Treatment of chronic arterial hypertension during pregnancy: the influence of the start time on the state of target organs
https://doi.org/10.25789/YMJ.2021.76.08
Abstract
The results of a comparative analysis of the effect of the timing of the start of antihypertensive therapy on the state of target organs (left ventricular (LV) myocardium, kidneys) in pregnant women with chronic arterial hypertension (CAH) and with the development of preeclampsia (PE) on its background are presented.
Early antihypertensive therapy makes it possible to implement a protective effect on the target organs of pregnant women with CAH (adaptive remodeling of the LV myocardium, renal endothelium (MAU) and purine metabolism (synthesis of uric acid)). Delayed hypotensive therapy (after 15-20 weeks of pregnancy) contributes to the dominance of maladaptive mechanisms of regulating the activity of the cardiovascular system. These pregnant women are distinguished by the progression of morphofunctional changes in the LV myocardium (concentric hypertrophy and diastolic dysfunction), to the greatest extent with the development of PE. The highest frequency of disturbances in the circadian rhythm of blood pressure (non-dipper and night-picker types) and metabolic changes (hyperuricemia, MAU) was revealed in pregnant women with the development of PE.
About the Authors
B. M. Gasanova
Federal State Autonomous State Educational Institution of Higher Education «People's Friendship University of Russia»Moscow
Russian Federation
Russian Federation
Gasanova Bakhtykei Musalavovna – PhD in Medical Sciences, Doctoral Candidate of the Department of Obstetrics and Gynaecology with a course in Perinatology of the Medical Institute
Moscow
M. L. Polina
Women's Health Medical Center
Russian Federation
Russian Federation
Polina Miroslava Leonidovna – PhD in Medical Sciences, Gynecologist
Moscow
N. I. Douglas
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Douglas Natalya Ivanovna – Grand PhD in Medical Sciences, Head of the Department of Obstetrics and Gynecology, Medical Institute
Yakutsk
P. N. Zakharova
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Zakharova Praskovya Nikolaevna – clinical resident of the Department of Obstetrics and Gynecology, Medical Institute
Yakutsk
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Review
For citations:
Gasanova B.M., Polina M.L., Douglas N.I., Zakharova P.N. Treatment of chronic arterial hypertension during pregnancy: the influence of the start time on the state of target organs. Yakut Medical Journal. 2021;(4):34-38. https://doi.org/10.25789/YMJ.2021.76.08
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