Changes of cytokine production in children affected with acute respiratory viral infections at polymorphism of TOLL-4 (Asp299Gly) and TOLL-6 (SER249Pro) genes receptors
Abstract
The article analyzes the role of polymorphism of Toll-4 (Asp299Gly) and Toll-6 (Ser249Pro) receptor genes in the development of low antiviral protection in children with frequent episodes of acute respiratory infections. It is shown that the synthesis of cytokines IL-1-β, TNF-α decrease in the blood of patients with Toll-4 receptor gene polymorphism and IL-1RA content is increased in comparison with the group of diseased children without abnormal disturbances in signal receptors. Polymorphism in the Toll-6 receptor genes decreases the concentration of cytokines IL-1β, IL-8, TNF-α and IL-10. The concentration of IL-1RA is increased in Pro / Pro and Gly / Gly genotypes compared to the group of patients without polymorphic changes in the corresponding receptors. Genetic disorders in the synthesis of cytokines in the polymorphism of the Toll-4 (Asp299Gly) and Toll-6 (Ser249Pro) receptors are one of the reasons for the failure of antiviral protection in children who often have ARI.
About the Authors
L. P, Malyzhik
Chita State Medical Academy
Russian Federation
Russian Federation
Chita
M. S. Malezhik
Chita State Medical Academy
Russian Federation
Russian Federation
Chita
D. C. Nimaeva
Chita State Medical Academy
Russian Federation
Russian Federation
Chita
V. B. Tsyrendorzhieva
Chita State Medical Academy
Russian Federation
Russian Federation
Chita
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Review
For citations:
Malyzhik L.P., Malezhik M.S., Nimaeva D.C., Tsyrendorzhieva V.B. Changes of cytokine production in children affected with acute respiratory viral infections at polymorphism of TOLL-4 (Asp299Gly) and TOLL-6 (SER249Pro) genes receptors. Yakut Medical Journal. 2017;(2):11-13.
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