Analysis of cortisol and dehydroepiandrosterone-sulfate levels in male northerners: the influence of generation living in the north
https://doi.org/10.25789/YMJ.2024.87.20
Abstract
The aim of the study is to identify regional characteristics and to assess changes in the mean level of cortisol and dehydropepenandrosterone-sulphate in male northerners according to the generation living in the North.
The total sample included male residents (average age 40.0 0.8 years) permanently residing in the territory of Magadan region.
The study has resulted in referring serum cortisol and dehydroepiandrosterone-sulfate concentrations, their ratio, as well as cortisol concentrations in the evening saliva tests to significant markers that reflect readjustments in the endocrine picture with increasing length of residence in the North, thus confirming the generally recognized role of glucocorticoids in hormonal support of the body adaptation to extreme factors including climatic environments.
About the Authors
I. V. Averyanova
Extreme Conditions Scientific Research Center “Arktika”, Fareastern Branch of the Russian Academy of Sciences (SRC “Arktika” FEB RAS)
Russian Federation
Russian Federation
Averyanova Inessa Vladislavovna – Doctor in Biology, head of the laboratory, chief researcher of the Laboratory of Physiology
O. O. Alyoshina
Extreme Conditions Scientific Research Center “Arktika”, Fareastern Branch of the Russian Academy of Sciences (SRC “Arktika” FEB RAS)
Russian Federation
Russian Federation
Alyoshina Olga Olegovna – junior scientist at the Laboratory of the Physiology
References
1. Averyanova IV, Maksimov AL Adaptation of functional systems in different generations of Caucasians in the North-East of Russia. Human Ecology. 2023. 30(4). P. 259-273. doi: 10.17816/humeco321856.
2. Volkova NI, Bichkaeva FA. Analysis of the blood serum content of adult Arctic and Arctic North // In the collection: Global Problems of the Arctic and Antarctic. Collection of scientific materials of All-Russia conference with international participation, dedicated to the 90th anniversary of academician Nikolay Pavlovich Laverov. Responsible editors: A.O. Gliko, A.A. Barah, K.V. Lobanov, I.N. Bolotov. 2020. P. 956-961.
3. Goncharov NP, Katsiya GV Dehydroepiandrosterone biosynthesis, metabolism, biological effects, and clinical use (analytical review) // Andrology and Genital Surgery. 2015. 16(1). P. 13–22. https://doi.org/10.17650/2070-9781-2015-1-13-22.
4. Zaichik ASh, Churilov LP. General pathophysiology (with the basics of immunopathology): Pathophysiology. In 3 volumes. Ed. 4th. SPb: JeLBI-SPb. 2008.
5. Maksimov AL, Bartosh TP. Variations of the norm of human hormonal status in the North-East of Russia: scientific –practical recommendations. Magadan: NESC FER RAS, 1995. 29 p.
6. Assessment of adaptive reserves of the body of men: theoretical basis, technology: methodological. A.M. Nikiforova MES Russia. / Aleksanin S.S., [et al. ] /SPB.: CPI «Izmaylovsky», 2022. 19 p.
7. Pirogov A.B. Neuroendocrine structure of adaptation of the Russian north-eastern population // Bulletin of physiology and respiratory pathology. 1998. 1. P. 14-27.
8. Levels of insulin, C-peptide, and hydrocortisone in the course of glucose tolerance test in indigenous population of the Extreme North and in newcomers/ Dogadin SA [et al] // Problems of Endocrinology. 1997. 43(2). P. 7–10
9. Khasnulin VI. Features of emotional stress in the residents of the north and siberian regions with discomfortable climate at high or low content of hormones in the blood // World of science, culture and education. 2012. 5(36). P. 32–35
10. Khasnulin VI, Khasnulin PV. Modern concepts of the mechanisms forming northern stress in humans in high latitudes // Human ecology. 2012. 1. P. 3–11
11. Adam EK, Kumari M Assessing salivary cortisol in large-scale, epidemiological research // Psychoneuroendocrinology. 2009;34:1423-1436. DOI: 10.1016/j.psyneuen.2009.06.011
12. Age-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates / Ferrari E [et al] // Eur J Endocrinol. 2001;144(4):319–329. DOI:10.1530/eje.0.1440319
13. Aldwin CM, Park CL, Spior A Handbook of Health Psychology and Aging, Guilford Publications, Inc, New York. 2007. P. 119-141 DOI:10.1348/000712607X246
14. Awakening responses and diurnal fluctuations of salivary cortisol, DHEA-S and α-amylase in healthy male subjects / Ghiciuc CM [et al] // Neuroendocrinol Lett. 2011;32(4): 475–480.
