina Alekseyevna – researcher of the Laboratory of hereditary pathology
Yakutsk, Republic Sakha (Yakutia)
A. T. Dyakonova
YSC CMP
Russian Federation
Russian Federation
Dyakonova Aleksandra Timofeyevna – researcher of the laboratory of hereditary pathology
Yakutsk, Republic Sakha (Yakutia)
L. M. Neustroyeva
YSC CMP
Russian Federation
Russian Federation
Neustroyeva Lena Mikhaylovna – researcher of the Laboratory of Population Genetic
Yakutsk, Republic Sakha (Yakutia)
N. V. Borisova
North-Eastern Federal University, Medical Institute
Russian Federation
Russian Federation
Natalya Vladimirovna Borisova - doctor of Medical Sciences, Professor of the Department «Normal and Pathological Physiology»
Yakutsk, Republic Sakha (Yakutia)
L. A. Sydykova
North-Eastern Federal University, Medical Institute
Russian Federation
Russian Federation
Sydykova Lyubovy Akhmedovna - Candidate of Medical Science, Head of Department of propaedeutic and faculty therapy with endocrinology and physical therapy
Yakutsk, Republic Sakha (Yakutia)
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For citations:
Kurtanov Kh.A., Pavlova N.I., Filippova N.P., Apsolikhova G.A., Solovieva N.A., Dodokhov V.V., Varlamova M.A., Dyakonova A.T., Neustroyeva L.M., Borisova N.V., Sydykova L.A. Research of adiponutrin gene (PNPLA3) in indigenous people of the Republic Sakha (Yakutia) with type 2 diabetes. Yakut Medical Journal. 2018;(1):11-14. https://doi.org/10.25789/YMJ.2018.61.02
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