Association analysis of amine oxidase 1 AOC1 and histamine-N-methyltransferase HNMT genes polymorphism with the development of asthma in children
https://doi.org/10.25789/YMJ.2020.72.05
Abstract
The significance of polymorphic variants of amino oxidase AOC1 and histamine-N-methyltransferase HNMT genes, involved in histamine metabolism, with predicting the risk of developing bronchial asthma (BA) in children living in the Republic of Bashkortostan was evaluated. Associations of the rs1049793 * CC genotype and the rs1049793 * C allele of the AOC1 gene with the development of ВА were revealed with significant reductions in spirography indices in children of Russian ethnicity. There were associations of the rs1801105 * CT genotype and the rs1801105 * T allele of the HNMT gene with a significant decrease in MEF25 in BA patients of Tatar ethnicity. The results of this study indicate the role of polymorphic variants of the AOC1 and HNMT genes in the development of BA.
Keywords
About the Authors
O. N. SavelievaRussian Federation
Savelieva Olga Nikolaevna – Post-graduate student
450076, Ufa, st. Zaki Validi, 32
A. S. Karunas
Russian Federation
Karunas Aleksandra Stanislavovna – Doctor of Biological Sciences, Candidate of Medical Sciences, Russian Academy of Education professor, Acting Director for science;
450054, Ufa, Pr. Oktyabrya, 71;
Professor of the Chair of Medical Genetics and Fundamental Medicine
450008, Ufa, ul. Lenina, 3;
Senior Researcher
ul. Universitetskaya embankment, 7/9; tel. +7 (347) 235-60-88
Yu. Yu. Fedorova
Russian Federation
Fedorova Yuliya Yurievna – Candidate of Biological Sciences, Researcher
450054, Ufa, Pr. Oktyabrya, 71;
Researcher
ul. Universitetskaya embankment, 7/9; tel. +7(347) 235-60-88
R. F. Gatiyatullin
Russian Federation
Gatiyatullin Radik Fidagievich - Doctor of Medical Sciences, Professor, Professor of the Chair of Hospital Pediatrics
450008, Ufa, ul. Lenina, 3
E. I. Etkina
Russian Federation
Etkina Esfir Isaakovna - Doctor of Medical Sciences, Professor, Head of the Chair of Childhood Disorders
450008, Ufa, ul. Lenina, 3
E. K. Khusnutdinova
Russian Federation
Khusnutdinova Elza Kamilevna - Doctor of Biological Sciences, Professor, Associate Member of the Academy of Education of Russian Federation, Director
450054, Ufa, Pr. Oktyabrya, 71;
Chief Researcher
ul. Universitetskaya embankment, 7/9
References
1. Kucher A.N. Genes of the Histamine Pathway and Common Diseases / A.N. Kucher, N.A. Cherevko // Russian Journal of Genetics. – 2018. – Vol. 54 (10). – P. 15-32. (in Russ.).] DOI: 10.7868/S0016675818010083
2. National program "Bronchial asthma in children. Treatment strategy and prevention". Chuchalin A.G. (Ed.). 5th ed. M: Original maket. 2017. 160 s. (in Russ.).
3. Association between two polymorphisms of histamine-metabolising enzymes and the severity of allergic rhinitis in a group of Mexican children / R. Meza-Velázquez, F. López-Márquez, S. Espinosa-Padilla [et al.] // Allergol. Immunopathol. (Madr). – 2016. – Vol. 44(5). – P. 433-8. DOI: 10.1016/j.aller.2016.01.002
4. Genetic variation in the histamine production, response, and degradation pathway is associated with histamine pharmacodynamic response in children with asthma / B.L. Jones, C.M.T. Sherwin, X. Liu [et al.] // Front. Pharmacol. – 2017. – Vol. 7. – P. 524. DOI: 10.3389/fphar.2016.00524
5. Genetic variation within the histamine pathway among patients with asthma / N. Raje, C.A. Vyhlidal, H. Dai [et al.] // J. Asthma. – 2015. – Vol. 52(4). – P. 353-362. DOI: 10.3109/02770903.2014.973501
6. Global Initiative for Asthma. Global strategy for asthma management and prevention. Updated 2020. – P. 1-209.
7. Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis / E. García-Martín, J. García-Menaya, B. Sánchez [et al.] // Clin. Exp. Allergy. – 2007. – Vol. 37(8). –P. 1175-1182. DOI: 10.1111/j.1365-2222.2007.02769.x
8. Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study / A. Szczepankiewicz, A. Breborowicz, P. Sobkowiak [et al.] // Clin. Mol. Allergy. – 2010. – Vol. 8. – P. 14. DOI: 10.1186/1476-7961-8-14
Review
For citations:
Savelieva O.N., Karunas A.S., Fedorova Yu.Yu., Gatiyatullin R.F., Etkina E.I., Khusnutdinova E.K. Association analysis of amine oxidase 1 AOC1 and histamine-N-methyltransferase HNMT genes polymorphism with the development of asthma in children. Yakut Medical Journal. 2020;(4):20-22. https://doi.org/10.25789/YMJ.2020.72.05