Expression of some molecular and biological markers in different periods of progression after radical surgical treatment of esophageal cancer

Abstract

A retrospective analysis of patients with II and III stages of the disease, diagnosed with squamous cell carcinoma of the esophagus after surgical treatment was performed. The prognostic significance of the expression of immunohistochemical markers p53, bcl-2, ki-67, E-cadherin, as well as the proliferative activity of tumors, was studied. A significant decrease in the frequency of tumors expressing p53, as well as an increase in the number of tumors expressing bcl-2, was detected in the group of patients with an increase in the event-free period for up to 365-540 days. In the group with progression from 181 to 364 and from 365 to 540 days, the average indicator of bcl-2 positive cells in the tumor is 2.3 and 2.8 times higher than in patients with progression up to 180 days. The ki-67 index in the group with progression up to 180 days was significantly higher than that in the group with progression from 181–364 and 365–540 days. High proliferative activity was detected only in patients with progression up to 180 days. The expression of E-cadherin in the group with progression from 365–540 days is significantly higher than that of patients with progression < 180 and 181–364 days.