Correlation of the M235T polymorphism of the AGT gene with arterial hypertension and its risk factors in the indigenous people of the arctic territory of Yakutia
https://doi.org/10.25789/YMJ.2019.67.04
Abstract
A case-control study was conducted for the indigenous population living in the Arctic territory of Yakutia to determine the association of the M235T polymorphism of the AGT gene with hypertension and its risk factors. A higher average blood pressure, elevated cholesterol and its fractions, a higher incidence of abdominal obesity in carriers of the mutant GG genotype were found both in the general population and separately for people with hypertension. The study shows the contribution of the G allele of the AGT gene to the development of hypertension, lipid disorders and abdominal obesity.
Supporting agencies: The research was conducted within research projects of YSC CMP "A contribution of a metabolic syndrome to development of atherosclerosis of coronary arteries in residents of Yakutia", R&D "De velopment of new technologies of treatment and risk prediction of hypertension and insult in the Republic of Sakha (Yakutia)" (Government contract No. 1133).
About the Authors
S. I. Sofronova
Yakut science centre of complex medical problems
Russian Federation
Russian Federation
Sofronova Sargylana Ivanovna – PhD, Head of Scientific-organizational and information publishing Department
677000, Sergelyakhskoe shosse, 4, Yakutsk, The Republic of Sakha (Yakutia)
A. N. Romanova
Yakut science centre of complex medical problems
Russian Federation
Russian Federation
Romanova Anna Nikolaevna – MD, Director
677000, Sergelyakhskoe shosse, 4, Yakutsk, The Republic of Sakha (Yakutia)
M. P. Kirillina
Yakut science centre of complex medical problems
Russian Federation
Russian Federation
Kirillina Maria Petrovna – PhD (Biology), leading researcher, head of lab.
677000, Sergelyakhskoe shosse, 4, Yakutsk, The Republic of Sakha (Yakutia)
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Review
For citations:
Sofronova S.I., Romanova A.N., Kirillina M.P. Correlation of the M235T polymorphism of the AGT gene with arterial hypertension and its risk factors in the indigenous people of the arctic territory of Yakutia. Yakut Medical Journal. 2019;(3):16-19. https://doi.org/10.25789/YMJ.2019.67.04
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