Interrelation of the content of transferrin, erythrocytes with the functional activity of leukocytes of peripheral venous blood in residents of the European North of the Russian Federation
https://doi.org/10.25789/YMJ.2021.74.05
Abstract
The relationship between the content of transferrin and erythrocytes and the functional activity of leukocytes of peripheral venous blood in residents of the European North of the Russian Federation have been studied. It was found that in 49.21% of the examined individuals the content of transferrin increases against the background of a decrease in the level of the number of cells with a membrane receptor for transferrin (CD71 +), which reflects the known competing relationships of the receptor, the level of its shedding and substrate (transport). An increase in transferrin content is associated with an increase in the concentration of circulating IgG immune complexes in 44.21% of cases. With an increase in the concentration of transferrin in the blood in 27.95%, the content of platelets decreases and in 24.08% - the concentration of hemoglobin, mainly in men with increasing age. In 8.06% of the examined individuals, an increase in the level of transferrin is interrelated with an increase in the concentration of reagins. In 5.12% of cases, an increase in the transferrin content is associated with the activation of cell-mediated cytotoxicity, which is mainly supported by the pro-inflammatory cytokine IL-6. The relationship between the increase in transport protein and IL-10 concentration has not been established.
Keywords
transferrin,
erythrocytes,
hemoglobin,
lymphocytes,
cytokines,
immunoglobulin E,
circulating immune complexes
Supporting agencies: Work is performed under the program of fundamental scientific research on the topic of the laboratory of regulatory mechanisms in immunity, Institute of physiology of natural adaptations, "the Role of the extracellular pool of adhesion molecules and short peptides in the formation and outcome of adaptive reactions to changing light conditions" (№ AAAA-A17-117033010123-0).
About the Authors
K. O. Pashinskaya
Institute of physiology of natural adaptations at the N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Pashinskaya Ksenia Olegovna – postgraduate student of 2 years of study, junior researcher at the laboratory regulatory mechanisms of immunity
Work phone: (8182) 21-04-58
A. V. Samodova
Institute of physiology of natural adaptations at the N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Samodova Anna Vasilievna – PhD (Biology), Leading Researcher, Head of laboratory regulatory mechanisms of immunity
Work phone: (8182) 21-04-58
L. K. Dobrodeyeva
Institute of physiology of natural adaptations at the N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Dobrodeyeva Lily Konstantinovna – MD, Prof., honored worker of science, Director, Chief Researcher of laboratory regulatory mechanisms of immunity, director
Work phone: (8182) 65-29-92
References
1. Belchenko D.I. The functional system of non-lymphoid cells in the erythrocyte clearance of circulating immune complexes / D.I. Belchenko // Immunology. - 2013. - T. 34. No. 2. – P.88-90.
2. Deryapa N.R. Human adaptation in the polar regions of the Earth / N.R. Deryapa, I.F. Ryabinin. - L .: Medicine. Leningrad. department, - 1977. - 296 p.
3. Dobrodeeva L.K. Interrelationships in the immune system / L.K. Dobrodeeva, A.V. Samodova, O.E. Karyakina. - Yekaterinburg: RIO UrO RAS, 2014. – 200 p.
4. Ermolenko V.M. Physiology of iron metabolism / V.M. Ermolenko, N.N. Filatova // Anemia. - 2004. - No. 1. - P. 3–10.
5. Leonov V.V. Iron and microorganisms / V.V. Leonov, A.Yu. Mironov. Khanty-Mansiysk: LLC "Printing world of Khanty-Mansiysk", 2016. - 178 p.
6. Loginov S.I. Immune complexes of animals and humans: norm and pathology / S.I. Loginov, P.N. Smirnov, A.N. Trunov. - Novosibirsk: IEVS and DV, 1999 .- 143 p.
7. Metabolic immunity / А.М. Zemskov, V.M. Zemskov, V.A. Zemskova [et al.] // Vestnik VSU; Series: Chemistry. Biology. Pharmacy. - 2016. - No. 2. - P. 41‒49.
8. Mechanisms of human adaptation in conditions of high latitudes / V.P. Kaznacheev, V.Yu. Kulikov, L.E. Panin [and others]. - L .: Medicine, 1980. -200 p.
