Determination of HLA alleles using single nucleotide polymorphism of rs3104413 HLA-DQA1 gene among patients with type 1 diabetes of the RS (Ya)
https://doi.org/10.25789/YMJ.2019.67.03
Abstract
In this work, we analyzed the polymorphism rs3104413 of the HLA-DQA1 gene among patients with type 1 diabetes and a control sample from the Sakha Republic (Yakutia). Diabetes mellitus type 1 (type 1 diabetes) among all forms of diabetes is no more than 10-15%, and type 1 diabetes is considered to be the most important medico-social problem of health care, since this disease often occurs in childhood and adolescence, it is characterized by the severity of the course, early disability and mortality.
Supporting agencies: The study was conducted in the framework of research on the study of the genetic structure and burden of hereditary pathology of populations of the Republic of Sakha (Yakutia).
About the Authors
A. T. D'yakonova
YSC CMP
Russian Federation
Russian Federation
D'yakonova Aleksandra Timofeevna – Junior researcher of the laboratory of heritable pathology
Tel.: 8 (914) 238 68 93
Yakutsk, Republic Sakha (Yakutia)
Kh. A. Kurtanov
YSC CMP
Russian Federation
Russian Federation
Kurtanov Khariton Alekseevich – Candidate of Sciences., Chief Scientific Officer - Head of the Department of Molecular Genetics
Tel.: +7 (914) 106 00 30
Yakutsk, Republic Sakha (Yakutia)
N. I. Pavlova
YSC CMP
Russian Federation
Russian Federation
Pavlova Nadezhda Ivanovna – Candidate of Sciences, chief scientific officer - head of the laboratory of heritable pathology
Tel.: +7 (914) 289 39 36
Yakutsk, Republic Sakha (Yakutia)
N. A. Solov'eva
YSC CMP
Russian Federation
Russian Federation
Solov'eva Natal'ya Alekseevna – Candidate of Sciences, - researcher of the Laboratory of Population Genetics
Tel.: 8 (924) 171 34 89
Yakutsk, Republic Sakha (Yakutia)
N. P. Filippova
YSC CMP
Russian Federation
Russian Federation
Filippova Natal'ya Pavlovna – Candidate of Sciences, associate professor, researcher of the Laboratory of Population Genetics
Tel.: 8 (914) 303 43 95
Yakutsk, Republic Sakha (Yakutia)
T. N. Аleksandrova
YSC CMP
Russian Federation
Russian Federation
Аleksandrova Tujara Nikonovna - Junior researcher of the laboratory of heritable pathology
Yakutsk, Republic Sakha (Yakutia)
References
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Review
For citations:
D'yakonova A.T., Kurtanov Kh.A., Pavlova N.I., Solov'eva N.A., Filippova N.P., Аleksandrova T.N. Determination of HLA alleles using single nucleotide polymorphism of rs3104413 HLA-DQA1 gene among patients with type 1 diabetes of the RS (Ya). Yakut Medical Journal. 2019;(3):13-15. https://doi.org/10.25789/YMJ.2019.67.03
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