Cellular and molecular mechanisms of action of neurosteroids in various parts of the central nervous system (Part 2)
https://doi.org/10.25789/YMJ.2021.75.22
Abstract
Neurosteroids (or neuroactive steroids) are a class of endogenous compounds which are synthesized in nervous tissue or\and able to modulate the brain functional activity, the class also includes steroids from gonads or adrenals, which are capable of migrating through the blood brain barrier to achieve their biological targets. The second part of the review is focused on describing multiply features of synthesis, functioning of such neurosteroids as progesterone, allopregnanolone, dehydroepiandrosterone and dehydroepiandrosterone sulfate as well as their targets, synthesized analogs.
About the Authors
D. V. Dmitrenko
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Dmitrenko Diana Viktorovna - Advanced Doctor in Medical Sciences, head of medical genetics and clinical neurophysiology department
S. N. Zobova
Scientific Research Institute of Medical Problems of the North and medical genetics laboratory of V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Zobova Svetlana Nikolaevna - Ph.D. of Medical Sciences, research officer
T. G. Ruksha
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Ruksha Tatyana Gennadievna - Advanced Doctor in Medical Sciences, professor, head of pathophysiology and clinical pathophysiology department
T. I. Prusova
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Prusova Tatyana Igorevna - student, laboratory assistant of medical genetics and clinical neurophysiology department
A. A. Usoltseva
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Usoltseva Anna Alexandrovna - clinical resident, laboratory assistant of medical genetics and clinical neurophysiology department
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Review
For citations:
Dmitrenko D.V., Zobova S.N., Ruksha T.G., Prusova T.I., Usoltseva A.A. Cellular and molecular mechanisms of action of neurosteroids in various parts of the central nervous system (Part 2). Yakut Medical Journal. 2021;(3):85-91. https://doi.org/10.25789/YMJ.2021.75.22
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