EGFR mutations (DEL19/L858R) in lung adenocarcinoma in patients of the Yakut Republican Oncological Dispensary
Yu. N. Mikhailov,
E. V. Filippov,
G. V. Filippova,
F. G. Ivanova,
T. I. Nikolaeva,
P. V. Nikiforov,
L. N. Afanasyeva https://doi.org/10.25789/YMJ.2024.87.17
Abstract
The frequency of Del 19 and L858R mutations of the EGFR gene was studied among patients of the Yakut Republican Oncology Dispensary with lung adenocarcinoma (n=177). Mutations were found 3.8 times more commonly in female population than in male. Mutations were detected 2.8 times more regularly among patients with stages I and II of the disease in compare with stages III and IV. The mutation frequency was 3.4 times over in the Sakha (Yakut) ethnic group patients as opposed to Russian ethnic group. In addition the mutation frequency was 9.6 times over in the Sakha (Yakut) ethnic group male patients as opposed to Russian ethnic group. It was shown that the overall 36-month survival of patients with a positive status of EGFR mutations increases by 2.5 times (from 29.3% to 74.1%). Moreover in patients with stages I and II of the disease, survival rate increases by 1.4 times, in patients over 65 years old in 2.9 times, in female patients in 2.4 times.
About the Authors
Yu. N. Mikhailov
State Budgetary Institution of the Republic of Sakha (Yakutia) Yakut Republican Oncology Dispensary
Russian Federation
Russian Federation
Mikhailov Yury Nikolayevich – chemist-expert of the molecular-biological laboratory
E. V. Filippov
State Budgetary Institution of the Republic of Sakha (Yakutia) Yakut Republican Oncology Dispensary
Russian Federation
Russian Federation
Filippov Eduard Vasilievich – PhD in Biology, head of the molecular biology laboratory
G. V. Filippova
Yakut Republican Oncology Dispensary; Institute of biological problems of cryolithozone YRC SD RAS
Russian Federation
Russian Federation
Filippova Galina Valerievna – PhD in Biology, biologist, pat.-anatomist. lab. Yakut Republican Oncology Dispensary, researcher of the Institute of biological problems of cryolithozone YRC SD RAS
F. G. Ivanova
State Budgetary Institution of the Republic of Sakha (Yakutia) Yakut Republican Oncology Dispensary
Russian Federation
Russian Federation
Ivanova Feodosiya Gavrilevna – head of the drug department
T. I. Nikolaeva
Yakut Republican Oncology Dispensary; M.K. Ammosov NEFU
Russian Federation
Russian Federation
Nikolaeva Tatiana Ivanovna – PhD in Medical sciences, head doctor SBI Yakut Republican cancer dyspensary, associate professor of M.K. Ammosov NEFU
P. V. Nikiforov
Yakut Republican Medical Information and Analytical Center; M.K. Ammosov NEFU
Russian Federation
Russian Federation
Nikiforov Petr Vladimirovich – Director of Yakut Republican Medical Information and Analytical Center, Associate Professor of M.K. Ammosov NEFU.
L. N. Afanasyeva
M.K. Ammosov NEFU
Russian Federation
Russian Federation
Afanasieva Lena Nikolayevna – MD, associate professor of M.K. Ammosov NEFU
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Review
For citations:
Mikhailov Yu.N., Filippov E.V., Filippova G.V., Ivanova F.G., Nikolaeva T.I., Nikiforov P.V., Afanasyeva L.N. EGFR mutations (DEL19/L858R) in lung adenocarcinoma in patients of the Yakut Republican Oncological Dispensary. Yakut Medical Journal. 2024;(3):83-88. https://doi.org/10.25789/YMJ.2024.87.17
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