Preview

Yakut Medical Journal

Advanced search

Testosterone levels and body mass index in young people in Yakutia

https://doi.org/10.25789/YMJ.2021.76.14

Abstract

The purpose of this study was to assess the levels of testosterone in the blood serum depending on the body mass index (BMI) in young men in Yakutia. It was found that in overweight individuals, testosterone levels were significantly lower, compared with those who had underweight or normal weight. A comparative analysis of testosterone levels according to global data confirmed the inverse correlation of testosterone levels with BMI. The heterogeneity of the studies was within the average heterogeneity, which may indicate a negative correlation of testosterone levels with BMI, regardless of race and ethnicity.

About the Authors

A. A. Nikanorova
Federal State Budgetary Scientific Institution "Yakut Science Center of Complex Medical Problems"
Russian Federation

Nikanorova Alеna Afanasyevna – junior researcher, Laboratory of Molecular Genetics

Yakutsk



N. A. Barashkov
Federal State Budgetary Scientific Institution "Yakutsk Scientific Center of Complex Medical Problems"
Russian Federation

Barashkov Nikolay Alekseevich – Candidate of Biological Sciences, Head of laboratory of Molecular genetics



S. S. Nakhodkin
Federal State Autonomous Educational Institution of Higher Education "North-Eastern Federal University M.K. Ammosov"
Russian Federation

Nakhodkin Sergey Sergeyevich – scientific researcher of the Research Laboratory of Molecular Biology Institute of Natural Sciences



V. G. Pshennikova
Federal State Budgetary Scientific Institution "Yakutsk Scientific Center for Complex Medical Problems
Russian Federation

Pshennikova Vera Gennadievna – Candidate of Biological Sciences, Head of laboratory of Populational Genetics



N. N. Gotovtsev
Federal State Budgetary Scientific Institution "Yakut Science Center of Complex Medical Problems"
Russian Federation

Gotovtsev Nyurgun Naumovich –scientific researcher, Laboratory of Molecular Genetics



S. S. Kuzmina
The Institute of Natural Sciences "North-Eastern Federal University M.K. Ammosov"
Russian Federation

Kuzmina Sargylana Semenovna – Candidate of Biological Sciences, Associate Professor, Department of Biology



N. N. Sazonov
The Institute of Natural Sciences "North-Eastern Federal University M.K. Ammosov"
Russian Federation

Sazonov Nikolay Nikitich – Doctor of biological sciences, Professor, Department of Biology



S. A. Fedorova
Federal State Autonomous Educational Institution of Higher Education "North-Eastern Federal University M.K. Ammosov"
Russian Federation

Fedorova Sardana Arkadievna – Doctor of biological sciences, Head of the Research Laboratory of Molecular Biology Institute of Natural Sciences



References

1. Hormonal profile and sperm quality in men of Eastern Siberia / Osadchuk L.V., Kleshchev M.A., Gutorova N.V. [et al.] // Bulletin of the Russian Academy of Medical Sciences. 2012: 67(3).

2. Changes in hormonal and metabolic status in men of an ethnic group Komi with overweight and obesity / Osadchuk L.V., Gutorova N.V., Ludinina A.Y., [et al.]//Obesity and metabolism. -2013: -10(2)

3. Study of spermatogenesis and hormonal status indicators in young men of Western Siberia / Osadchuk L.V., Kuznetsova N.N., Kleshchev M.A. [et al.] // Experimental and clinical urology. -2016. -4.

4. Assessment of the psychoemotional state and level of cortisol and testosterone in the pre-competition period in athletes of Yakutia / Okhlopkova E.D., Alekseeva Z.N., Efremova S.D. [et al.]// Yakut medical journal. -2020: -2: -С. 37-40.

5. Popova A.V. The relationship of obesity with the main reproductive indicators in male residents of Novosibirsk //Obesity and metabolism. -2012: 4(33).

6. A comparison of the hormonal profile of early androgenetic alopecia in men with the phenotypic equivalent of polycystic ovarian syndrome in women / Sanke S., Chander R., Jain A. [et al.] // JAMA dermatology. 2016: 152 (9): 986-991.

7. Acute effects of high-intensity interval, resistance or combined exercise protocols on testosterone–cortisol responses in inactive over-weight individuals / Velasco-Orjuela G.P., Domínguez-Sanchéz M.A. [et al.] //Physiology & behavior. 2018: 194: 401-409.

8. Andersen A.E., Wirth J.B., Strahlman E.R. Reversible weight-related increase in plasma testosterone during treatment of male and female patients with anorexia nervosa //International Journal of Eating Disorders. 1982: 1(2): 74-83.

9. Barker L.A., Gout B.S., Crowe T.C. Hospital malnutrition: prevalence, identification and impact on patients and the healthcare system //International journal of environmental research and public health. 2011: 8(2): 514-527.

10. Black R.E., Morris S.S., Bryce J. Where and Why are 10 Million Children Dying Every Year? // The Lancet. 2003: 361: 2226–34.

11. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis / Sermondade N., Faure C., Fezeu L. [et al.] // Human reproduction update. 2013: 19(3): 221-231.

12. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic / Chavarro J.E., Toth T.L., Wright D.L. [et al.] // Fertil Steril. 2010: 93(7): 2222–2231.

13. Bone mass and mineral metabolism in Klinefelter's syndrome / Luisetto G., Mastrogiacomo I., Bonanni G. [et al.] // Osteoporosis international. 1995: 5(6): 455-461.

