Probable causes of Vilyui encephalomyelitis. Facts of the study history and reasoning
https://doi.org/10.25789/YMJ.2019.65.35
Abstract
Vilyui encephalomyelitis (VEM) is a degenerative disease of the central nervous system, in the acute form manifested by meningoencephalitis that tends to develop into a prolonged chronically progressive panencephalitis, finally leading to death. Despite 60 years of experience in the study of Vilyui encephalomyelitis, the cause of the disease has not been clarified to date. Since 2010 on the territory of Yakutia, no new cases of VEM with classical clinical manifestations have been registered. We have developed a new hypothesis about anthropozoonosis nature of the disease based on the analysis of a sudden stop incidence of VEM. The purpose of this paper is to provide a scientific basis for this hypothesis. We have analyzed the extensive data of clinical observations of patients according to archival data stored in the former NEFU Scientific-Research Institute of Health, as well as a review of scientific publications on VEM over the past 30 years.
Keywords
Vilyui encephalomyelitis,
infectious hypothesis,
anthropozoonosis,
epizooty,
Theiler-like virus,
encephalitis viruses
Supporting agencies: This work was prepared in the framework of the state assignment 17.6.3442017 / BP «Clinical and genetic aspects of diseases characteristic of the indigenous inhabitants of Yakutia in modern conditions.”
About the Authors
D. G. Tikhonov
medical Institute of the North-Eastern Federal University
Russian Federation
Russian Federation
Tikhonov Dmitry Gavrilovich, MD, Professor, Senior Research Officer of the Scientific research Center
phone +79241735340
Yakutsk, Republic Sakha (Yakutia)
V. A. Vladimirtsev
medical Institute of the North-Eastern Federal University
Russian Federation
Russian Federation
Vladimirtsev Vsevolod Afanasievich, PhD, Senior Research Officer of the Scientific research Center
phone +79142312599
Yakutsk, Republic Sakha (Yakutia)
V. P. Nikolaev
Yakut scientific center of complex medical problems
Russian Federation
Russian Federation
Nikolaev Valerian Parfenyevich, PhD
Yakutsk
E. G. Shadrina
Institute of Biology of permafrost zone, YSC of Siberian Branch of RAS
Russian Federation
Russian Federation
Shadrina Elena Georgievna, Doctor of Biological Sciences, Professor
Yakutsk
References
1. Bolo S.I. The Yakut past before the arrival of the Russian to the Lena River: according to the legends of the Yakut of the former Yakut district / S.I. Bolo. – Yakutsk: National Publishing house «Bichik», 1994. – 352 p.
2. Goldfarb L. G. Vilyui encephalomyelitis / L.G. Goldfarb, V.A. Vladimirtsev, N.M. Renwick, F. A. Platonov. – Novosibirsk: Publishing house SB RAS, 2014. – 256 p.
3. Karavanov A. S. Explantation of the combined materials of the human brain biopsy and autopsy to isolate viral agents in Viliuisk encephalomyelitis / A.S. Karavanov, V.A. Zaklinskaya, E.C. Sarmanova, M.P. Gogolev // Issues of medical virology: reports of the XVIII scientific session of the Institute of poliomyelitis and viral encephalitis AMS USSR. – M., 1975. – P. 377-378.
4. Osakovsky V.L. Immunopathology of Vilyui encephalomyelitis / V.L. Osakovsky, T.M. Sivtseva, V.G. Krivoshapkin // Neuroimmunology. – 2012. – Vol. 10, № 3-4. – P. 22-27.
5. The characteristics of cytokine status and intrathecal synthesis of oligoclonal IgG in patients with Vilyui encephalomyelitis and multiple sclerosis / T.M. Sivtseva, R.I. Chemezova, V.A. Vladimirtsev [et al.] // Yakut med. journal. – 2011. – № 4 (36). – P. 27-30.
6. Another attempt to test the hypothesis of viral etiology of Vilyui encephalitis / G.G. Karganova, M.V. Bardina, A.P. Gmyl [et al.] // Mater. of the Interregional scientific research.– pract. conf. – 2011.
7. Petrov P. A. Vilyui encephalitis / P. A. Petrov. – Novosibirsk: Science, 1987. – 134 p.
8. Sarmanova E.S. A study of the etiology of Vilyui encephalomyelitis. Message 1. Study of biological features of virus strains isolated from sick people / E.S. Sarmanova, G.G. Chumachenko // Issues of medical virology. – M., 1960. – P. 211-214.
