Study of the antitumor activity of 2-(1,1-dimethyl-1H-benzo[e]indolin-2-yl)-5,6,7-trichloro-1,3-tropolone in combination with temozolomide on the U87 glioblastoma model in vivo
https://doi.org/10.25789/YMJ.2025.89.13
Abstract
This study is aimed to evaluate the antitumor efficacy of 2-(1,1-dimethyl-1H-benzo[e]indolin-2-yl)-5,6,7-trichloro-1,3-tropolone in combination with temozolomide (TMZ) in subcutaneous xenografts of U87 glioblastoma cells in Balb/c Nude mouse line. The findings revealed that combination therapy resulted in a greater reduction in tumor volume and relative tumor mass compared to TMZ monotherapy, with TGI rates of 70.27% versus 66.72%, respectively. Histological analysis confirmed marked cellular dystrophic changes in tumors subjected to combination therapy. These results suggest a potential synergistic interaction between tropolone and temozolomide, which may enhance the efficacy of glioblastoma treatment.
About the Authors
N. S. Kuznetsova
НМИЦ онкологии Минздрава России
Russian Federation
Russian Federation
I. V. Golovinov
НМИЦ онкологии Минздрава России
Russian Federation
Russian Federation
A. S. Goncharova
НМИЦ онкологии Минздрава России
Russian Federation
Russian Federation
A. V. Galina
НМИЦ онкологии Минздрава России
Russian Federation
Russian Federation
S. V. Gurova
НМИЦ онкологии Минздрава России
Russian Federation
Russian Federation
D. V. Khodakova
НМИЦ онкологии Минздрава России
Russian Federation
Russian Federation
A. A. Shulga
НМИЦ онкологии Минздрава России
Russian Federation
Russian Federation
E. E. Rostorguev
НМИЦ онкологии Минздрава России
Russian Federation
Russian Federation
E. A. Gusakov
НИИ ФОХ, Южный федеральн. ун-т
Russian Federation
Russian Federation
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Review
For citations:
Kuznetsova N.S., Golovinov I.V., Goncharova A.S., Galina A.V., Gurova S.V., Khodakova D.V., Shulga A.A., Rostorguev E.E., Gusakov E.A. Study of the antitumor activity of 2-(1,1-dimethyl-1H-benzo[e]indolin-2-yl)-5,6,7-trichloro-1,3-tropolone in combination with temozolomide on the U87 glioblastoma model in vivo. Yakut Medical Journal. 2025;(1):55-59. https://doi.org/10.25789/YMJ.2025.89.13
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