15. Clow Assessment of the cortisol awakening response: expert consensus guidelines /stalder T [et al] // Psychoneuroendocrinology. 2016;63:414-432. DOI: 10.1016/j.psyneuen.2015.10.010
16. Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study / Phillips AC [et al] // Eur J Endocrinol. 2010; 163(2): 285–292. DOI: 10.1530/EJE-10-0299
17. de Bruijn R, Romero LM The role of glucocorticoids in the vertebrate response to weather // General and Comparative Endocrinology. 2018;269:11-32, https://doi.org/10.1016/j.ygcen.2018.07.007.
18. Diurnal cortisol slopes and mental and physical health outcomes: a systematic review and meta-analysis / Adam EK [et al] // Psychoneuroendocrinology. 2017;83:25-41. DOI: 10.1016/j.psyneuen.2017.05.018
19. Diurnal patterns and associations among salivary cortisol, DHEA and alpha-amylase in older adults / Wilcox RR [et al] // Physiology & Behavior. 2014;129:11-16, https://doi.org/10.1016/j.physbeh.2014.02.012.
20. Do diurnal salivary cortisol curves carry meaningful information about the regulatory biology of the HPA axis in healthy humans? / Abelson JL, [et al] // Psychoneuroendocrinology. 2023. 150. https://doi.org/10.1016/j.psyneuen.2023.106031.
21. Homberger B, Jenni-Eiermann S, Jenni L Distinct responses of baseline and stress-induced corticosterone levels to genetic and environmental factors // General and Comparative Endocrinology.2015;210: 46-54. https://doi.org/10.1016/j.ygcen.2014.09.020.
22. Kamin HS, Kertes DA Cortisol and DHEA in development and psychopathology // Horm. Behav. 2017;89: 69–85. doi: 10.1016/j.yhbeh.2016.11.018.
23. King SL, Hegadoren KM Stress hormones: how do they measure up? // Biol Res Nurs 2002;4: 92–103.
24. McEwen BS Protective and damaging effects of stress mediators // N. Engl. J. Med, 1998;338: 171-179. DOI:10.1056/NEJM199801153380307
25. McEwen BS, Akil H Revisiting the stress concept: implications for affective disorders // J. Neurosci. 2020;40: 12-21. DOI:10.1523/JNEUROSCI.0733-19.2019
26. Møller N, Jørgensen JOL Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects // Endocr Rev. 2009;30:152-177. DOI:10.1210/er.2008-0027
27. Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) / Maninger N [et al] // Frontiers in Neuroendocrinology. 2009;30(1):65-91. https://doi.org/10.1016/j.yfrne.2008.11.002.
28. Obayashi K Salivary mental stress proteins // Clin Chim Acta. 2013;425:196–201. doi: 10.1016/j.cca.2013.07.028
29. Oyola MG, Handa RJ Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity // The International Journal on the Biology of Stress. 2017;20:1-19. DOI:10.1080/10253890.2017.1369523
30. Raised cortisol:DHEAS ratios in the elderly after injury: potential impact upon neutrophil function and immunity. / Butcher SK [et al] // Aging Cell. 2005;4(6):319–324. DOI:10.1111/j.1474-9726.2005.00178.x
31. Regulation of the hypothalamic-pituitary-adrenocortical stress response / Herman JP [et al] // Compr. Physiol. 2016;6:603-621. DOI:10.1002/cphy.c150015
32. Sapolsky RM, Romero LM, Munck AU How do glucocorticoids influence stress-responses? Integrating permissive, suppressive, stimulatory, and preparative actions// Endocrinol. Rev. 2000;21: 55-89. DOI:10.1210/edrv.21.1.0389
33. Wolkowitz OM, Epel ES, Reus VI Stress hormone-related psychopathology: pathophysiological and treatment implications // World J. Biol. Psychiatry. 2001;2:115-143, 10.3109/15622970109026799
Review
For citations:
Averyanova I.V., Alyoshina O.O. Analysis of cortisol and dehydroepiandrosterone-sulfate levels in male northerners: the influence of generation living in the north. Yakut Medical Journal. 2024;(3):99-103. https://doi.org/10.25789/YMJ.2024.87.20
Views:
29
Email this article 