Features of immune responses in autoimmune thyroiditis in residents of the northern region
https://doi.org/10.25789/YMJ.2021.75.07
Abstract
The aim of the study is to identify the features of immune responses in autoimmune thyroiditis (AIT) in inhabitants of the northern region. It was found that with AIT the concentration of cytotoxic T-lymphocytes increases with low activity of natural killer cells and the phagocytic capacity of neutrophilic granulocytes. The development of cell-mediated cytotoxicity is formed at a low background level of activity of mature T-lymphocytes (CD3 +), natural killer cells (CD3 – CD16 + CD56 +), activated T-lymphocytes with a receptor to transferrin (CD71 +) and proliferative lymphocytes (CD10 +).
Keywords
autoimmune thyroiditis,
antibodies,
T-lymphocytes,
pro-inflammatory cytokines,
inhabitants of the North
Supporting agencies: The work was carried out within the framework of the program of fundamental scientific research on the topic of the laboratory of regulatory mechanisms of immunity of the Institute of Physiology of Natural Adaptations "The role of the extracellular pool of adhesion molecules and short peptides in the formation and outcome of human adaptive responses to changes in the light regime" (No. АААА-А17-117033010123-0).
About the Authors
K. V. Vereshchagina
Institute of Physiology of Natural Adaptations of the N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Vereshchagina Ksenia Vitalievna – Senior laboratory assistant, Laboratory of regulatory mechanisms of immunity
A. V. Samodova
Institute of Physiology of Natural Adaptations of the N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Samodova Anna Vasilyevna – candidate of Biological Sciences, Head of the laboratory of regulatory mechanisms of immunity
L. K. Dobrodeeva
Institute of Physiology of Natural Adaptations of the N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Dobrodeeva Liliya Konstantinovna – Doctor of Medical Sciences, Professor, Honored Worker of Science, Chief Researcher of the laboratory of regulatory mechanisms of immunity, Director
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Review
For citations:
Vereshchagina K.V., Samodova A.V., Dobrodeeva L.K. Features of immune responses in autoimmune thyroiditis in residents of the northern region. Yakut Medical Journal. 2021;(3):30-33. https://doi.org/10.25789/YMJ.2021.75.07
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