The influence of the vascular polypeptide complex on the viability of rats under cold stress
https://doi.org/10.25789/YMJ.2022.78.12
Abstract
The influence of polypeptide vessel complex (PVC) for stimulating the respiratory and cardiovascular systems in a model of experimental hypothermia has been studied. The obtained results indicate that after PVC application the heart rate of rats during cooling was significantly higher and the respiratory rate gets lower as compared with the control. The temperature threshold for respiratory failure after PVC was reduced, and the cooling time of rats to respiratory arrest increased twice as compared with the control. It is concluded that PVC slows down the process of cold respiratory depression and cardiac activity.
About the Authors
N. K. Arokina
Pavlov Institute of Physiology, Russian Academy of Sciences
Russian Federation
Russian Federation
Arokina Nadezhda Konstantinovna – Doctor of biological sciences, senior researcher
V. Kh. Khavinson
Saint Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology, Russian Academy of Sciences
Russian Federation
Russian Federation
Khavinson Vladimir Khatskelevich – corresponding member of Russian Academy of Science, honored worker of science, Doctor of medical sciences, Professor, head, head of the group of peptide regulation of aging
N. I. Chalisova
Pavlov Institute of Physiology of RAS
Russian Federation
Russian Federation
Chalisova Natalia Iosifovna – Doctor of biological sciences, professor, leading researcher
N. S. Linkova
Saint Petersburg Institute of Bioregulation and Gerontology; Belgorod National Research University
Russian Federation
Russian Federation
Linkova Natalia Sergeevna – Doctor of biological sciences, docent, head of the laboratory of molecular mechanisms of aging; senior scientific researcher of the laboratory ‘Problems of Aging’, senior researcher of the Laboratory “Problem of Aging”
G. A. Ryzhak
Saint Petersburg Institute of Bioregulation and Gerontology
Russian Federation
Russian Federation
Ryzhak Galina Anatolievna – MD, Doctor of medical sciences, Professor, associate of director on the scientific research and new technologes
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Review
For citations:
Arokina N.K., Khavinson V.Kh., Chalisova N.I., Linkova N.S., Ryzhak G.A. The influence of the vascular polypeptide complex on the viability of rats under cold stress. Yakut Medical Journal. 2022;(2):47-49. https://doi.org/10.25789/YMJ.2022.78.12
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