Determination of the pharmacokinetic parameters of isoniazid using high performance liquid chromatography in patients with pulmonary tuberculosis
https://doi.org/10.25789/YMJ.2021.76.12
Abstract
The equilibrium plasma concentration of isoniazid in patients with pulmonary tuberculosis living in the Republic of Sakha (Yakutia) was determined by the method of high performance liquid chromatography. The high individual variability of pharmacokinetic parameters was confirmed : the maximum equilibrium concentration of the drug, the area under the pharmacokinetic curve, the average stationary concentration of the drug, the degree of fluctuation in the concentration of isoniazid in the blood plasma of patients with tuberculosis. Individual differences in the pharmacokinetic parameters of isoniazid indicate the need for therapeutic drug monitoring when prescribing isoniazid.
About the Authors
V. M. Nikolaev
Yakut Scientific Center of Complex Medical Problems
Russian Federation
Russian Federation
Nikolaev Vyacheslav Mikhailovich – Candidate of Biological Sciences, Head of the Department for the Study of Adaptation Mechanisms
6/3 Yaroslavsky str., Yakutsk, 677000, tel: +7(4112) 31-93-94
N. M. Krasnova
North-Eastern Federal University named after M.K. Ammosov
Russian Federation
Russian Federation
Krasnova Natalia Mikhailovna – Candidate of Medical Sciences, Associate Professor of the Department "Hospital Therapy, Occupational Diseases and Clinical Pharmacology, Medical Institute
677000, Yakutsk, Belinsky 58 str., tel.: +7 (914) 109-40-22
S. I. Sofronova
Yakut Scientific Center of Complex Medical Problems
Russian Federation
Russian Federation
Sofronova Sargylana Ivanovna, Candidate of Medical Sciences, Head of the Scientific-organizational and Information-Publishing Department
6/3 Yaroslavsky str., Yakutsk, 677000, tel.: +7(4112) 31-93-94
E. S. Prokopyev
Scientific and Practical Center "Phthisiology" named after E.N. Andreev
Russian Federation
Russian Federation
Prokopyev Egor Spiridonovich, Director
677015, Yakutsk, ul. Peter Alekseev, 93, tel.: +7 (4112) 39-03-30
A. F. Kravchenko
Scientific and Practical Center "Phthisiology"
Russian Federation
Russian Federation
Kravchenko Aleksandr Fedorovich – Doctor of Medical Sciences, Deputy Director for Outpatient Medical Care
677015, Yakutsk, ul. Peter Alekseeva, 93, tel.: +7 (4112) 39-03-30
D. A. Sychev
Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Sychev Dmitry A. – Doctor of Medical Sciences, Professor, Corresponding member RAS, RAS professor, Rector
2/1 Barrikadnaya str., building 1, Moscow, 125993, tel.: +7 (495) 680-05-99
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Review
For citations:
Nikolaev V.M., Krasnova N.M., Sofronova S.I., Prokopyev E.S., Kravchenko A.F., Sychev D.A. Determination of the pharmacokinetic parameters of isoniazid using high performance liquid chromatography in patients with pulmonary tuberculosis. Yakut Medical Journal. 2021;(4):52-56. https://doi.org/10.25789/YMJ.2021.76.12
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