Efficiency of homeobox gene expression assessment for predicting outcomes of assisted reproductive technology program
https://doi.org/10.25789/YMJ.2021.75.08
Abstract
An analysis of the effect of HOXA10 and HOXA11 expression in the endometrial stroma of late reproductive women with tubal infertility factor on the outcomes of assisted reproductive technology (ART) programs was performed.
There was a tendency to a statistically significant decrease in the expression of HOXA11 in the endometrial stroma during effective attempts to treat infertility.
Using the ROC (Receiver operator characteristic) method of analysis and calculations of the area under the ROC curve (AUC), it was found out that favorable levels of HOXA11 expression for successful blastocyst implantation and live births in infertile women with their own and donor oocytes.
About the Authors
E. G. Chukhnina
FSBEI HE SUSMU of the Ministry of Health of Russia
Russian Federation
Russian Federation
Chukhnina Elena Galievna – Postgraduate at Department of Pathological Anatomy and Forensic Medicine
Chelyabinsk
E. E. Voropaeva
FSBEI HE SUSMU of the Ministry of Health of Russia
Russian Federation
Russian Federation
Voropaeva Ekaterina Evgenievna – MD, associate professor, professor of the Department of Pathological Anatomy and Forensic Medicine
Chelyabinsk
E. L. Kazachkov
FSBEI HE SUSMU of the Ministry of Health of Russia
Russian Federation
Russian Federation
Kazachkov Evgeny Leonidovich – MD, Professor, Head, Department of Pathological Anatomy and Forensic Medicine
Chelyabinsk
E. A. Kazachkova
FSBEI HE SUSMU of the Ministry of Health of Russia
Russian Federation
Russian Federation
Kazachkova Ella Alekseevna – MD, Professor of the Department of Obstetrics and Gynecology
Chelyabinsk
M. L. Polina
Women's Health Medical Center
Russian Federation
Russian Federation
Polina Miroslava Leonidovna – PhD in Medical Sciences, Gynecologist
Moscow
N. I. Douglas
Medical Institute of North-Eastern Federal University named M.K. Ammosov
Russian Federation
Russian Federation
Douglas Natalya Ivanovna – Grand PhD in Medical Sciences, Head of the Department of Obstetrics and Gynecology
Yakutsk
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Review
For citations:
Chukhnina E.G., Voropaeva E.E., Kazachkov E.L., Kazachkova E.A., Polina M.L., Douglas N.I. Efficiency of homeobox gene expression assessment for predicting outcomes of assisted reproductive technology program. Yakut Medical Journal. 2021;(3):33-37. https://doi.org/10.25789/YMJ.2021.75.08
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