14. Chandra R.K., Kumari S. Nutrition and immunity: an overview //The Journal of nutrition. 1994: 124(8): 1433S-1435S.

15. Excess deaths associated with underweight, overweight and obesity / Flegal K.M., Graubard B.I., Williamson D.F. [et al.] // JAMA. 2005: 293: 1861-7.

16. Fui M.N.T., Dupuis P., Grossmann M. Lowered testosterone in male obesity: mechanisms, morbidity and management // Asian journal of andrology. 2014: 16(2): 223.

17. Greater secretion of growth hormone in black than in white men: possible factor in greater bone mineral density--a clinical research center study / Wright N.M., Renault J., Willi S. [et al.] // The Journal of Clinical Endocrinology & Metabolism. 1995: 80(8): 2291-2297.

18. Hypothalamic-pituitary-testicular axis and seminal parameters in hyperthyroid males / Abalovich M., Levalle O., Hermes R. [et al.] //Thyroid. 1999: 9: 857-863.

19. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study / Wu F.C., Tajar A., Pye S.R. [et al.] // The Journal of Clinical Endocrinology & Metabolism. 2008: 93(7): 2737-2745

20. Impact of body mass index, age and varicocele on reproductive hormone profile from elderly men/ Yamaçake K.G.R., Cocuzza M., Torricelli F.C.M. [et al.] //International braz j urol. 2016: 42: 365-372.

21. Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men / Roy T.A., Blackman M.R., Harman S.M. //American Journal of Physiology-Endocrinology and Metabolism. 2002: 283(2): E284-E294.

22. IOC consensus statement on relative energy deficiency in sport (RED-S): 2018 update / Mountjoy M., Sundgot-Borgen J.K., Burke L.M. [et al.] //British journal of sports medicine. 2018: 52(11): 687-697.

23. Low serum testosterone and sex-hormone-binding-globulin in massively obese men / Glass A.R., Swerdloff R.S., Bray G.A. [et al.]//J Clin Endocrinol Metab. 1977: 45: 1211-9.

24. Male obesity and alteration in sperm parameters / Hammoud A.O., Wilde N., Gibson M. [et al.] // Fertility and sterility. 2008: 90(6): 2222-2225.

25. Maternal and child undernutrition and overweight in low-income and middle-income countries / Black R.E., Victoria C.G., Walker S.P. [et al.] //The lancet. 2013: 382: 427-451.

26. Mechanical muscle function and lean body mass during supervised strength training and testosterone therapy in aging men with low-normal testosterone levels / Kvorning T., Christensen L.L., Madsen K. [et al.] //Journal of the American Geriatrics Society. 2013: 61(6): 957-962.

27. Racial variation in sex steroid hormone concentration in black and white men: a meta-analysis. / Richard A., Rohrmann S., Zhang L. [et al.] //Andrology. 2014: 3: 428-435.

28. Reduced serum testosterone and prolactin levels in male distance runners / Wheeler G.D., Wall S.R., Belcastro A.N. [et al.] // Jama. 1984: 252(4): 514-516.

29. Reference intervals for important serum sex steroid hormones, prostate-specific antigen, insulin-like growth factor-1 and IGF binding protein-3 concentration in a normal Kuwaiti adult male population / Kehinde E.O., Akanji A.O., Mojiminiyi O.A. [et al.] //Medical principles and practice. 2005: 14(5): 342-348.

30. Resistance training increases SHBG in overweight/obese, young men / Roberts C.K., Croymans D.M., Aziz N. [et al.] // Metabolism. 2013: 62(5): 725-733.

31. Ross P.D. Osteoporosis: frequency, consequences, and risk factors //Archives of internal medicine. 1996: 156(13): 1399-1411.

32. Serum androgen concentrations in young men: A longitudinal analysis of associations with age, obesity, and race: The CARDIA male hormone study /Gapstur S.M., Gann P.H., Kopp P. [et al.]//Cancer Epidemiology and Prevention Biomarkers. 2002: 11: 1041-1047.

33. Strauss J., Thomas D. Health, nutrition, and economic development //Journal of economic literature. 1998: 36(2): 766-817.

34. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline / Bhasin S., Cunningham G.R., Hayes F.J. [et al.] // The Journal of Clinical Endocrinology & Metabolism. 2010: 95(6): 2536-2559.

35. The differences between aromatizable and non-aromatizable androgens in relation to body composition and metabolic syndrome risk factors in men / Pospíšilová H., Vaňková M., Hill M. [et al.]//The Journal of steroid biochemistry and molecular biology. 2012: 132(2): 105-111.

36. Wesselius C.L., Anderson G.A case study of a male with anorexia nervosa and low testosterone levels //The Journal of clinical psychiatry. 1982: 43(10): 428-429.

37. WHO. Physical Status: The Use and Interpretation of Anthropometry: Report of a World Health Organization (WHO) Expert Committee. Geneva, Switzerland: World Health Organization. 1995.


Review

For citations:


Nikanorova A.A., Barashkov N.A., Nakhodkin S.S., Pshennikova V.G., Gotovtsev N.N., Kuzmina S.S., Sazonov N.N., Fedorova S.A. Testosterone levels and body mass index in young people in Yakutia. Yakut Medical Journal. 2021;(4):60-64. https://doi.org/10.25789/YMJ.2021.76.14

Views: 18


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1813-1905 (Print)
ISSN 2312-1017 (Online)