Biomarkers of epilepsy: microRNA
https://doi.org/10.25789/YMJ.2020.72.26
Abstract
This article considers the use of microRNAs as a possible biomarker of epilepsy.
The presented studies have shown that microRNAs can be involved in the process of epileptogenesis by regulating the inflammatory response, apoptosis of neurons, and transcription factors involved in cell differentiation. Biological fluids (blood and CSF) of patients with epilepsy showed differences in the number of circulating microRNAs, which may allow further use of microRNAs as a diagnostic biomarker. Recent discoveries providethe sufficient source of new microRNA targets, but there are still significant problems of studying their role in pathogenesis and the possibility of their application in clinical practice.
About the Authors
M. R. Sapronova
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Sapronova Margarita Rafailevna – Ph.D., associate Professor, Department of medical genetics and clinical neurophysiology
Krasnoyarsk
K. D. Yarovleva
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Yarovleva Kristina Dmitrievna – postgraduate student, laboratory assistant, Department of medical genetics and clinical neurophysiology
Krasnoyarsk
A. A. Usoltseva
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Usoltseva Anna Alexandrovna – the resident, laboratory assistant, Department of medical genetics and clinical neurophysiology
Krasnoyarsk
J. S. Panina
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Panina Julia Sergeevna – research scientist, Department of medical genetics and clinical neurophysiology of Institute of postgraduate education
Krasnoyarsk
D. V. Dmitrienko
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Dmitrienko Diana Viktorovna – MD, Ph. D., head of the Department of medical genetics and clinical neurophysiology
Krasnoyarsk
S. N. Zobova
Institute of postgraduate education V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University;
Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences, the Separate Division «Research Institute of Medical Problems of the North»
Russian Federation
Russian Federation
Zobova Svetlana Nikolaevna – Ph. D, research scientist, Department of medical genetics and clinical neurophysiology
Krasnoyarsk
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Review
For citations:
Sapronova M.R., Yarovleva K.D., Usoltseva A.A., Panina J.S., Dmitrienko D.V., Zobova S.N. Biomarkers of epilepsy: microRNA. Yakut Medical Journal. 2020;(4):106-111. https://doi.org/10.25789/YMJ.2020.72.26
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