Preview

Yakut Medical Journal

Advanced search

Association analysis of amine oxidase 1 AOC1 and histamine-N-methyltransferase HNMT genes polymorphism with the development of asthma in children

https://doi.org/10.25789/YMJ.2020.72.05

Abstract

The significance of polymorphic variants of amino oxidase AOC1 and histamine-N-methyltransferase HNMT genes, involved in histamine metabolism, with predicting the risk of developing bronchial asthma (BA) in children living in the Republic of Bashkortostan was evaluated. Associations of the rs1049793 * CC genotype and the rs1049793 * C allele of the AOC1 gene with the development of ВА were revealed with significant reductions in spirography indices in children of Russian ethnicity. There were associations of the rs1801105 * CT genotype and the rs1801105 * T allele of the HNMT gene with a significant decrease in MEF25 in BA patients of Tatar ethnicity. The results of this study indicate the role of polymorphic variants of the AOC1 and HNMT genes in the development of BA.

About the Authors

O. N. Savelieva
Bashkir State University
Russian Federation

Savelieva Olga Nikolaevna – Post-graduate student

450076, Ufa, st. Zaki Validi, 32



A. S. Karunas
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Bashkir State Medical University; Saint-Petersburg State University
Russian Federation

Karunas Aleksandra Stanislavovna – Doctor of Biological Sciences, Candidate of Medical Sciences, Russian Academy of Education professor, Acting Director for science;

450054, Ufa, Pr. Oktyabrya, 71;

Professor of the Chair of Medical Genetics and Fundamental Medicine

450008, Ufa, ul. Lenina, 3;

Senior Researcher

ul. Universitetskaya embankment, 7/9; tel. +7 (347) 235-60-88



Yu. Yu. Fedorova
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Saint-Petersburg State University
Russian Federation

Fedorova Yuliya Yurievna – Candidate of Biological Sciences, Researcher

450054, Ufa, Pr. Oktyabrya, 71;

Researcher

ul. Universitetskaya embankment, 7/9; tel. +7(347) 235-60-88



R. F. Gatiyatullin
Bashkir State Medical University
Russian Federation

Gatiyatullin Radik Fidagievich - Doctor of Medical Sciences, Professor, Professor of the Chair of Hospital Pediatrics

450008, Ufa, ul. Lenina, 3



E. I. Etkina
Bashkir State Medical University
Russian Federation

Etkina Esfir Isaakovna - Doctor of Medical Sciences, Professor, Head of the Chair of Childhood Disorders

450008, Ufa, ul. Lenina, 3



E. K. Khusnutdinova
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Saint-Petersburg State University
Russian Federation

Khusnutdinova Elza Kamilevna - Doctor of Biological Sciences, Professor, Associate Member of the Academy of Education of Russian Federation, Director

450054, Ufa, Pr. Oktyabrya, 71;

Chief Researcher

ul. Universitetskaya embankment, 7/9



References

1. Kucher A.N. Genes of the Histamine Pathway and Common Diseases / A.N. Kucher, N.A. Cherevko // Russian Journal of Genetics. – 2018. – Vol. 54 (10). – P. 15-32. (in Russ.).] DOI: 10.7868/S0016675818010083

2. National program "Bronchial asthma in children. Treatment strategy and prevention". Chuchalin A.G. (Ed.). 5th ed. M: Original maket. 2017. 160 s. (in Russ.).

3. Association between two polymorphisms of histamine-metabolising enzymes and the severity of allergic rhinitis in a group of Mexican children / R. Meza-Velázquez, F. López-Márquez, S. Espinosa-Padilla [et al.] // Allergol. Immunopathol. (Madr). – 2016. – Vol. 44(5). – P. 433-8. DOI: 10.1016/j.aller.2016.01.002

4. Genetic variation in the histamine production, response, and degradation pathway is associated with histamine pharmacodynamic response in children with asthma / B.L. Jones, C.M.T. Sherwin, X. Liu [et al.] // Front. Pharmacol. – 2017. – Vol. 7. – P. 524. DOI: 10.3389/fphar.2016.00524

5. Genetic variation within the histamine pathway among patients with asthma / N. Raje, C.A. Vyhlidal, H. Dai [et al.] // J. Asthma. – 2015. – Vol. 52(4). – P. 353-362. DOI: 10.3109/02770903.2014.973501

6. Global Initiative for Asthma. Global strategy for asthma management and prevention. Updated 2020. – P. 1-209.

7. Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis / E. García-Martín, J. García-Menaya, B. Sánchez [et al.] // Clin. Exp. Allergy. – 2007. – Vol. 37(8). –P. 1175-1182. DOI: 10.1111/j.1365-2222.2007.02769.x

8. Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study / A. Szczepankiewicz, A. Breborowicz, P. Sobkowiak [et al.] // Clin. Mol. Allergy. – 2010. – Vol. 8. – P. 14. DOI: 10.1186/1476-7961-8-14


Review

For citations:


Savelieva O.N., Karunas A.S., Fedorova Yu.Yu., Gatiyatullin R.F., Etkina E.I., Khusnutdinova E.K. Association analysis of amine oxidase 1 AOC1 and histamine-N-methyltransferase HNMT genes polymorphism with the development of asthma in children. Yakut Medical Journal. 2020;(4):20-22. https://doi.org/10.25789/YMJ.2020.72.05

Views: 22


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1813-1905 (Print)
ISSN 2312-1017 (Online)