Lipid spectrum features and relationship between specific classes of lipids and sex hormone levels in Asian North men
https://doi.org/10.25789/YMJ.2019.67.07
Abstract
A comparative assessment of the main parameters of lipid and sex hormone metabolism in men – the indigenous and non-indigenous residents of the Asian North – and relatively healthy men in Western Siberia was carried out (comparison group). It was found that the lipid profile in indigenous men was characterized by a shift in the spectrum of lipoproteins towards high density lipoprotein cholesterol (HDL cholesterol) compared with the lipid profile in the non-indigenous population and the comparison group. The atherogenicity coefficient (CA) in the indigenous people did not exceed the permissible values. A positive correlation was found between the cholesterol level of low density lipoproteins (LDL cholesterol) and CA with a calendar age, as well as the content of HDL cholesterol with DHEA-S of both indigenous and non-indigenous residents of the Asian North. DHEA-S level in non-indigenous population was found to negatively correlate with triglycerides and atherogenic coefficient. This group of men was characterized by high levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol and high atherogenic coefficient.
Keywords
lipid profile,
sex hormones,
indigenous and non-indigenous residents,
Asian North,
Arctic zone of the Russian Federation
Supporting agencies: The study was carried out with the partial support of the Presidium of the Russian Academy of Sciences under the basic research Program «Exploratory Fundamental studies for the development of Arctic region of the Russian Federation» (FRC FTM) and the project budget № 0324-2019-0041 (FRC ICG SB RAS). We used the equipment of Core Facility “Modern Optical Systems”, Federal Research Center of Fundamental and Translational Medicine (Novosibirsk, Russia).
About the Authors
L. B. Kim
Federal Research Center of Fundamental and Translational Medicine (FRC FTM)
Russian Federation
Russian Federation
Kim Lena Borisovna – Doctor of Medical Sciences, chief researcher, Head of Group of Connective Tissue Biochemistry
+7(383)334-82-11, 2 ul. Timakova, 630117, Novosibirsk
L. P. Osipova
Institute of Cytology and Genetics SB RAS;
Novosibirsk State University
Russian Federation
Russian Federation
Osipova Lyudmila Pavlovna – Candidate of Biological Sciences, 1 Head of Laboratory of Population Ethnogenetics
10 pr. akad. Lavrent'eva, Novosibirsk
2 ul. Pirogova, Novosibirsk, Akademgorodok
A. A. Rozumenko
Federal Research Center of Fundamental and Translational Medicine (FRC FTM)
Russian Federation
Russian Federation
Rozumenko Aleksandr Anatol'evich – Candidate of Biological Sciences, senior researcher of Laboratory of Medical Biotechnology
2 ul. Timakova, 630117, Novosibirsk
A. N. Putyatina
Federal Research Center of Fundamental and Translational Medicine (FRC FTM)
Russian Federation
Russian Federation
Putyatina Anna Nikolaevna – Candidate of Medical Sciences, researcher in Group of Connective Tissue Biochemistry
2 ul. Timakova, 630117, Novosibirsk
G. S. Russkikh
Federal Research Center of Fundamental and Translational Medicine (FRC FTM)
Russian Federation
Russian Federation
Russkikh Galina Sergeevna – Candidate of Biological Sciences, senior researcher of Laboratory of Medical Biotechnology
2 ul. Timakova, 630117, Novosibirsk
T. V. Kozaruk
Federal Research Center of Fundamental and Translational Medicine (FRC FTM)
Russian Federation
Russian Federation
Kozaruk Tat'yana Vladimirovna – specialist in clinical laboratory diagnostics, RI ECM
2 ul. Timakova, 630117, Novosibirsk
N. P. Voronina
Federal Research Center of Fundamental and Translational Medicine (FRC FTM)
Russian Federation
Russian Federation
Voronina Natal'ya Petrovna – Doctor of Biological Sciences, senior researcher, specialist in clinical laboratory diagnostics, RI ECM
2 ul. Timakova, 630117, Novosibirsk
References
1. Averyanova I.V. Lipid and carbohydrate metabolism in indigenous and Caucasian young males living in the Magadan Region / I.V. Averyanova, A.L. Maksimov, N.S. Borisenko // Vest. Sev. (Arktich.) feder. un-ta. Ser.: Med.-biol. nauki. – 2016. – № 2. – Р. 5–15.
2. Agbalyan E.V. Current trends in the nature of nutrition and blood lipid spectrum in the indigenous peoples of Far North / E.V. Agbalyan, I.E. Ionova // Prof. zabol. i ukrep. zdorov'ya. – 2005. – № 3. – P. 16–19.
3. Atlas of the sanitary and epidemiological situation in the Arctic zone of the Russian Federation (2017) / Ed. by PhD S.A. Gorbanev. – St. Peterburg, 2017. – 52 р.
4. Gudkov A.B. External breathing of a person in the European North / A.B. Gudkov, O.N. Popova. – Arkhangel'sk: Izd-vo Severnogo Gos. Med. Univ., 2012. – 252 р.
5. Darenskaya M.A. Peculiarities of metabolic reactions in indigenous and migrant populations of the North and Siberia / M.A. Darenskaya // Byul. VSNTs SO RAMN. – 2014. – № 2. – P. 97–103.
6. Kaznacheev V.V. Mechanisms of human adaptation in high latitudes / V.V. Kaznacheev. – Leningrad: Meditsina, 1980. – 200 р.
7. Kim L.B. Oxygen transport in human adaptation to Arctic conditions and cardiorespiratory pathology / L.B. Kim. – Novosibirsk: Nauka, 2015. – 216 p.
