Evaluation of the mutagenic properties of the furocoumarin extract from the cell culture of Conium maculatum L.
https://doi.org/10.25789/YMJ.2021.76.06
Abstract
The genotoxicity of an extract from the cell culture of hemlock spotted in vivo in metaphase bone marrow plates of CBA mice and somatic cells of D. melanogaster, standardized by the amount and ratio of furocoumarins was studied. It was determined that using of the hemlock spotted cell culture extract does not induce genetic damage in CBA and D. melanogaster mice , which is one of the objective criteria for its safety. The results obtained determine possible prospects for continuing research in terms of developing a new herbal medicinal product.
About the Authors
O. V. Neupokoeva
RIofPRM named. E. D. Goldberg
Russian Federation
Russian Federation
Neupokoeva Oksana Vladimirovna – Ph.D., junior researcher in Laboratory of Drug Toxicology RIofPRM, TNRMC
O. L. Voronova
RIofPRM named E. D. Goldberg
Russian Federation
Russian Federation
Voronova Olga Leonidovna – Ph.D., Senior Researcher in Laboratory of Drug Toxicology, RIofPRM, TNRMC
E. P. Fedorova
RIofPRM named E. D. Goldberg
Russian Federation
Russian Federation
Fedorova Elena Pavlovna – Ph.D., Researcher in Laboratory of Drug Toxicology, RIofPRM, TNRMC
M. V. Filonova
RIofPRM named E. D. Goldberg; NI TSU
Russian Federation
Russian Federation
Filonova Maria Vasilievna – Research Assistant, Laboratory of Drug Toxicology, RIofPRM, TNRMC
A. A. Churin
RIofPRM named E. D. Goldberg; NI TSU
Russian Federation
Russian Federation
Churin Alexey Alexandrovich – MD, DSc, Head of the Department of Drug Toxicology, RIofPRM, TNRMC
V. V. Udut
RIofPRM named E. D. Goldberg; NI TSU
Russian Federation
Russian Federation
Udut Vladimir Vasilievich – Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences, Deputy Director for Scientific and Medical Work, Head of the Laboratory of Physiology, Molecular and Clinical Pharmacology, RIofPRM, TNRMC
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Review
For citations:
Neupokoeva O.V., Voronova O.L., Fedorova E.P., Filonova M.V., Churin A.A., Udut V.V. Evaluation of the mutagenic properties of the furocoumarin extract from the cell culture of Conium maculatum L. . Yakut Medical Journal. 2021;(4):27-30. https://doi.org/10.25789/YMJ.2021.76.06
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