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Stomach cancer and pregnancy

https://doi.org/10.25789/YMJ.2025.90.34

Abstract

Stomach cancer during pregnancy is extremely rare and accounts for 0.025-0.1% of all pregnancies, while most cases of stomach cancer associated with pregnancy are diagnosed by specialists at a late stage, since its main symptoms (vomiting, nausea, loss of appetite, increased abdominal size) are mistaken for early toxicosis during pregnancy and the likelihood of the development of malignant neoplasms is underestimated. Optimal management of this category of patients requires a multidisciplinary approach (including oncologist, obstetrician, surgeon, anesthesiologist, gastroenterologist, radiologist and neonatologist), which establishes the sequence of therapy. In the article, we presented our own experience of treating and monitoring this category of patients in the form of two clinical cases that clearly demonstrate an extremely unfavorable prognosis for a combination of stomach cancer and pregnancy. According to the literature, the five-year survival rate in this category of patients is zero, while in most cases the patient's death occurs within six months after surgery.

About the Authors

A. L. Chernyshova
ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России; ФГБУ «НМИЦ им. акад. Е.Н. Мешалкина» Минздрава России
Russian Federation


A. A. Chernyakov
Томский НИМЦ РАН
Russian Federation


Y. M. Trusсhuk
Томский НИМЦ РАН
Russian Federation


O. S. Dil
ФГБУ «НМИЦ им. акад. Е.Н. Мешалкина» Минздрава России
Russian Federation


References

1. Qureshi WA, Rajan E, Adler DG, et al. American Society for Gastrointestinal Endoscopy. ASGE Guideline: Guidelines for endoscopy in pregnant and lactating women. Gastrointest Endosc. 2005 Mar;61(3): 357-362. doi: 10.1016/s0016-5107(04)02780-4.

2. Miyamoto S, Yamada M, Kasai Y. Anticancer drugs during pregnancy. Jpn J Clin Oncol.2016 Sep; 46,(9): 795-804. doi: 10.1093/jjco/hyw073.

3. Karowicz-Bilinska A. Carcinoid in appendix in pregnancy. Ginekol Pol. 2022; 93(12): 1028–1029. doi: 10.5603/GP.a2021.0252.

4. Cift T, Aydogan B, Akba M, et al. Case report: gastric carcinoma diagnosed at the second trimester of pregnancy. Case Rep Obstet Gynecol. 2011; 2011: 532854. doi: 10.1155/2011/532854.

5. Pedersen BW, Storgaard L, Clausen MB, et al. Cancer under graviditeten [Cancer in pregnancy]. Ugeskr Laeger. 2015 Jun 29;177(27).

6. Yaghoobi M, Koren G, Nulman I. Challenges to diagnosing colorectal cancer during pregnancy. Can Fam Physician. 2009 Sep: 55(9): 881-885.

7. Nishie H, Mizushima T, Suzuki Y, et al. Chemotherapy treatment of a pregnant woman with progressive gastric cancer. Intern Med. 2015; 54(10): 1207-1212. doi: 10.2169/internalmedicine.54.3973.

8. Rogers JE, Woodard TL, Gonzalez GM, et al. Colorectal cancer during pregnancy or postpartum: Case series and literature review. Obstet Med. 2022 Jun; 15(2): 118–124. doi: 10.1177/1753495X211041228.

9. Marbun VMG, Putranto AS. Diagnosis and management of gastric cancer in pregnancy – an evidence-based case report. Int J Surg Case Rep. 2020; 75: 338-344. doi: 10.1016/j.ijscr.2020.09.109.

10. Bozkurt M, Antonoff M, Jaramillo S, et al. Gastroesophageal Cancer During Pregnancy: a Case Report and Review of the Literature. J Gastrointest Cancer. 2019 Sep; 50(3): 634640. doi: 10.1007/s12029-018-0093-4.

11. Gomes CF, Sousa M, Lourenço I, et al. Gastrointestinal diseases during pregnancy: what does the gastroenterologist need to know? Ann Gastroenterol. 2018 Jul-Aug; 31(4): 385-394. doi: 10.20524/aog.2018.0264.

