Cellular and molecular mechanisms of neurosteroids in various parts of the central nervous system of rats (part I)
https://doi.org/10.25789/YMJ.2021.74.30
Abstract
Neuroactive steroids are a class of endogenous steroids synthesized in the nervous tissue and / or capable of having a modulating effect on its functional activity in the brain. The first part of the review is devoted to the little-studied genomic and non-genomic mechanisms of action of pregnenolone, pregnenolone sulfate, and their synthetic analogs, and to the identification of peculiarities of the secretion of pregnenolone and its metabolite in various parts of the central nervous system of rats in the ontogenetic aspect. A number effects of pregnenolone and pregnenolone sulfate are presented, such as modulation of NMDA, GABAA, kainate and AMPA receptors, voltage-dependent Ca2+ channels in vitro and in vivo, etc., an attempt was made to systematize the main effects of neurosteroids depending on the central nervous system.
About the Authors
D. V. Dmitrenko
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Dmitrenko Diana Viktorovna - Advanced Doctor in Medical Sciences, head of medical genetics and clinical neurophysiology department
S. N. Zobova
Scientific Research Institute of Medical Problems of the North FRC Krasnoyarsk Scientific Centre SB RAS
Russian Federation
Russian Federation
Zobova Svetlana Nikolaevna - Ph.D. of Medical Sciences, research officer
T. G. Ruksha
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Ruksha Tatyana Gennadievna - Advanced Doctor in Medical Sciences, professor, head of pathophysiology and clinical pathophysiology department
T. I. Prusova
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Prusova Tatyana Igorevna - student, laboratory assistant of medical genetics and clinical neurophysiology department
A. A. Usoltseva
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Usoltseva Anna Alexandrovna - clinical resident, laboratory assistant of medical genetics and clinical neurophysiology department
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Review
For citations:
Dmitrenko D.V., Zobova S.N., Ruksha T.G., Prusova T.I., Usoltseva A.A. Cellular and molecular mechanisms of neurosteroids in various parts of the central nervous system of rats (part I). Yakut Medical Journal. 2021;(2):116-120. https://doi.org/10.25789/YMJ.2021.74.30
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