Polymorphic marker RS 137100 of the LEPR gene and metabolic disorders in the indigenous population of Yakutia
https://doi.org/10.25789/YMJ.2021.74.01
Abstract
The aim of the study was to search for associations of the rs 1137100 polymorphic marker of the LEPR gene with the lipid spectrum, metabolic syndrome and its components in the indigenous inhabitants of Yakutia. The study involved 227 representatives of the Yakut nationality, permanently residing in the village of Berdigestyah, Gorny region of Yakutia. A statistically significant relationship was established between allelic variant A, AA / AG genotypes of the LEPR gene with hypoalphacholesterolemia. No association with metabolic syndrome or its components was found.
Keywords
Supporting agencies: This study was carried out within the framework of the state assignment of the Ministry of Education and Science of the Russian Federation on the topic “Genome-Wide Studies of the Gene Pool of the Indigenous Population of the Arctic Coast of Yakutia” (State Registration Number FSRG-2020-0017).
About the Authors
E. P. Ammosova
NEFU;
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Ammosova Elena Petrovna - Candidate of Medical Sciences, Leading Researcher, Research Center of the Medical Institute;
Associate Professor of the Department of Pharmacology and Pharmacy
tel.: +79644243908
T. M. Klimova
M.K. Ammosov North-Eastern Federal University;
Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Klimova Tatiana Mikhailovna - Candidate of Medical Sciences, Associate Professor, Department of Pharmacology and Pharmacy, Medical Institute;
Senior Researcher, Department of Epidemiology of Chronic Noncommunicable Diseases
Yakutsk
tel.: +79142336724
R. N. Zakharova
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Zakharova Raisa Nikolaevna - Candidate of Medical Sciences, Leading Researcher, Research Center of the Medical Institute
677000, Yakutsk, 27 Ulitsa Oyunskogo, tel.: +79142223002
A. I. Fedorov
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Fedorov Afanasy Ivanovich - Candidate of Biological Sciences, Senior Scientist, Research Laboratory of Molecular Medicine and Human Genetics of the Medical Institute
677000, Yakutsk, 27 Ulitsa Oyunskogo, tel. +79142332966
M. E. Baltakhinova
Aurora Medical Clinic
Russian Federation
Russian Federation
Baltakhinova Marina Egorovna - General Practitioner
Yakutsk, 20/1 Ulitsa Poyarkova 20/1, tel.: +79142710634
References
1. Gyrgolkau L.A. Content of lipids in blood and frequency of dyslipoproteinemia in the indigenous inhabitants of Chukotka / Gyrgolkau L.A., Shcherbakova L.V., Ivanova M.V. // Bulletin of the Siberian Branch of the Russian Academy of Medical Sciences, 2011 – Tomsk: 31, No. 5 – P. 79–83.
2. Lipid profile and dyslipoproteinemia in the indigenous rural population of Yakutia / Klimova T. M. [et al.] // Siberian Medical Journal (Tomsk) – 2012 – Tomsk: 27 – No. 3 – P. 142-146.
3. Metabolic syndrome among the indigenous female population of Yakutia / T.M. Klimova [et al.] // Yakutsk Medical Journal – 2019 – 3 (25) – P. 66-70.
4. Association between variants of the leptin receptor gene (LEPR) and overweight: a systematic review and an analysis of the CoLaus study / Nicole Bender, Noe¨mi Allemann, Diana Marek et.al/ // PLoS ONE - 2011 - Volume 6 - Issue 10 – P. 1-14 e26157.
5. Association of leptin receptor gene polymorphisms with genetic susceptibility to ischemic stroke / Hui Tang, Zhen Zhang, Zheng-Ke Li [et. al.] // Journal of Stroke and Cerebrovascular Diseases – 2015 - Vol. 24, No. 9 (September) – P. 2128-2133.
6. Association of LEPR K109R polymorphisms with cancer risk: a systematic review and pooled analysis / Hui Shi, Hexi Shu, Changjia Huang [et. al.] // JBUON – 2014 - 19(3) – P 847-854.
7. Common variants of IL6, LEPR, and PBEF1 are associated with obesity in indian children / Rubina Tabassum, Yuvaraj Mahendran, Om Prakash Dwivedi [et.al.] // Diabetes – 2012 - vol. 61, march – P. 625-631.
