5-nucleotidase activity in the placenta in cytomegalovirus infection as a marker of the development of preeclampsia
https://doi.org/10.25789/YMJ.2021.75.23
Abstract
We studied the activity of 5'-nucleotidase in the placenta from women with reactivation of cytomegalovirus (CMV) infection in the third trimester of pregnancy and preeclampsia. An increase in the intensity of the histochemical reaction for 5'-nucleotidase in the villi syncytiotrophoblast was revealed in comparison with the control group (without reactivation), indicating an increase in the enzyme activity. In our opinion, the development of characteristic symptoms of preeclampsia in CMV infection during pregnancy could be facilitated by an increase in 5'-nucleotidase activity, which created a high level of adenosine.
About the Authors
I. V. Dovzhikova
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Dovzhikova Inna Viktorovna - PhD, D.Sc. (Biol.), Leading Staff Scientist of Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases
I. A. Andrievskaya
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Andrievskaya Irina A. - PhD, D.Sc. (Biol.), Professor RAS, Head of Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases
K. K. Petrova
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Petrova Ksenia Konstantinovna - MD, obstetrician-gynecologist
References
1. Gorikov I.N. Changes in the systemic inflammatory response in women in the third trimester of pregnancy complicated by exacerbation of cytomegalovirus infection / I.N. Gorikov // Bulletin physiology and pathology of respiration. – 2020. – Is. 77. – P. 56-62. DOI: 10.36604/1998-5029-2020-77-56-62
2. Dovzhikova I.V. Infringement of hormonogenesis processes in the placenta at the pregnancy complicated by herpetic infection exacerbation / I.V. Dovzhikova // Yakut Medical Journal. – 2009. – №1 (25). – Р. 41-44.
3. Lojda Z., Gossrau R., Schiebler T.H. Enzyme histochemistry: a laboratory manual. – Мoscow: Mir, 1982. – 272 р.
4. Lucenko M.T. Energy metabolism in the placenta and the role of disturbances in the development of placental insufficiency at an exacerbation of cytomegalovirus infection / M.T. Lucenko, I.A.Andrievskaja, I.V. Dovzhikova // Annals of the Russian Academy of Medical Sciences. – 2016. – Vol. 71, №3. – P. 177-182. DOI: 10.15690/vramn534
5. Patent 2620565 of the Russian Federation. A method for determining the formation of a threat of miscarriage of an embryo in the first trimester of gestation under the action of cytomegalovirus infection during an exacerbation on a factor induced by hypoxia / M.T. Lucenko, I.A. Andrievskaja; applicant and patent holder of Federal State Budgetary Scientific Institution "Far Eastern Scientific Center of Physiology and Pathology of Respiration"; declared in 01.08.2016; 26.05.2017, Bul. N. 15.
6. Adenosine and preeclampsia / R. Salsoso, M. Farías, J. Gutiérrez [et al.] // Mol. Aspects Med. – 2017. – Vol. 55. – Р. 126-139. doi: 10.1016/j.mam.2016.12.003.
7. Burnstock G. Purinergic signalling in the reproductive system in health and disease / G. Burnstock // Purinergic Signal. – 2014. – Vol. 10, №1. – Р. 57-87. doi: 10.1007/s11302-013-9399-7.
8. CD39 and CD73 in immunity and inflammation / L. Antonioli, P. Pacher, E.S. Vizi [et al.] // Trends Mol. Med. – 2013. – Vol. 19, №6. – Р. 355-367. doi: 10.1016/j.molmed.2013.03.005.
9. Cytomegalovirus infection and risk of preeclampsia: A metaanalysis of observational studies / Z. Geraili, S.M. Riahi, S. Khani [et al.] // Caspian J. Intern. Med. – 2018. – Vol.9, №3. – Р. 211–219. doi: 10.22088/cjim.9.3.211
10. Cytomegalovirus infection increases the expression and activity of ecto-ATPase (CD39) and ecto-5'nucleotidase (CD73) on endothelial cells / A.M. Kas-Deelen, W.W. Bakker, P. Olinga [et al.] // FEBS Lett. – 2001. – Vol. 491, №1-2. – Р. 21-25. doi: 10.1016/s0014-5793(01)02085-3.
