Search for association of deletion polymorphisms of glutathione-S-transferase GSTM1 and GSTT1 genes with risk of lung cancer in the Yakut population
https://doi.org/10.25789/YMJ.2021.75.06
Abstract
The search for associations of deletion polymorphisms of the enzyme glutathione-Stransferase GSTM1 and GSTT1 with the risk of developing lung cancer in the Yakut population was carried out. The analysis of polymorphic variants of specific regions of genes GSTM1, GSTT1 was carried out in the samples of patients with lung cancer and the control group. In the Yakut population, we did not find a statistically significant relationship between the null genotypes GSTT1 and GSTM1 and their combinations with the risk of developing lung cancer. It was established for the first time that the genotype GSTM1 * + / GSTT1 * 0 in the group of patients with non-small cell lung cancer in the Yakut population was found 3.7 times less frequently than in the control group.
About the Authors
V. M. Nikolaev
Yakut Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Nikolaev Vyacheslav Mikhailovich – Candidate of Biological Sciences, Director
E. K. Rumyantsev
Yakut Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Rumyantsev Egor Konstantinovich – junior researcher
S. I. Sofronova
Yakut Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Sofronova Sargylana Ivanovna – Candidate of Medical Sciences, Director
A. A. Grigorieva
Yakut Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Grigorieva Anastasia Anatolyevna – researcher
S. A. Fedorova
M.K. Ammosov NEFU
Russian Federation
Russian Federation
Fedorova Sardana Arkadyevna – Doctor of Biological Sciences, Head of the scientific research lab
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Review
For citations:
Nikolaev V.M., Rumyantsev E.K., Sofronova S.I., Grigorieva A.A., Fedorova S.A. Search for association of deletion polymorphisms of glutathione-S-transferase GSTM1 and GSTT1 genes with risk of lung cancer in the Yakut population. Yakut Medical Journal. 2021;(3):25-29. https://doi.org/10.25789/YMJ.2021.75.06
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