Role of polymorphism of I148M gene PNPLA3 in the progression of liver diseases in patients with chronic viral hepatitis B, C
Abstract
The article presents an overview of the results of research by a number of authors concerning the relationship between I148M polymorphism of gene PNPLA3 variant and steatosis, fibrosis, liver cancer in patients with chronic hepatitis B and C.
About the Authors
S. S. Sleptsova
North-Eastern Federal University named after M.K. Ammosov
Russian Federation
Russian Federation
Yakutsk
A. E. Efimov
North-Eastern Federal University named after M.K. Ammosov
Russian Federation
Russian Federation
Yakutsk
Kh. A. Kurtanov
Yakut Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Yakutsk
References
1. Abdurakhmanov D.T. Steatosis of the liver in chronic hepatitis C: mechanisms of development and role in the progression of liver damage / D.T. Abdurakhmanov // Clinical hepatology. – 2005. – № 1. – P. 25-28.
2. The effect of liver steatosis on the effectiveness of combined antiviral therapy of chronic hepatitis C / A.V. Tselikovsky [et al.] // Modern problems of science and education. – 2012. – № 6. – URL: http://science-education.ru/en/article/view?id=7387 (reference date: April 19, 2017).
3. Zhdanov K.V. Viral hepatitis / K.V. Zhdanov, Yu.V. Lobzin, D.A. Gusev, K.V. Kozlov. – SPb.: Folio, 2011. – 304 p.
4. Sleptsova S,S. The role of viral hepatitis in the development of primary liver cancer in Yakutia / SS. Sleptsova, A.G. Rakhmanova, V.V. Sharoiko // Infectious diseases. – 2015. – № 3. – P. 76-82.
5. Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase / M. Kumari [et al.] // Cell Metab. – 2012. – Vol. 12. – № 5. – P. 691–702.
6. Aghemo A. Understanding the role of PNPLA3 genetic vari¬ants in patients with chronic hepatitis C infection // Dig Dis Sci. – 2012. – Vol. 57. – № 8. – P. 1977–1979.
7. Akamatsu N. Liver transplantation and hepatitis C [Электронный ресурс] / N. Akamatsu, Y. Sugawara // Int J Hepatol. – 2012. – Vol. 2012. – doi: 10.1155/2012/686135 (reference date: 24. 04. 2017).
8. Association between PNPLA3 rs738409 polymorphism and hepatocellular carcinoma risk: an updated meta-analysis / L. Zhang [et al.] // Genes & Genomics. – 2016. – Vol. 38. – № 9. – P. 831–839.
9. Association of nonalcoholic fatty liver disease with insulin resistance / G. Marchesini [et al.] // Am. J. Med. – 1999. – Vol. 107. – P. 450–455.
10. Association of PNPLA3 I148M Variant With Chronic Viral Hepatitis, Autoimmune Liver Diseases and Outcomes of Liver Transplantation [Electronic resource] / N. Geng [et al.] // Hepatitis Monthly. – 2015. – Vol. 15. – № 4. – URL: http://hepatmon.com/?page=article&article_id=26459 (дата обращения: 21. 01. 2017).
11. Brunt E.M. Nonalcoholic steatohepatitis: definition and pathology / Brunt E.M. // Semin. Liver Dis. – 2001. – Vol. 21. – P. 3–16.
12. Correlation between patatin-like phospholipase domain-containing protein 3 gene polymorphisms and liver cirrhosis in a chinese han population with chronic hepatitis B [Электронный ресурс] / J. Tong [et al.] // Hepat Mon. – 2014. – Vol. 14. – №8. – URL: http://hepatmon.com/?page=article&article_id=18943 (reference date: 08. 04. 2017).
13. Donor PNPLA3 rs738409 genotype affects fibrosis progression in liver transplantation for hepatitis C / W. Dunn [et al.] // Hepatology. – 2014. – Vol. 59. – № 2. – P. 453-460.
