Features of genetic markers of oxidative stress and functional laboratory parameters in comorbid patients with carotid atherosclerosis
https://doi.org/10.25789/YMJ.2025.89.10
Abstract
We studied the characteristics of dependence of the degree of atherosclerotic stenosis of carotid arteries on the level of expression of oxidative stress marker genes in patients with atherosclerosis and comorbid pathology. The association of decreasing the expression of antioxidant protection factors GSTP1, NRF2, HMOX1 with echoscopic features and increasing atherosclerotic stenosis of carotid arteries was identified; inverse correlation between HMOX1 gene expression and right internal carotid artery stenosis degree, between GSTP1 gene expression level and left internal carotid artery stenosis degree; direct correlation between the diameter of the right common carotid artery and the total cholesterol and low serum protein cholesterol levels. The knowledge gained can be used to develop a new medical technology for predicting the progression of atherosclerosis.
About the Authors
V. Ya. Polyakov
ФГБНУ «Федеральный исследовательский центр фундаментальной и трансляционной медицины»
Russian Federation
Russian Federation
Yu. A. Nikolaev
ФГБНУ «Федеральный исследовательский центр фундаментальной и трансляционной медицины»
Russian Federation
Russian Federation
A. V. Gusev
ФГБНУ «Федеральный исследовательский центр фундаментальной и трансляционной медицины»
Russian Federation
Russian Federation
E. V. Sevostyanova
ФГБНУ «Федеральный исследовательский центр фундаментальной и трансляционной медицины»
Russian Federation
Russian Federation
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Review
For citations:
Polyakov V.Ya., Nikolaev Yu.A., Gusev A.V., Sevostyanova E.V. Features of genetic markers of oxidative stress and functional laboratory parameters in comorbid patients with carotid atherosclerosis. Yakut Medical Journal. 2025;(1):39-43. https://doi.org/10.25789/YMJ.2025.89.10
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