Prevalence of East Asian (East CagA) and Western variants of the cagA (Western cagA) gene of Helicobacter pylori in Yakutia
https://doi.org/10.25789/YMJ.2021.74.16
Abstract
The results of studying the prevalence of East Asian and Western variants of the cagA gene among Helicobacter pylori strains in Yakutia are presented. In the studied sample of Helicobacter pylori (H. pylori) DNA samples isolated from biopsies of patients with gastroduodenal diseases, western variants of the cagA gene (Western cagA) are prevailing, while East Asian variants of the cagA gene (East Asian cagA) were not found. The rest of the samples do not belong to either the Western (Western cagA) or the East Asian (East Asian cagA) variant of the cagA gene, which may indicate the presence of specific local variants of the cagA gene among H. pylori strains circulating in Yakutia.
Keywords
Helicobacter pylori,
East Asian cagA (East Asian cagA),
western cagA (Western cagA),
EPIYA motif,
Yakutia
Supporting agencies: The study was supported by the YSC KMP "Study of the genetic structure and burden of hereditary pathology of populations in the Republic of Sakha (Yakutia)" and the basic part of the state assignment of the Ministry of Science and Education of the Russian Federation (FSRG-2020-0016).
About the Authors
N. N. Gotovtsev
Federal State Budgetary Scientific Institution "Yakut Science Centre of complex medical problems"
Russian Federation
Russian Federation
Gotovtsev Nyurgun Naumovich – Scientific researcher, laboratory of molecular genetics
677000, Sakha Republic, Yakutsk, Yaroslavsky st. 6/3. Phone: 89141062015
N. A. Barashkov
Federal State Budgetary Scientific Institution "Yakut Science Centre of complex medical problems"
Russian Federation
Russian Federation
Barashkov Nikolay Alekseevich – Candidate of biological sciences, Leading Researcher of laboratory of molecular genetics
677000, Sakha Republic, Yakutsk, Yaroslavsky st. 6/3. Phone: 8-(4112) 31-93-94
V. G. Pshennikova
Federal State Budgetary Scientific Institution "Yakut Science Centre of complex medical problems"
Russian Federation
Russian Federation
Pshennikova Vera Gennadievna – Candidate of Biological Sciences, Leading Researcher, Head of laboratory of Populational Genetics
677000, Sakha Republic, Yakutsk, Yaroslavsky st. 6/3. Phone: 8-(4112) 31-93- 94
M. V. Pak
Federal State Autonomous Educational Institution of Higher Education "North-Eastern Federal University M.K. Ammosov"
Russian Federation
Russian Federation
Pak Maria Vladimirovna – postgraduate student of the Medical institute
677013, Sakha Republic, Yakutsk, Oyunskogo st. 27
K. S. Loskutova
Medical institute, Federal State Autonomous Educational Institution of Higher Education "North-Eastern Federal University M.K. Ammosov"
Russian Federation
Russian Federation
Loskutova Kiunnai Savvichna – Candidate of Medical Science, Associate Professor
677013, Sakha Republic, Yakutsk, Oyunskogo st. 27
S. A. Fedorova
Federal State Autonomous Educational Institution of Higher Education "North-Eastern Federal University M.K. Ammosov"
Russian Federation
Russian Federation
Fedorova Sardana Arkadievna – Doctor of biological sciences, Head of the Research Laboratory of Molecular Biology Institute of Natural Sciences
677010, Sakha Republic, Yakutsk, Kulakovsky st. 46
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Review
For citations:
Gotovtsev N.N., Barashkov N.A., Pshennikova V.G., Pak M.V., Loskutova K.S., Fedorova S.A. Prevalence of East Asian (East CagA) and Western variants of the cagA (Western cagA) gene of Helicobacter pylori in Yakutia. Yakut Medical Journal. 2021;(2):63-67. https://doi.org/10.25789/YMJ.2021.74.16
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