Search for factors increasing the risk of developing anxiety and depressive disorders in the Yakut population
https://doi.org/10.25789/YMJ.2024.88.04
Abstract
The survey is devoted to the study of factors increasing the risk of developing anxiety and depressive disorders in the Yakut population. An analysis of anxiety and depression indicators according to the HADS (Hospital Anxiety and Depression Scale) was conducted in a sample of 150 men and 183 women without neurological and mental diseases. It was found that HADS indicators are significantly higher in women compared to men, increased in groups of respondents over 25 years old, in groups of people with disabilities, in married people compared to single people. An analysis of the distribution frequencies of alleles (S and L) and genotypes (SS, SL, LL) of the 5-HTTLPR polymorphism of the SLC6A4 gene was carried out. The results showed a high degree of similarity with the populations of East Asia (Japanese, Chinese, Korean) and significant discrepancies with Caucasian groups. A search for associations of the S and L allele frequencies was conducted in groups with different indicators of anxiety and depression according to the HADS. A statistically significant association of the L allele with subclinical anxiety without depression was revealed.
About the Authors
A. V. Krylov
ФГБНУ «Якутский научный центр комплексных медицинских проблем»
Russian Federation
Russian Federation
N. I. Pavlova
ФГБНУ «Якутский научный центр комплексных медицинских проблем»
Russian Federation
Russian Federation
A. A. Bochurov
ФГБНУ «Якутский научный центр комплексных медицинских проблем»
Russian Federation
Russian Federation
T. Ya. Nikolaeva
ФГАОУ ВО «Северо-Восточный федеральный университет им. М.К. Аммосова»
Russian Federation
Russian Federation
S. K. Kononova
ФГБНУ «Якутский научный центр комплексных медицинских проблем»
Russian Federation
Russian Federation
S. A. Fedorova
ФГАОУ ВО «Северо-Восточный федеральный университет им. М.К. Аммосова», с.н.с. Федерального государственного бюджетного научного учреждения «Якутский научный центр комплексных медицинских проблем»
Russian Federation
Russian Federation
References
1. Study of the 5-HTTLPR polymorphism of the serotonin transporter gene (literature review) / Proshina E.A., Bocharov A.V., Savostyanov A.N., Knyazev G.G. // Journal of Higher Nervous Activ ity named after I.P. Pavlov. 2021. No. 6. P. 803 819
2. Ensembl Genomes [Electronic resource] (access date 31/08/2024) https://www.ensembl.org/Homo_sapiens/Variation/Population?db=core;ph=72542;r=17:30236767-30237841;v=rs774676466;vdb=variation;vf=964026571
3. Distribution of the frequency of intra alleles of the 5-httlpr locus of the serotonin transporter gene in the population of Eurasia and Africa / A.S. Gureev, A.A. Kim, E.D. Sanina, V.I. Shirmanov // Human Ecological Genetics. 2014. No. 3. P. 71 86
4. Russian Society of Psychiatrists. Chapter No. 12. Classification of mental disorders: genобращения etic contribution [Electronic resource] (access date 25/08/24) https://psychiatr.ru/education/slide/418
5. Murakami F, Shimomura T, Kotani K, Ikawa S, et al. Anxiety traits associated with a polymor phism in the serotonin transporter gene regulato ry region in the Japanese. J Hum Genet. 1999; 44 (1): 15-7. DOI: 10.1007/s100380050098
6. Li J, Wang Y, Zhou R, Zhang H, Yang L, et al. Association between polymorphisms in sero tonin transporter gene and attention deficit hyper activity disorder in Chinese Han subjects. Am J Med Genet B Neuropsychiatr Genet. 2007; 144 (1): 14-9. DOI: 10.1002/ajmg.b.30373
7. Katsuragi S, Kunugi H, Sano A, Tsutsumi T, et al. Association between serotonin trans porter gene polymorphism and anxiety-related traits. Biol Psychiatry. 1999; 45 (3): 368-70. DOI: 10.1016/s0006-3223(98)00090-0
