Human papillomavirus as a factor in the development of cervical cancer
https://doi.org/10.25789/YMJ.2020.72.20
Abstract
The analysis of cytological samples of 100 women aged 23 to 60 years was carried out by liquid-based cytology. The predominance of NILM in the samples in comparison with intraepithelial lesions of the cervix was noted. Among intraepithelial lesions, low-grade LSIL was significantly more common. Positive HPV tests were found in less than half of the cases in tested women. Among the positive tests of high oncogenic risk the types 16 and 51 were considered as high-risk HPV types. There is approximately equal positivity of the high-risk HPV test in women with NILM and intraepithelial lesions (LSIL, HSIL, ASCUS). The positivity of the high-risk HPV test depends on age: in women under 45 years this indicator is higher than in women 46 years and older.
According to our survey, with cytological study it is necessary to apply integrated test approach when screening high-risk HPV infection. The combined use of liquid-based cytology and HPV testing can improve the effectiveness of diagnostics by reducing the amount of uninformative material and allows to detect pathological changes at an earlier stage. It will significantly increase the value of diagnostic measures and will improve cytologist’s experience in diagnosing and giving recommendations in clinical practice of cervical pathologies.
About the Authors
M. P. Kirillina
Yakut Science Centre of Complex Medical Problems;
NEFU Medical Institute Clinic Laboratory
Russian Federation
Russian Federation
Kirillina Maria Petrovna – Candidate of Biological Sciences, Senior Research Scientist, Head of the laboratory of precancerogenesis and malignant tumors;
Head
89142716881
I. V. Kononova
Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
Kononova Irina Vasilievna – Candidate of Medical Science, Research Worker at the laboratory of precancerogenesis and malignant tumors
89243683673
S. I. Sofronova
Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
Sofronova Sargylana Ivanovna – Candidate of Biological Sciences, Chief Research Worker, Head of research section
89841094825
P. M. Ivanov
Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
Ivanov Petr Mikhailovich – Candidate of Biological Sciences, Professor, Senior Scientist at the laboratory of precancerogenesis and malignant tumors
89148234539
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For citations:
Kirillina M.P., Kononova I.V., Sofronova S.I., Ivanov P.M. Human papillomavirus as a factor in the development of cervical cancer. Yakut Medical Journal. 2020;(4):82-86. https://doi.org/10.25789/YMJ.2020.72.20
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