11. Danger signals from ATP and adenosine in pregnancy and preeclampsia / F. Spaans, P. de Vos, W.W. Bakker [et al.] // Hypertension. – 2014. – Vol. 63, №6. – Р. 1154-1160. doi: 10.1161/HYPERTENSIONAHA.114.03240.
12. Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia / T. Iriyama, K. Sun, N.F. Parchim [et al.] // Circu lation. – 2015. – Vol. 131, №8. – Р. 730-741. doi: 10.1161/CIRCULATIONAHA.114.013740.
13. Espinoza J. High fetal plasma adenosine concentration: a role for the fetus in preeclampsia? / J. Espinoza, A.F. Espinoza, G.G. Power // Am. J. Obstet. Gynecol. – 2011. – Vol. 205, № 5. – Р. 485.e24-7. doi: 10.1016/j.ajog.2011.06.034.
14. Fox I.H. Purine catabolism in man: characterization of placental microsomal 5'-nucleotidase / I.H. Fox, P.J. Marchant // Can. J. Biochem. 1976. – Vol. 54, №5. – Р. 462-469. doi: 10.1139/o76-066. PMID: 6135.
15. Human infectious diseases and risk of preeclampsia: an updated reviewof the literature / M. Nourollahpour Shiadeh, Z. Behboodi Moghadam, I. Adam [et al.] // Infection. – 2017. – Vol.45, №5. – Р. 589–600. doi: 10.1007/s15010-017-1031-2
16. Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases expression of the A2A receptor / F. von Versen-Höynck, A. Rajakumar, S.A. Bainbridge [et al.] // Placenta. – 2009. – Vol. 30, №5. – Р. 434-442. doi: 10.1016/j.placenta.2009.02.004.
17. Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming / C. Escudero, J.M. Roberts, L. Myatt [et al.] // Front Pharmacol. – 2014. – Vol. 5. – Р. 134. doi: 10.3389/fphar.2014.00134.
18. Increased plasma adenosine concentrations and the severity of preeclampsia / Y. Yoneyama, S. Suzuki, R. Sawa [et al.] // Obstet. Gynecol. – 2002. – Vol. 100, №6. – Р. 1266-1270. doi: 10.1016/s0029-7844(02)02247-0.
19. Liu H. Beneficial and detrimental role of adenosine signaling in diseases and therapy / H. Liu, Y. Xia // J. Appl. Physiol. (1985). – 2015. – Vol. 119, №10. – Р. 1173-1182. doi: 10.1152/japplphysiol.00350.2015.
20. Maguire M.H. Human placental 5'-nucleotidase: purification and properties / M.H. Maguire, T.P. Krishnakantha, D.M. Aronson // Placenta. – 1984. – Vol. 5, № 1. – P. 21-39. doi: 10.1016/s0143-4004(84)80046-6.
21. Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form / Y. Misumi, S. Ogata, K. Ohkubo [et al.] // Eur. J. Biochem. 1990. – Vol. 191, №3. – Р. 563–569. doi: 10.1111/j.1432-1033.1990.tb19158.x.
22. Soluble tumor necrosis factor receptor 1 is a potential marker of inflammation in the trophoblast associated with cytomegalovirus infection / I.A. Andrievskaya, I.V. Dovzhikova, N.A. Ishutina [et al.] // Am. J. Respir. Care Med. –2019. – Vol. 199. – Р. A6173. doi: 10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A6173
23. Ultracytochemical localizations of adenosine nucleotidase activities in the human term placenta, with special reference to 5′-nucleotidase activity / S. Matsubara, T. Tamada, K. Kurahashi [et al.] // Acta Histochem. Cytochem. – 1987. – Vol. 20. – Р. 409–419.
24. Yegutkin G.G. Adenosine metabolism in the vascular system / G.G. Yegutkin // Biochem. Pharmacol. – 2021. – Vol. 187. – P. 114373. doi: 10.1016/j.bcp.2020.114373.
Review
For citations:
Dovzhikova I.V., Andrievskaya I.A., Petrova K.K. 5-nucleotidase activity in the placenta in cytomegalovirus infection as a marker of the development of preeclampsia. Yakut Medical Journal. 2021;(3):91-94. https://doi.org/10.25789/YMJ.2021.75.23
Views:
9
Email this article 