12. Maggen C, Lok CA, Cardonick E, et al. International Network on Cancer, Infertility and Pregnancy (INCIP). Gastric cancer during pregnancy: A report on 13 cases and review of the literature with focus on chemotherapy during pregnancy. Acta Obstet Gynecol Scand. 2020 an; 99(1): 79-88. doi: 10.1111/aogs.13731.

13. Story L, Rafique S, Samadi N, et al. Lower gastrointestinal bleeding in pregnancy: Differential diagnosis, assessment and management. Obstet Med. 2021 Sep; 14(3): 129-134. doi: 10.1177/1753495X20948300.

14. Silverstein J, Post AL, Chien AJ. Multidisciplinary Management of Cancer During Pregnancy. JCO Oncol Pract. 2020 Sep; 16(9): 545-557. doi: 10.1200/OP.20.00077.

15. Lagiou P, Tamimi R, Mucci LA, et al. Nausea and vomiting in pregnancy in relation to prolactin, estrogens, and progesterone: a prospective study. Obstet Gynecol. 2003 Apr; 101(4): 639-644. doi: 10.1016/s0029-7844(02)02730-8.

16. Constantin A, Constantin R, Achim F, et al. Pregnancy and Gastric Cancer: A Narrative Review. Diagnostics (Basel). 2023. 29;13(11): 1909. doi: 10.3390/diagnostics13111909.

17. Abdel-Rahman O, Ghosh S. Pregnancy and perinatal outcomes following exposure to antineoplastic agents around pregnancy within the US FDA Adverse Event Reporting System. Future Oncol. 2022 Jul; 18(21): 2635-2642. doi: 10.2217/fon-2021-1255.

18. Predescu D, Boeriu M, Constantin A, et al. Pregnancy and Colorectal Cancer, from Diagnosis to Therapeutical Management: Short Review. Chirurgia (Bucur). 2020 Sept-Oct; 115(5): 563-578. doi: 10.21614/chirurgia.115.5.563.

19. Song MJ, Park YS, Song HJ, et al. Prognosis of Pregnancy-Associated Gastric Cancer: An Age-, Sex-, and Stage-Matched Case-Control Study. Gut Liver. 2016 Sep 15; 10(5): 731-738. doi: 10.5009/gnl15323.

20. Kim J, Sun CL, Mailey B, [et al. Race and ethnicity correlate with survival in patients with gastric adenocarcinoma. Ann Oncol. 2010 Jan; 21(1): 152-160. doi: 10.1093/annonc/mdp290.

21. Ismail S.K., Kenny L. Review on hyperemesis gravidarum. Best Pract Res Clin Gastroenterol. 2007; 21(5): 755-769. doi: 10.1016/j.bpg.2007.05.008. PMID: 17889806.

22. , Fell DB, Dodds L, Joseph KS, et al. Risk factors for hyperemesis gravidarum requiring hospital admission during pregnancy. Obstet Gynecol. 2006 Feb; 107(2 Pt1): 277-84. doi: 10.1097/01.AOG.0000195059.82029.74.

23. Akimoto N, Ugai T, Zhong R, et al. Rising incidence of early-onset colorectal cancer – a call to action. Nat Rev Clin Oncol. 2021 Apr; 18(4): 230-243. doi: 10.1038/s41571-020-00445-1

24. Cardonick E, Iacobucci A. Use of chemotherapy during human pregnancy. Lancet Oncol. 2004 May; 5(5): 283–291. doi: 10.1016/S1470-2045(04)01466-4


Review

For citations:


Chernyshova A.L., Chernyakov A.A., Trusсhuk Y.M., Dil O.S. Stomach cancer and pregnancy. Yakut Medical Journal. 2025;(2):158-163. https://doi.org/10.25789/YMJ.2025.90.34

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ISSN 1813-1905 (Print)
ISSN 2312-1017 (Online)