8. Kim L. B. Study of molecular marker of ageing in male residents of the European North of Russia / L.B. Kim, P.M. Kozhin, A.N. Putyatina // Zhurn. med.-biol. issledovanij. – 2017. – Vol. 5, № 3. – P. 70–78.
9. The blood lipid profile and the lipid metabolizm disorders in the indegenious people of Yakutia / Т.Е. Uvarova, T.E. Burtseva, S.I. Sofronova [et al.] // Dal'nevost. med. zhurn. – 2012. – № 3. – Р. 85–88.
10. The mechanism of reverse transport of cholesterol and cholelithiasis in northern peoples / V.V. Tsukanov, K.G. Nozdrachev, Yu.L. Tonkikh [et al.] // Klin. medicina. – 2007. – Vol. 85, № 2. – Р. 33–35.
11. Some features of coronary atherosclerosis risk factors in the inhabitants of Yakutia / M.I. Voevoda, A.N. Romanova, Yu.I. Ragino [et al.] // Byulleten' SO RAMN. – 2010. – Vol. 30, № 3. – P. 52–58.
12. Panin L.E. Fundamental problems of the circumpolar and arctic medicine / L.E. Panin // Byulleten' SO RAMN. – 2013. – Vol. 33, № 6. – P. 5–10.
13. Патология человека на Севере / А.П. Авцын, А.А. Жаворонков, А.Г. Марычев [и др.]. – М.: Медицина, 1985. – 415 с.
14. Human pathology in the North / A.P. Avtsyn, А.А. Zhavoronkov, A.G. Marytchev [et al.]. – M.: Meditsina, 1985. – 415 р.
15. Lipid metabolism in the non-indigenous population of Yakutia depending on length of stay in the North / Z.N. Krivoshapkina, G.E. Mironova, E.I. Semenova [et al.] // Jakutskij medicinskij zhurnal. – 2018. – № 2 (62). – P. 28–30.
16. The state of antioxidant protection of the body in patients with coronary heart disease in the North depending on ethnicity / A.I. Yakovleva, E.D. Okhlopkova, Z.N. Krivoshapkina [et al.] // Jakutskij medicinskij zhurnal. – 2018. – № 2 (62). – Р. 38–40.
17. Titov V.N. Very low and low density lipoproteins: function, fatty acid transport and diagnostic value / V.N. Titov // Klin. lab. diagnostika. – 2000. – № 11. – P. 25–32.
18. Physiological features of metabolic activity of lipids, carbohydrates and proteins in inhabitants of southern districts of Archangelsk Region / F.A. Bichkayeva, L.P. Zhilina, E.R. Boyko [et al.] // Ekologiya cheloveka. – 2006. – № 3. – Р. 7–11.
19. Age-related decrease of dehydroepiandrosterone concentrations in low density lipoproteins and its role in the susceptibility of low density lipoproteins to lipid peroxidation / A. Khalil, J.-P. Fortin, J.-G. LeHoux [et al.] // J. Lipid Res. – 2000. – Vol. 41, № 10. – P. 1552–1561.
20. Are low dehydroepiandrosterone sulphate levels predictive for cardiovascular diseases? A review of prospective and retrospective studies / L. Thijs, R. Fagard, F. Forette [et al.] // Acta Cardiol. – 2003. – Vol. 58, № 5. – P. 403–410. DOI: 10.2143/AC.58.5.2005304
21. Barrett-Connor E.D. The epidemiology of DHEAS and cardiovascular disease / E.D. Barrett-Connor, D. Goodman-Gruen // Ann. NY Acad. Sci. – 1995. – Vol. 774, № 1. – P. 259–270. DOI: 10.1111/j.1749-6632.1995.tb17386.x-i1
22. Cardiovascular burden and related risk factors among Nunavik (Quebec) Inuit: Insights from baseline findings in the circumpolar Inuit Health in Transition cohort study / M.-L. Chateau-Degat, E. Dewailly, R. Louchini [et al.] // Can. J. Cardiol. – 2010. – Vol. 26, № 6. – P. 190–196. DOI: 10.1016/s0828-282x(10)70398-6
23. LDL biochemical modifications: a link between atherosclerosis and aging / M. Alique, C. Luna, J. Carracedo [et al.] // Food Nutr. Res. – 2015. – Vol. 59. DOI: 10.3402/fnr.v59.29240
24. No association between dehydroepiandrosterone sulphate and development of atherosclerosis in prospective population study (Bruneck Study). Arterioscler / S. Kiechl, J. Willeit, E. Bonora [et al.] // Thromb. Vasc. Biol. – 2000. – Vol. 20, № 4. – P. 1094–1100.
25. Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23) / R.C. Turner, H. Millns, H.A. Neil [et al.] // BMJ. – 1998. – Vol. 316, № 7134. – P. 823–828. DOI: 10.1136/bmj.316.7134.823
26. Sex hormones and cardiovascular risk in male mining workers living in the European North / L.B. Kim, G.S. Russkikh, M.M. Gevorgian [et al.] // Human Physiology. – 2016. – Vol. 42, № 2. – P. 195–202. DOI: 10.1134/S0362119716020080
Review
For citations:
Kim L.B., Osipova L.P., Rozumenko A.A., Putyatina A.N., Russkikh G.S., Kozaruk T.V., Voronina N.P. Lipid spectrum features and relationship between specific classes of lipids and sex hormone levels in Asian North men. Yakut Medical Journal. 2019;(3):27-31. https://doi.org/10.25789/YMJ.2019.67.07
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