8. Cytokine re ceptor signal transduction and the control of hematopoietic cell development / Watowich SS, Wu H, Socolovsky M, [et al.] // Annu Rev Cell Dev Biol 1996 – 12 – P. 91–128.
9. Equilibrium Hardy-Weinberg [Online]. [cited 2017 June 15]. Available from: https://wpcalc.com/en/equilibrium-hardy-weinberg/.
10. Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort / Aline dos Santos Rocha, Rita de Cássia Ribeiro-Silva, Gustavo Nunes de Oliveira Costa et. al. // Nutrients – 2018 – 10 –1117 – P. 1-14 doi:10.3390/nu10081117
11. International Diabetes Federation: IDF consensus worldwide definition of the metabolic syndrome [article online], 2006. URL: http://www.idf.org/webdata/docs/IDF_Meta_def_final.pdf (accessed 15 August 2012).
12. Lei Wu. Leptin receptor gene polymorphism and the risk of cardiovascular disease: a systemic review and meta-analysis / Lei Wu, Dali Sun // Int. J. Environ. Res. Public Health – 2017 – 14 - 375; doi:10.3390/ijerph14040375.
13. Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults / Catherine M. Phillips, Louisa Goumidi, Sandrine Bertrais [et. al.]// The Journal of Nutrition – 2010 - 140 – P. 238–244.
14. Metabolic syndrome in Yup’ik Eskimos: the Center for Alaska Native Health Research (CANHR) Study / Boyer B., Mohatt G. V., Plaetke R. [et al.] // Obesity. – 2007 - Vol. 15 - N 11. - P. 2535–2540.
15. Peilin Xiao Associations of leptin and leptin receptor genetic variants with coronary artery disease: a meta-analysis / Peilin Xiao, Jianli Shi, Xiaoli Liu // Bioscience Reports - 2019 -39 BSR20190466 – P.1-7 https://doi.org/10.1042/BSR20190466
16. Polymorphism in leptin receptor gene was associated with obesity in Yogyakarta, Indonesia / Pramudji Hastuti, Izza Zukhrufia, Made Harumi Padwaswari [et. al.] // The Egyptian Journal of Medical Human Genetics - 2016 –17 – P. 271-276.
17. Prevalence of obesity and its metabolic correlates among the circumpolar Inuit in 3 countries / Young M.D., Bjerregaard P., Dewailly E.[ et al.] // Am. J. Publ. Health. – 2007. – Vol. 97 (4). – Р. 691– 695.
18. Seasonal and socioeconomic influences on thyroid function among the Yakut (Sakha) of Eastern Siberia / Stephanie B Levy, William R Leonard, Larissa A Tarskaia [et al.] // American Journal of Human Biology. – 2013. - 25(6). – P. 814-820. DOI: 10.1002/ajhb.22457.
19. Seasonal variation in basal metabolic rates among the Yakut (Sakha) of Northeastern Siberia / Leonard WR, Levy SB, Tarskaia LA [et al.] // American Journal of Human Biology. - 2014. - 26(4). – P. 437-445. DOI: 10.1002/ajhb.22524.
20. The Role of leptin levels in adaptation to cold climates // Alena A. Nikanorova, Nikolay A. Barashkov, Sergey S. Nakhodkin [et. al.] / Int. J. Environ. Res. Public Health - 2020, - 17- 1854; doi:10.3390/ijerph17061854.
21. Valentina Paracchini. Genetics of leptin and obesity: A HuGE Review / Valentina Paracchini, Paola Pedotti, Emanuela Taioli // Am J Epidemiol - 2005 – 162 – P. 101–114.
22. Yunzhong Yang. Meta-analysis of associations of LEPR Q223R and K109R with T2D / Yunzhong Yang, Tianhua Niu / PLOS ONE – 2018 - January 2 – P.1-25 https://doi.org/10.1371/journal.pone.0189366.
Review
For citations:
Ammosova E.P., Klimova T.M., Zakharova R.N., Fedorov A.I., Baltakhinova M.E. Polymorphic marker RS 137100 of the LEPR gene and metabolic disorders in the indigenous population of Yakutia. Yakut Medical Journal. 2021;(2):5-9. https://doi.org/10.25789/YMJ.2021.74.01
Views:
9
Email this article 