9. Tikhonov D.G. Arctic medicine / D.G. Tikhonov. – Yakutsk: Publ. YSC SB RAS, 2010. – 317 p.
10. Long-clawed ground squirrel, Loir, mole-rat chipmunk / S.I. Naumov, N.V. Lavrov, E.P. Spangenberg [et al.]. – M. – L.: All-Union cooperative united publishing house, 1935. – 104 p.
11. Fedorova N.I. Epidemiological significance of migrants in the prevalence of Vilyui encephalomyelitis / N.I. Fedorova, L.G. Goldfarb // Vilyui encephalomyelitis in Yakutia. – M.: AMS of the USSR. – 1979. Deposited manuscript.
12. Donald G., Feltz R., Feltz T. on the natural occurrence of California encephalitis virus and other arboviruses in Alaska. Can. J. Microbial. 20: 1359-1366.
13. Drappier M, Opperdoes FR, Michiels T. Nonstructural Protein L* Species Specificity Supports a Mouse Origin for Vilyuisk Human Encephalitis Virus. J Virol. 2017 Jun 26;91 (14). pii: e00573-17. doi: 10.1128/JVI.00573-17.
14. Green AJ, Sivtseva TM, Danilova AP, Osakovsky VL, Vladimirtsev VA, Zeidler M, Knight RS, Platonov FA, Shatunov a, Alekseev VP, Krivoshapkin VG, Masters CL, Gajdusek DC, Goldfarb LG. Vilyuisk encephalomyelitis: intrathecal synthesis of oligoclonal IgG. J Neurol Sci. 2003 Aug 15; 212 (1-2):69-73.
15. Hoffmann B, Tappe D, Höper D, Herden C, Boldt A, Mawrin Ch, Niederstraße O, Müller T, Jenckel M, van der Grinten E, Lutter Ch, Abendroth B, Teifke J, Cadar D, Schmidt-Chanasit J, M. D., Ulrich R. G, Beer M. A Varied Squirrel Bornavirus Associated with Fatal Human encephalitis. N Engl J Med 2015; 373: 154-62. DOI: 10.1056/NEJMoa1415627.
16. Siberia’s deadly stalker emergencies from the shadows. Science. 2002 Apr 26; 296(5568):642-5. Doi: 10.1126/science.296.5568.642.
17. Lee HS, Zhdanova SN, Vladimirtsev VA, Platonov FA, Osakovskiy VL, Subbotina EL, Broytman O, Danilova AP, Nikitina RS, Chepurnov AA, Krivoshapkin VG, Gajdusek DC, Savilov YD, Garruto RM, Goldfarb LG. Epidemiology of Viliuisk encephalomyelitis in Eastern Siberia. Epidemiology. 2010 Jan; 21 (1):24-30. doi: 10.1097/EDE.0b013e3181c30fd2.
18. Lvov D. K., Shchelkanov, M. Y., Alkovsky S. V., Deryabin P. G. Zoonotic viruses of Northern Eurasia. Taxonomy and Ecology/ London: Elsevier Inc. 2017. – 438 p.
19. Oleszak E.L., Chang J.R,. Friedman H, Katsetos CD, Platsoucas CD. Theiler’s virus infection: a model for multiple sclerosis. Clin Microbiol Rev. 2004 Jan; 17 (1):174-207.
20. Oleksyk T.K., Goldfarb L.G., Sivtseva T., Danilova AP, Osakovsky VL, Shrestha S, O’brien SJ, Smith MW. Evaluating association and transmission of eight inflammatory genes with Viliuisk encephalomyelitis susceptibility. Eur J Immunogenet. 2004 Jun; 31 (3):121-8.
21. Walters L.L., Tirrell S.J., Shope R.E. Seroepidemiology of California and Bunyamwera serogroup (Bunyaviridae) virus infections in native populations of Alaska. The American Journal of Tropical Medicine and Hygiene, Volume 60, Issue 5, May 1999, p. 11. 806-821. Doi: 10.4269/ajtmh.1999.60.806.
22. Stone R. Infectious disease. Siberia’s deadly stalker emergencies from the shadows. Science. 2002 Apr 26; 296(5568):642-5. Doi: 10.1126 / science.296.5568.642.
Review
For citations:
Tikhonov D.G., Vladimirtsev V.A., Nikolaev V.P., Shadrina E.G. Probable causes of Vilyui encephalomyelitis. Facts of the study history and reasoning. Yakut Medical Journal. 2019;(1):115-118. https://doi.org/10.25789/YMJ.2019.65.35
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