Study of coagulation hemostasis in rats under conditions of induced general moderate hypothermia
https://doi.org/10.25789/YMJ.2025.89.07
Abstract
The use of induced hypothermia in clinical practice can lead to coagulopathy, increasing the risk of peri- and postoperative bleeding. The aim of this study was to investigate the effect of cooling the body to moderate hypothermia on the hemostatic system in rats. Activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT) were determined upon reaching a rectal temperature of 32°C and after prolonged two-hour hypothermia while maintaining the animal’s temperature at the same level. It was shown that cooling the animals to moderate hypothermia resulted in an increase in activated partial thromboplastin time, thrombin time, and prothrombin time, indicating the development of hypocoagulation shifts and impairment of the secondary hemostasis. With prolonged hypothermic exposure, a decrease in APTT, TT, and PT parameters from the achieved values was observed, which probably indicates some suppression of coagulation reactions with prolonged exposure to moderate hypothermia. It is suggested that impaired thrombin generation may be a key factor in hypothermia-induced coagulopathy.
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For citations:
Melnikova N.N. Study of coagulation hemostasis in rats under conditions of induced general moderate hypothermia. Yakut Medical Journal. 2025;(1):27-31. https://doi.org/10.25789/YMJ.2025.89.07
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