Относительная длина теломерных повторов у лиц с хроническим алкоголизмом в зависимости от клинико-анамнестических характеристик

Целью настоящего исследования являлась проверка гипотезы об ассоциации более короткой относительной длины теломерных повторов (ОДТП) с манифестацией хронического алкоголизма с учетом клинико-анамнестических характеристик. Был обнаружен статистически значимый эффект возраста в общей группе лиц с алкогольной зависимостью и отдельно среди мужчин на вариации ОДТП. Из изученных клинико-анамнестических характеристик возраст манифестации абстинентного синдрома был негативно связан с ОДТП.

1. Анализ полиморфизма генов дофаминергической системы у больных алкоголизмом, якутов и чукчей по этнической принадлежности / Фасхутдинова Г.Г., Куличкин С.С., Матвеева Н.П. [и др.] // Медицинская генетика. 2008;7(4):1-9. Analysis of dopaminergic system genes in patients with alcoholism from Yakut and Chukchi population / Faskhutdinova G.G., Kulichkin S.S., Matveeva N.P. [et al.] // Medical genetics. 2008;7(4):1-9.

2. Арзуманов Ю.Л., Кибитов А.О. Нейрофизиологические и генетические механизмы предрасположенности к наркологическим заболеваниям. –М.: Национальн. медицин. исслед. центр психиатрии и наркологии им. В.П. Сербского, 2021. - 146 с. Arzumanov Y.L., Kibitov A.O. Neurophysiological and genetic mechanisms of liability to drug diseases. - Moscow: V.P. Serbsky National Medical Research Center of Psychiatry and Narcology, 2021. - 146 p.

3. An Integrative Review of Factors Associated with Telomere Length and Implications for Biobehavioral Research / Starkweather A.R., Alhaeeri A.A., Montpetit A. [et al.] // Nursing research. 2014;63(1):36–50. doi: 10.1097/NNR.0000000000000009

4. An Optimised Step-by-Step Protocol for Measuring Relative Telomere Length / Joglekar M.V., Satoor S.N., Wong W.K.M. [et al.] // Methods Protoc. 2020;3(2):27. doi: 10.3390/mps3020027.

5. Analysis of telomere length variation and Shelterin complex subunit gene expression changes in ethanol-exposed human embryonic stem cells / Moazzam M., Yim T., Kumaresan V. [et al.] // J. Psychiatr. Res. 2021;143:543-549. doi: 10.1016/j.jpsychires.2020.11.027.

6. Association between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Businessmen Study / Strandberg T.E., Strandberg A.Y., Saijonmaa O. [et al.] // Eur. J. Epidemiol. 2012;27(10):815-22. doi: 10.1007/s10654-012-9728-0.

7. Epigenetics of aggressive behavior // Mustafin R.N., Kazantseva A.V., Enikeeva R.F. [et al.] // Russian Journal of Genetics. 2019;55(9):1051- 1060. doi: 10.1134/S1022795419090096

8. Epigenome-wide association study of CpG methylation in aggressive behavior / Borinskaya S.A., Rubanovich A.V., Yankovsky N.K. [et al.] // Russian Journal of Genetics. 2021; 57(12): 1454- 1460. doi: 10.1134/S1022795421120048

9. Genetic predisposition to advanced biological ageing increases risk for childhood-onset recurrent major depressive disorder in a large UK sample / Michalek J.E., Kepa A., Vincent J. [et al.] // J. Affect. Disord. 2017;213:207-213. doi: 10.1016/j.jad.2017.01.017

10. Individual differences in relative telomere length in mentally healthy subjects: the effect of TERT gene polymorphism and urban residency / Kazantseva A.V., Davydova Y.D., Enikeeva R.F. [et al.] Russian Journal of Genetics. 2022;58(9):1074-1084.

11. Leukocyte telomere length is not shortened in methamphetamine dependence or methamphetamine-induced psychosis but is increased following traumatic events / Rungnirundorn T., Krusong K., Kalayasiri R., Maes M. // World J. Biol. Psychiatry. 2022:1-9. doi: 10.1080/15622975.2021.2016957.

12. Measures of possible allostatic load in comorbid cocaine and alcohol use disorder: Brain white matter integrity, telomere length, and anti-saccade performance / Tannous J., Mwangi B., Hasan K.M. [et al.] // PLoS One. 2019;14(1):e0199729. doi: 10.1371/journal.pone.0199729.

13. Modifiable traits, healthy behaviours, and leukocyte telomere length: a population-based study in UK Biobank / Bountziouka V., Musicha C., Allara E. [et al.] // Lancet Healthy Longev. 2022;3(5):e321-e331. doi: 10.1016/S2666-7568(22)00072-1.

14. Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction / Karlsson Linnér R., Mallard T.T., Barr P.B. [et al.] // Nat. Neurosci. 2021;24(10):1367-1376. doi: 10.1038/s41593-021-00908-3.

15. Shin C., Baik I. Associations Between Alcohol Consumption and Leukocyte Telomere Length Modified by a Common Polymorphism of ALDH2 // Alcohol. Clin. Exp. Res. 2016;40(4):765-71. doi: 10.1111/acer.13005.

16. Shortened telomeres in individuals with abuse in alcohol consumption / Pavanello S., Hoxha M., Dioni L. [et al.] // Int. J. Cancer. 2011;129(4):983-92. doi: 10.1002/ijc.25999.

17. The association study of polymorphic variants of hypothalamic-pituitary-adrenal system genes (AVPR1B, OXTR) and aggressive behavior manifestation: a focus on social environment / Kazantseva A.V., Davydova Y.D., Enikeeva R.F. [et al.] // Research Results in Biomedicine. 2021;7(3):232-244. doi: 10.18413/2658-6533-2021-7-3-0-3

18. The effect of ethanol on telomere dynamics and regulation in human cells / Harpaz T., Abumock H., Beery E. [et al.] // Cells. 2018;7(10):169. doi: 10.3390/cells7100169.

19. The role of oxytocin receptor (OXTR) gene polymorphisms in the development of aggressive behavior in healthy individuals / Davydova Y.D., Kazantseva A.V., Enikeeva R.F. [et al.] // Russian Journal of Genetics. 2020;56(9):1129- 1138. doi: 10.1134/S1022795420090057

20. Weischer M., Bojesen S.E., Nordestgaard B.G. Telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake: 4,576 general population individuals with repeat measurements 10 years apart // PLoS Genet. 2014;10(3):e1004191. doi: 10.1371/journal.pgen.1004191.