Effect of hypothermia of the rat cerebral microvascular reactions under conditions of hemodynamic stability and blood loss
https://doi.org/10.25789/YMJ.2021.76.05
Abstract
This research studies the reaction of microcirculation of the cerebral cortex of rats with hemodynamic stability and the blood loss, with continuous exposure to decreasing body temperature till to the hypothermal arrest of the animal's breathing. The results were obtained that in the group of animals without hemorrhage, the cooling led to an initial short-term vasodilation and subsequent vasoconstriction up to 10-20% of the norm. In the group of animals with a pre-caused by hemorrhage, the narrowing of the vessels was 20% at the normothermia and intensified during the animal immersion in water on 35% of the initial state of the vessels. However, the functional state of the animal during blood loss and the subsequent cooling slightly differed from the normovolemic state of the body under hypothermic influence.
About the Author
N. N. Melnikova
I.P.Pavlov Institute of Physiology RAS
Russian Federation
Russian Federation
Melnikova Nadezhda Nikolaevna – Ph.D., Senior Researcher
Researcher-ID: J-8599-2018
St. Petersburg
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Review
For citations:
Melnikova N.N. Effect of hypothermia of the rat cerebral microvascular reactions under conditions of hemodynamic stability and blood loss. Yakut Medical Journal. 2021;(4):23-27. https://doi.org/10.25789/YMJ.2021.76.05
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