HDV infection: a predictor of severe liver fibrosis (literature review)
https://doi.org/10.25789/YMJ.2021.74.29
Abstract
The epidemiological and pathogenetic aspects of HDV infection have been studied using the example of the Republic of Sakha (Yakutia). In addition to the genetic characteristics of the virus, the role of interferon genes in the formation of liver fibrosis was noted, due to their binding to the receptors of host cells and their influence on the process of viral reproduction within the cell. The results of clinical studies indicate their predictive effects among Asian populations (Japan, China, Taiwan). Taking into account the above data, the clinical and epidemiological situation for hepatitis D can serve as a subject of studying the impact of the virus genotype and polymorphisms of candidate genes on the formation of HDV-associated hepatocellular carcinoma, as well as probability of achieving a sustainable viral response and / or spontaneous clearance in patients with different rates of progression of the liver disease.
About the Authors
O. M. Zamorschikova
North-Eastern Federal University named after M.K. Ammosov, Institute of Medicine
Russian Federation
Russian Federation
Zamorschikova Olga Mikhailovna – Postgraduate student of Infectious Diseases, phthisiology and dermatovenerology Department
Yakutsk
S. S. Sleptsova
North-Eastern Federal University named after M.K. Ammosov, Institute of Medicine
Russian Federation
Russian Federation
Sleptsova Snezhana Spiridonovna – Doctor of Med. Sci., assistant professor, Head of Infectious Diseases, phthisiology and dermatovenerology Department
Yakutsk
S. S. Sleptsov
Yakutian Science Center of complex medical problem
Russian Federation
Russian Federation
Sleptsov Spiridon Spiridonovich – Cand. of Biol. Sci., assistant professor, senior researcher of clinic-populational and medico-social researches laboratory
Yakutsk
S. I. Malov
Irkutsk State Medical University
Russian Federation
Russian Federation
Malov Sergey Igorevich - Cand. of Med. Sci., assistant of Infectious Diseases Department
Irkutsk
+7(908)66264
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Review
For citations:
Zamorschikova O.M., Sleptsova S.S., Sleptsov S.S., Malov S.I. HDV infection: a predictor of severe liver fibrosis (literature review). Yakut Medical Journal. 2021;(2):113-115. https://doi.org/10.25789/YMJ.2021.74.29
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