Association analysis of amine oxidase 1 AOC1 and histamine-N-methyltransferase HNMT genes polymorphism with the development of asthma in children
O. N. Savelieva,
A. S. Karunas,
Yu. Yu. Fedorova,
R. F. Gatiyatullin,
E. I. Etkina,
E. K. Khusnutdinova https://doi.org/10.25789/YMJ.2020.72.05
Abstract
The significance of polymorphic variants of amino oxidase AOC1 and histamine-N-methyltransferase HNMT genes, involved in histamine metabolism, with predicting the risk of developing bronchial asthma (BA) in children living in the Republic of Bashkortostan was evaluated. Associations of the rs1049793 * CC genotype and the rs1049793 * C allele of the AOC1 gene with the development of ВА were revealed with significant reductions in spirography indices in children of Russian ethnicity. There were associations of the rs1801105 * CT genotype and the rs1801105 * T allele of the HNMT gene with a significant decrease in MEF25 in BA patients of Tatar ethnicity. The results of this study indicate the role of polymorphic variants of the AOC1 and HNMT genes in the development of BA.
Keywords
bronchial asthma,
polymorphic variant,
association,
amine oxidase gene AOC1,
gene of histamine-N-methyltransferase HNMT
Supporting agencies: The work was performed within the framework of the Ministry of Education and Science of the Russian Federation (№ AAAA-A16-116020350032-1), the FTP project № 05.621.21.0033 with the use of the equipment of the Regional center for collective use of unique equipment "Agidel", with partial support of the RFBR grants (project № 19-315-90055) and Saint Petersburg State University (grant ID 60238366/project ID 60257092).
About the Authors
O. N. Savelieva
Bashkir State University
Russian Federation
Russian Federation
Savelieva Olga Nikolaevna – Post-graduate student
450076, Ufa, st. Zaki Validi, 32
A. S. Karunas
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences;
Bashkir State Medical University;
Saint-Petersburg State University
Russian Federation
Russian Federation
Karunas Aleksandra Stanislavovna – Doctor of Biological Sciences, Candidate of Medical Sciences, Russian Academy of Education professor, Acting Director for science;
450054, Ufa, Pr. Oktyabrya, 71;
Professor of the Chair of Medical Genetics and Fundamental Medicine
450008, Ufa, ul. Lenina, 3;
Senior Researcher
ul. Universitetskaya embankment, 7/9; tel. +7 (347) 235-60-88
Yu. Yu. Fedorova
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences;
Saint-Petersburg State University
Russian Federation
Russian Federation
Fedorova Yuliya Yurievna – Candidate of Biological Sciences, Researcher
450054, Ufa, Pr. Oktyabrya, 71;
Researcher
ul. Universitetskaya embankment, 7/9; tel. +7(347) 235-60-88
R. F. Gatiyatullin
Bashkir State Medical University
Russian Federation
Russian Federation
Gatiyatullin Radik Fidagievich - Doctor of Medical Sciences, Professor, Professor of the Chair of Hospital Pediatrics
450008, Ufa, ul. Lenina, 3
E. I. Etkina
Bashkir State Medical University
Russian Federation
Russian Federation
Etkina Esfir Isaakovna - Doctor of Medical Sciences, Professor, Head of the Chair of Childhood Disorders
450008, Ufa, ul. Lenina, 3
E. K. Khusnutdinova
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences;
Saint-Petersburg State University
Russian Federation
Russian Federation
Khusnutdinova Elza Kamilevna - Doctor of Biological Sciences, Professor, Associate Member of the Academy of Education of Russian Federation, Director
450054, Ufa, Pr. Oktyabrya, 71;
Chief Researcher
ul. Universitetskaya embankment, 7/9
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For citations:
Savelieva O.N., Karunas A.S., Fedorova Yu.Yu., Gatiyatullin R.F., Etkina E.I., Khusnutdinova E.K. Association analysis of amine oxidase 1 AOC1 and histamine-N-methyltransferase HNMT genes polymorphism with the development of asthma in children. Yakut Medical Journal. 2020;(4):20-22. https://doi.org/10.25789/YMJ.2020.72.05
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