Vascular dysfunction factors in smokers with early stages of COPD and AH
https://doi.org/10.25789/YMJ.2021.76.04
Abstract
Systemic and topical markers of cardiovascular remodeling were determined in individuals with a history of smoking and early stages of arterial hypertension (AH) and COPD by assessing serum levels of growth factors (TGF-β, VEGF, ST-2 protein) and endothelin, as well as duplex scanning of the carotid arteries and strain echocardiography. Of the studied systemic markers of cardiovascular remodeling in the early stages of COPD and hypertension in active smokers VEGF and ET-1 are the most significant determinants. Despite the absence of differences in lipid metabolism between the examined groups, it is smokers with COPD and hypertension who have more pronounced signs of atherosclerosis in carotid arteries. Also, in the early stages of COPD and AH, disorders of local myocardial contractility are observed. Topical changes in vessels of the elastic type and myocardium in smokers with COPD and AH have a relationship in smokers of all groups with ST2 content, in patients with COPD and AH with VEGF levels.
About the Authors
E. A. Kondrashova
Institute of Therapy and Instrumental Diagnostics Pacific State Medical University, Healthcare Ministry of Russia; "Vladivostok Clinical Hospital No.1" Regional Healthcare Institution
Russian Federation
Russian Federation
Kondrashova Elena A. – assistant; ultrasound doctor
V. A. Nevzorova
Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
Nevzorova Vera A. – Doctor of Medicine, Professor, Director
N. V. Zaharchuk
Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
Zaharchuk Natalia V. – Doctor of Medicine, associate professor
References
1. Bogdanov DJu, Kondrashova EA, Kulakova NV. Risk factors' characteristics of cardiovascular disease in the population of Primorsk Region residents depending on the status of smoking and age (according to the data of the epidemiological study of ESSE-RF). Tihookeankiy medicinskiy zhurnal. 2017;(4):45-50.
2. Rotar OP, Tolkunova KM. EVA and SUPERNOVA concepts of vascular aging: ongoing research on damaging and protective risk factors. Arterial Hypertension. 2020;26(2):133-145. DOI:10.18705/1607-419Х-2020-26-2-133-145
3. Barnett K, Mercer SW, Norbury M, et al. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet 2012; 380: 37–43
4. Cevenini E, Monti D, Franceschi C. Inflamm-ageing. Curr Opin Clin Nutr Metab Care 2013; 16: 14–20; Ichimaru Y, Krimmer DI, Burgess JK, et al. TGF-β enhances deposition of perlecan from COPD airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2012; 302: L325–L333]
5. Ichimaru Y, Krimmer DI, Burgess JK, et al. TGF-β enhances deposition of perlecan from COPD airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2012; 302: L325–L333;
6. Mercado N, Thimmulappa R, Thomas CM, et al. Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. Biochem Biophys Res Commun 2011; 406: 292–298
7. Nilsson PM. Hemodynamic aging as the consequence of structural changes associated with early vascular aging. (EVA). Aging Dis 2014; 5: 109–113
8. Ogger PP, Silva JD, Aghapour M, et al. Early Career Members at the ERS Lung Science Conference 2020: metabolic alterations in lung ageing and disease. Breathe 2020; 16: 200063.
9. Peter J. Barnes European Respiratory Journal 2015 45: 790-806; DOI: 10.1183/09031936.00229714
10. Robert L. Aging of the vascular wall and atherogenesis: role of the elastini-laminin receptor. Atherosclerosis 1996; Cheitlin MD. Cardiovascular physiology-changes with aging. Am J Geriatr Cardiol 2003; 12: 9–13 123: 169–179. Nilsson PM. Hemodynamic aging as the consequence of structural changes associated with early vascular aging. (EVA). Aging Dis 2014; 5: 109–113
11. Shelton DN, Chang E, Whittier PS, et al. Microarray analysis of replicative senescence. Curr Biol 1999; 9: 939–945. Peter J. Barnes Mechanisms of development of multimorbidity in the elderly. European Respiratory Journal 2015 45: 790-806
12. Vanfleteren LE, Spruit MA, Groenen M, et al. Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 187: 728–735
13. William MacNee, Roberto A. Rabinovich and Gourab Choudhury. Ageing and the border between health and disease. Eur Respir J 2014; 44: 1332–1352. Peter J. Barnes Mechanisms of development of multimorbidity in the elderly. European Respiratory Journal 2015 45: 790-806; DOI: 10.1183/09031936.00229714
14. World Health Organization. Ageing and Life Course. Care and independence in older age. www.who.int/ageing/en Date of last access: July 2021
Review
For citations:
Kondrashova E.A., Nevzorova V.A., Zaharchuk N.V. Vascular dysfunction factors in smokers with early stages of COPD and AH. Yakut Medical Journal. 2021;(4):20-22. https://doi.org/10.25789/YMJ.2021.76.04
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