9. Normal hematopoiesis and its regulation / О.К. Gavrilov, I.L. Chertkov, G.I. Kozinets [and others]: ed. acad. N.A. Fedorov. - M .: Publishing house "Medicine", 1976. – 543 p.
10. Pozhivalova E.V., Novikov V.E., Levchenkova O.S. Reactive oxygen species in cell physiology and pathology // Bulletin of the Smolensk State Medical Academy. - 2015; 14(2): 13-21.
11. Participation of transferrin receptors in metabolic processes / L.K. Dobrodeeva, A.V. Samodov, I.S. Zubatkina [et al.] // Russian Allergy Journal. - 2013. - No. 2 (2). - P. 84–85
12. Yarets Yu.I. Specific proteins: a practical guide for doctors: in 2 parts. - Part II. Clinical and diagnostic value of the determination of specific proteins / Yu.I. Yarets. - Gomel, 2015 - 47 p.
13. Alvin H. Schmaier Transferrin: a blood clotting modifier / Schmaier H Alvin // Cell Research. ‒ 2020. ‒ Vol. 30(2) ‒ P. 101‒102.
14. Andrews N.C. Iron homeostasis / N.C. Andrews, P.J. Schmidt // Annual Review of Physiology. ‒ 2007. ‒ N. 69. ‒ P. 69–85.
15. Crichton R. Iron therapy with special emphasis on intravenous administration / R. Crichton, В. Danielson, P. Geisser. ‒ London– Boston: UNI-MED Verlag AG, 2008. ‒ 128 p.
16. De Domenico I. Regulation of iron acquisition and storage: consequences for iron linked disorders / I. De Domenico, D. McVey Ward, J. Kaplan // Nature Reviews Molecular Cell Biology ‒ 2008. ‒ N. 9. ‒ P. 72–81.
17. Demaria S. Soluble beta 2-macroglobulin-free class I heavy chains are reased from that surface of activated and leukemia cells by a metalloprotease / S. Demaria, R. Schwab, S.R. Gottensman, Y. Buskin // Journal of Biological Chemistry. ‒ 1994. – Vol. 269. – P. 6689‒6694.
18. Edison E.S. Iron homeostasis: new players, newer insights / E.S. Edison, A. Bajel, M. Chandy // European Journal of Hematology. ‒ 2008. ‒ N. 81. ‒ P. 411–424.
19. Lawen A. Mammalian iron homeostasis in health and disease: uptake, storage, trans" port and molecular mechanisms of action / A. Lawen, D.J.R. Lane // Antioxidants and Redox Signaling. ‒ 2013. ‒ N. 18. ‒ P. 2473–2507.
20. Мasaki H. The High affinity receptor (FcεRI) mediates IgE-dependent allergen presentation / H. Мasaki, C. Ebner, B. Reininger // The journal of immunology. – 1995. – Vol. 154. – P. 6285–6290.
21. Moura I.C. Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy / I.C. Moura, M.N. Centelles, M. Arcos Fajardo, D.M. Malheiros, Collawn, M.D. Cooper, R.C. Monteiro // The Journal of Experimental Medicine. ‒ 2001. ‒ Vol.194. ‒ P. 417‒425.
22. Shau H. The role transferrin in natural killer cell and IL-2 induced cytotoxic cell function / H. Shau, D. Shen, S.H. Golub // The journal of immunology. – 1986. – Vol. 97. – P. 121‒139.
23. Tang X. Transferrin plays a central role in coagulation balance by interacting with clotting factors / X. Tang, Z. Zhang, M. Fang et al. // Cell Research. ‒ 2020. ‒ Vol. 30. – P. 119‒132.
24. Zhang Qi Uncoupling of CD71 shedding with mitochondrial clearance in reticulocytes in a subset of myelodysplastic syndromes / Qi Zhang, D.P. Steensma, J. Yang, T. Dong, M. X. Wu // Leukemia. ‒ 2019. ‒ Vol. 33(1). – P. 217‒219.
Review
For citations:
Pashinskaya K.O., Samodova A.V., Dobrodeyeva L.K. Interrelation of the content of transferrin, erythrocytes with the functional activity of leukocytes of peripheral venous blood in residents of the European North of the Russian Federation. Yakut Medical Journal. 2021;(2):20-23. https://doi.org/10.25789/YMJ.2021.74.05
Views:
11
Email this article 