Difficulties in diagnosing multisystem atrophy at early stages (clinical observations)
https://doi.org/10.25789/YMJ.2020.72.29
Abstract
In the article the literature data on MSA, the clinical features are studied and modern diagnostic criteria for this disease are provided.
We introduce our own observations of the patients with various forms of MSA who underwent inpatient treatment at the Center for Neurodegenerative Diseases of the Yakutsk Scientific Center for Complex Medical Problems in 2019-2020.
These clinical cases have been studied with the aim to draw attention of general practitioners and neurologists to the disease onset among elderly patients and to the syndrome of autonomic insufficiency, which may be the initial manifestation of MSA, since this rare disease has a rapidly progressive course and leads to mortaltiy. In turn, the early diagnosis of the disease contributes to timely correction of autonomic and motor disorders and ultimately increases quality and lifetime.
About the Authors
A. E. Adamova
Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Adamova Alina E. – Junior Researcher, Neurologist, Center for Neurodegenerative Diseases
Yakutsk
A. A. Tappakhov
Medical Institute (North-Eastern Federal University);
Мedical Clinic of NEFU;
Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Tappakhov Alexey A. – Candidate of Sciences in Medicine, Associate Professor at the Department of Neurology and Psychiatry;
a neurologist of Neuropsychophysiological Researches;
Senior Researcher, Center for Neurodegenerative Diseases
Yakutsk
T. K. Davydova
Center for Neurodegenerative Diseases of the Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Davydova Tatyana K. – PhD in Medical Sciences, Leading Researcher, Neurologist, Head
Yakutsk
T. E. Popova
Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Popova Tatyana E. – Grand PhD in Medical Sciences, deputy Director for Science
Yakutsk
Yu. I. Khabarova
Center for Neurodegenerative Diseases of the Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Khabarova Yulia I. – Junior Researcher, Head
Yakutsk
References
1. Valikova T.A. Multisystem atrophy: clinical manifestations, pathogenesis questions / T.A. Valikova, N.V. Pugachenko, Ye.S Korolyeva // Scientific and educational process: methodological seminar. – 2010. – Vol. 4. – P. 100-106 (in Russ).
2. Differential diagnosis of multisystem atrophy and essential tremor with Parkinson's disease (clinical cases) / A.A. Tappakhov, T.Ya. Nikolaeva, A.D. Alekseeva [et al.] // Yakut Medical Journal. – 2016. – Vol. 2 (14). – P. 90-93 (in Russ).
3. Kostin A.A. Multisystem atrophy. Urological features / A.A. Kostin, E.S. Korshunova //Materials of the 2nd scientific-practical conference of urologists of the North-West Federal District of the Russian Federation - 2016 – Vol. 6. – P. 61-62 (in Russ).
4. O.S. Levin. Parkinson's disease / Levin O.S., Fedorova N.V. – M.: MEDpress-inform. – 2012. – P. 213-234 (in Russ).
5. Martemyanova E.O. Methods for diagnosing MCA in early stages / E.O. Martemyanova // Psychiatry and Neurosciences. – 2018. (in Russ).
6. Multiple system atrophy of brain as most probable diagnosis in 60- year old patients with Parkinson syndrome of 10-year period / R.V. Simanov, S.K. Yevtushenko, V.A. Simonyan [et al.] // International Neurological Journal – 2012 – Vol.5 (51). – Р. 86-90 (in Russ).
7. Contemporary Concept of Multiple System Atrophy // M.V. Ershova, D.R. Akhmadullina, E.Yu. Fedotova [et al.] // Nervous diseases. – 2018 – Vol. 4. – Р. 3-13 (in Russ).
8. Clinical features and natural history of multiple system atrophy. The analysis of 100 cases / G. Wenning, Y. Ben Shlomo, M. Magalhaes [et al.] / Brain. – 1994. – Vol. 117(Pt 4). – P. 835-845.
9. European Multiple System Atrophy Study Group. The natural history of multiple system atrophy: a prospective European cohort study / G.K. Wenning, F. Geser, F. Krismer [et al.] // The Lancet. Neurology. – 2013. – Vol. 12(3). – P. 264-274.
10. Fanciulli A. Multiple system atrophy / A. Fanciulli, G. Wenning. // The New England Journal of Medicine. – 2015. – Vol. 372(3). – P. 249-263.
11. Krismer F. Multisystem atrophy: insights into a rare and debilitating motor disorder / F. Krismer, G. Wenning // Nature Reviews. Neurology. – 2017. – Vol. 13(4). – P. 232-243.
12. MSA-SG. Presentation, diagnosis, and management of multiple system atrophy in Europe: final analysis of the European multiple system atrophy registry / M. Köllensperger, F. Geser, J. Ndayisaba [et al.] // Movement Disorders. – 2010. – Vol. 25(15). – P. 2604-2612.
13. Multiple system atrophy / G. Wenning, C. Colosimo, F. Geser F [et al.] // The Lancet. Neurology. – 2004. – Vol. 3(2). – P. 93-103.
14. Natural history of multiple system atrophy in the USA: a prospective cohort study / P. Low, S. Reich, J. Jankovic [et al.] // The Lancet. Neurology. – 2015. – Vol. 14(7). – P. 710-719.
15. Progression and prognosis in multiple system atrophy. An analysis of 230 Japanese patients / H. Watanabe, Y. Saito, S. Terao [et al.] // Brain. – 2002. – Vol. 125(Pt 5). – P. 1070-1083.
16. Survival of patients with pathologically proven multiple system atrophy: a meta-analysis / Y. Ben-Shlomo, G. Wenning, F. Tison [et al.] // Neurology. – 1997. – Vol. 48(2). – P. 384-393.
17. When DLB, PD, and PSP masquerade as MSA: an autopsy study of 134 patients / S. Koga, N. Aoki, R. Uitti [et al] // Neurology. – 2015. – Vol. 85(5). – P. 404-412.
Review
For citations:
Adamova A.E., Tappakhov A.A., Davydova T.K., Popova T.E., Khabarova Yu.I. Difficulties in diagnosing multisystem atrophy at early stages (clinical observations). Yakut Medical Journal. 2020;(4):119-122. https://doi.org/10.25789/YMJ.2020.72.29
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