Individual differences in the number of mitochondrial DNA copies: the effect of socio-demographic factors
R. F. Enikeeva,
A. V. Kazantseva,
Yu. D. Davydova,
R. N. Mustafin,
M. M. Lobaskova,
S. B. Malykh, 
Y. V. Kovas,
E. K. Khusnutdinova
Y. V. Kovas,
E. K. Khusnutdinova https://doi.org/10.25789/YMJ.2022.78.03
Abstract
Differences in mtDNA copy-number are caused by a complex effect of various environmental factors including chemical, biological or physiological stress, age, and embryonic development. However, to date it remains unknown, which factors and at what age have the most significant impact on mtDNA copy-number and cause greater allostatic load. Therefore, the present study aims to assess the involvement of various socio-demographic parameters in manifesting mtDNA copy-number in healthy individuals aged 18-25 years (N=1065). Within the framework of this study the effects of childhood maltreatment and age on individual differences in mitochondrial DNA copy number were revealed.
About the Authors
R. F. Enikeeva
Institute of Biochemistry and Genetics of Ufa FIT RAS
Russian Federation
Russian Federation
Enikeeva Renata Fanurovna – Candidate of Biological Sciences, researcher
A. V. Kazantseva
Institute of Biochemistry and Genetics of Ufa FIT RAS
Russian Federation
Russian Federation
Kazantseva Anastasia Valeryevna – Candidate of Biological Sciences, senior researcher
Yu. D. Davydova
Institute of Biochemistry and Genetics of Ufa FIT RAS
Russian Federation
Russian Federation
DavydovaA Yulia Dmitrievna – junior researcher
R. N. Mustafin
Bashkir State Medical University
Russian Federation
Russian Federation
Mustafin Rustam Nailevich – Ph.D., Associate Professor
M. M. Lobaskova
Psychological Institute of the Russian Academy of Education
Russian Federation
Russian Federation
Lobaskova Marina Mikhailovna – Candidate of Psychology, senior researcher
S. B. Malykh
Psychological Institute of the Russian Academy of Education
Russian Federation
Russian Federation
Malykh Sergey Borisovich – Doctor of Psychology, professor, Fellow Member of RAE, Head of the lab.
Y. V. Kovas
University of London
United Kingdom
United Kingdom
KOVAS Yulia Vladimirovna – PhD, Professor of Genetics and Psychology, Director of the International Laboratory for Interdisciplinary Studies of Individual Differences in Learning (InLab) at Goldsmith College
Researcher ID (WAS): L7116-2019
Author ID (Scopus): 8680670800
E. K. Khusnutdinova
Institute of Biochemistry and Genetics of the Ufa AIC RAS
Russian Federation
Russian Federation
KhusnutdinovaElsa Kamilevna – Doctor of Biological Sciences, Professor, Corresponding Member of the Russian Academy of Sciences, Director
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Review
For citations:
Enikeeva R.F., Kazantseva A.V., Davydova Yu.D., Mustafin R.N., Lobaskova M.M., Malykh S.B., Kovas Y.V., Khusnutdinova E.K. Individual differences in the number of mitochondrial DNA copies: the effect of socio-demographic factors. Yakut Medical Journal. 2022;(2):13-16. https://doi.org/10.25789/YMJ.2022.78.03
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