ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2021.75.06ymj-532Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHПоиск ассоциации делеционных полиморфизмов генов фермента глутатион-S-трансферазы GSTM1 и GSTT1 с риском развития рака легких в популяции якутовSearch for association of deletion polymorphisms of glutathione-S-transferase GSTM1 and GSTT1 genes with risk of lung cancer in the Yakut populationНиколаевВ. М.NikolaevV. M.

Николаев Вячеслав Михайлович – к.б.н., руковод. Отдела

Nikolaev Vyacheslav Mikhailovich – Candidate of Biological Sciences, Director

Nikolaev1126@mail.ruРумянцевЕ. К.RumyantsevE. K.

Румянцев Егор Константинович – м.н.с.

Rumyantsev Egor Konstantinovich – junior researcher

tzeentch1993@mail.ruСофроноваС. И.SofronovaS. I.

Софронова Саргылана Ивановна – к.м.н., руковод. Отдела

Sofronova Sargylana Ivanovna – Candidate of Medical Sciences, Director

sara2208@mail.ruГригорьеваА. А.GrigorievaA. A.

Григорьева Анастасия Анатольевна – н.с.

Grigorieva Anastasia Anatolyevna – researcher

nastiagrigoryeva@gmail.comФедороваС. А.FedorovaS. A.

Федорова Сардаана Аркадьевна – д.б.н., зав. науч.-иссл. лаб.

Fedorova Sardana Arkadyevna – Doctor of Biological Sciences, Head of the scientific research lab

sa.fedorova@s-vfu.ruЯкутский научный центр комплексных медицинских проблемРоссияYakut Scientific Center for Complex Medical ProblemsRussian FederationСВФУ им. М.К. АммосоваРоссияM.K. Ammosov NEFURussian Federation202127042025032529Copyright © Николаев В.М., Румянцев Е.К., Софронова С.И., Григорьева А.А., Федорова С.А., 20252025Николаев В.М., Румянцев Е.К., Софронова С.И., Григорьева А.А., Федорова С.А.Nikolaev V.M., Rumyantsev E.K., Sofronova S.I., Grigorieva A.A., Fedorova S.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/532

Проведен поиск ассоциаций делеционных полиморфизмов фермента глутатион-Sтрансферазы GSTM1 и GSTT1 с риском развития рака легких в популяции якутов. Анализ полиморфных вариантов специфических участков генов GSTM1, GSTT1 был проведен в выборках больных раком легкого и контроля. В популяции якутов нами не было найдено статистически значимой связи между нулевыми генотипами GSTT1 и GSTM1 и их комбинациями с риском развития рака легкого. Впервые установлено, что генотип GSTM1*+/ GSTT1*0 в группе больных немелкоклеточным раком легкого в якутской популяции встречался в 3,7 раза реже по сравнению с группой контроля.

The search for associations of deletion polymorphisms of the enzyme glutathione-Stransferase GSTM1 and GSTT1 with the risk of developing lung cancer in the Yakut population was carried out. The analysis of polymorphic variants of specific regions of genes GSTM1, GSTT1 was carried out in the samples of patients with lung cancer and the control group. In the Yakut population, we did not find a statistically significant relationship between the null genotypes GSTT1 and GSTM1 and their combinations with the risk of developing lung cancer. It was established for the first time that the genotype GSTM1 * + / GSTT1 * 0 in the group of patients with non-small cell lung cancer in the Yakut population was found 3.7 times less frequently than in the control group.

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The authors declare that there are no conflicts of interest present.