14. Genetic polymorphisms of IL28B and PNPLA3 are predictive for HCV related rapid fibrosis progression and identify patients who require urgent antiviral treatment with new regimens / N. Tamaki [et al.] // PLoS ONE. – 2015. – Vol. 10. – № 9. – P. 1–12.
15. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease / S. Romeo [et al.] // Nat. Genet. – 2008. – Vol. 40. – P. 1461–1465.
16. Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease / P. Dongiovanni [et al.] // Gut. – 2010. – № 59. – Р. 267–73.
17. Hepatic steatosis and insulin resistance are associated with severe fibrosis in patients with chronic hepatitis caused by HBV or HCV infection / S. Petta [et al.] // Liver Int. – 2011. – Vol. 31. – № 4. – P. 507-515.
18. Mackawy A. M. H. Patatin-like phospholipase domain containing-3 gene (PNPLA3) I148M polymorphism and liver damage in chronic hepatitis C Egyptian patients / A. M. H. Mackawy, M. E. H. Badawi, O. Megahed // Egyptian Journal of Medical Human Genetics. – 2015. – Vol. 16. – № 4. – P. 333-441.
19. Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C / L. Valenti [et al.] // Hepatology. – 2011. – Vol. 53. – № 3. – P. 791–799.
20. Patatin-Like Phospholipase Domain-Containing 3 I148M Variant Is Associated with Liver Steatosis and Fat Distribution in Chronic Hepatitis B / R. Zampino [et al.] // Digestive Diseases and Sciences. – 2015. – Vol. 60. – № 10. – P. 3005–3010.
21. Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro / C. Pirazzi [et al.] // J. Hepatol. – 2012. – Vol. 57. – № 6. – P. 1276-1282.
22. Patatin-like phospholipase domaincontaining protein 3 rs738409-G in recipients of liver transplants is a risk factor for graft steatosis / A. Finkenstedt [et al.] // Clin Gastroenterol Hepatol. – 2013. – Vol. 11. – № 12. – P. 1667–1672.
23. PNPLA 3 I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection / K. Rembeck [et al.] // BMC Med Genet. – 2012. – Vol. 13. – № 1. – P. 1.
24. PNPLA3 I148M polymorphism and progressive liver disease / P. Dongiovanni [et al.] // World Journal of Gastroenterology. – 2013. – Vol. 19. – № 41. – P. 6969-6978.
25. PNPLA3 I148M Polymorphism, Clinical Presentation, and Survival in Patients with Hepatocellular Carcinoma [Электронный ресурс] / L. Valenti [et al.] // PLoS ONE. – 2013. – Vol. 8. – № 10. – URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075982 (reference date: 22. 01. 2017).
26. PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis. / J.-H Fan [et al.] // Gut and Liver. – 2016. – Vol. 10. – № 3. – P. 456–63.
27. Rembeck K. Impact of IL28B, ITPA and PNPLA3 genetic variants on therapeutic outcome and progression of hepatitis C virus infection / K. Rembeck, M. Lagging // Pharmacogenomics. – 2015. – Vol. 16. – № 10. – P. 1179-1188.
28. Significant Association Between Adiponutrin and Hepatocellular Carcinoma Risk [Электронный ресурс] / H.-G. Li [et al.] // Medicine. – 2015. – Vol. 94. – № 45. – URL: http://journals.lww.com/md-journal/page/results.aspx?txtkeywords=e2019 (reference date: 08. 04. 2017).
29. Yoon E.J. Hepatitis C virus (HCV) infection and hepatic steatosis / E.J. Yoon, Hu. Ke-Qin // Int. J. Med. Sci. – 2006. – Vol. 3. – № 3. – P. 53–56.
Review
For citations:
Sleptsova S.S., Efimov A.E., Kurtanov Kh.A. Role of polymorphism of I148M gene PNPLA3 in the progression of liver diseases in patients with chronic viral hepatitis B, C. Yakut Medical Journal. 2017;(2):38-40.
Views:
29
Email this article 