8. Choi KW, Kim YK, Jeon HJ. Comorbid Anxiety and Depression: Clinical and Conceptu al Consideration and Transdiagnostic Treatment. Adv Exp Med Biol. 2020; 1191: 219-235. DOI: 10.1007/978-981-32-9705-0_14
9. Bandelow B. Comparison of the DSM-5 and ICD-10: panic and other anxiety disorders. CNS Spectr. 2017; 22 ( 5.): 404-406. DOI: 10.1017/S1092852917000116
10. Savostyanov AN, Bazovkina DV, Lashin SА, et al. Comprehensive analysis of the 5-HTTL PR allelic polymorphism effect on behavioral and neurophysiological indicators of executive control in people from different ethnic groups in Siberia. Zhurnal Genet Selektsii. 2021; 25 (5): 593-602. DOI: 10.18699/VJ21.066
11. Tiller JW. Depression and anxiety. Med J. 2013; 16 (199): 28-31. DOI: 10.5694/mja12.10628
12. Waghorn G, Chant D, et al. Disability, em ployment and work performance among people with ICD-10 anxiety disorders. Aust N Z J Psy chiatry. 2005; 39 (2): 55-66. DOI: 10.1080/j.14401614.2005.01510.x
13. Plomin R, Crabbe J. DNA. Psychol Bull. 2000; 126 (6): 806-828. DOI: 10.1037/0033 2909.126.6.806
14. Duan Z, Lu J. DNA Methyltransferases in Depression: An Update. Front Psychiatry. 2020; 3 (11): 538683. DOI: 10.3389/fpsyt.2020.538683
15. Tewin T, Thapanut S, Sarawut S. Influence of demographic factors and serotonin transport er-linked polymorphic region (5-HTTLPR) vari ants on major depression in a northeastern Thai population. Asian Biomedicine. 2010; 6 (4): 893 899. DOI: https://doi.org/10.2478/adm-2010-0117
16. Caspi A, Sugden K, Moffitt TE, Taylor A, et al. Influence of life stress on depression: moder ation by a polymorphism in the 5-HTT gene. Sci ence. 2003; 301: 5631. P. 386-9. DOI: 10.1126/science.1083968
17. Monroe SM, Harkness KL. Major Depres sion and Its Recurrences: Life Course Matters. Annu Rev Clin Psychol. 2022; 9 (18): 329-357. DOI: 10.1146/annurev-clinpsy-072220-021440
18. Calabro M, Mandelli L, et al. Psychiatric disorders and SLC6A4 gene variants: possible effects on alcohol dependence and alzheimer's disease. Mol Biol Rep. 2020; 47: 191-200. DOI: 10.1007/s11033-019-05119-5
19. Relationship between suicidal behavior of psychotic inpatients and serotonin transporter gene in Han Chinese / Shen Y., Li H., Gu N., Tan Z., [et al.] // Neurosci Lett. 2004. № 30. Vol. 372. P. 94-8. DOI: 10.1016/j.neulet.2004.09.018
20. Licht CL, Mortensen EL, et al. Serotonin transporter gene (SLC6A4) variation and senso ry processing sensitivity-Comparison with other anxiety-related temperamental dimensions. Mol Genet Genomic Med. 2020; 8 (8): 1352. DOI: 10.1002/mgg3.1352
21. Tsai SJ, Hong CJ, Cheng CY. Serotonin transporter genetic polymorphisms and harm avoidance in the Chinese. Psychiatr Genet. 2002; 12 (3): 165-8. DOI: 10.1097/00041444200209000-00008
22. Stein K, Maruf AA, et al. Serotonin Trans porter Genetic Variation and Antidepressant Re sponse and Tolerability: A Systematic Review and Meta-Analysis. J. Pers. Med. 2021; 11: 1334. DOI:https://doi.org/10.3390/jpm11121334
23. Kim SJ, Kang JI, Namkoong K, Song DH. The effects of serotonin transporter promoter and monoamine oxidase A gene polymorphisms on trait emotional intelligence. Neuropsychobiology. 2011; 64 (4): 224-30. DOI: 10.1159/000327705
24. Minelli A, Bonvicini C, Scassellati C, et al. The influence of psychiatric screening in healthy populations selection: a new study and me ta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits. BMC Psychiatry. 2011; 11: 50. DOI: https://doi.org/10.1186/1471-244X-11-50
Review
For citations:
Krylov A.V., Pavlova N.I., Bochurov A.A., Nikolaeva T.Ya., Kononova S.K., Fedorova S.A. Search for factors increasing the risk of developing anxiety and depressive disorders in the Yakut population. Yakut Medical Journal. 2024;(4):16-20. (In Russ.) https://doi.org/10.25789/YMJ.2024.88.04
Views:
183
Email this article 