Sleep structure in adults with recurrent epileptic seizures of remote symptomatic etiology
O. V. Grebenyuk,
T. V. Kazennykh,
M. V. Svetlik,
N. V. Pugachenko,
V. A. Avkhimenko,
A. N. Levko,
V. M. Alifirova,
N. A. Bohan https://doi.org/10.25789/YMJ.2024.85.04
Abstract
A video-polysomnographic study of the structural characteristics of night sleep was carried out in 157 patients with a first-time unprovoked tonic-clonic seizure. The main group included patients with remote symptomatic seizure (RSS). Over the course of three years, 60 individuals had recurrent attacks; 38 patients had no recurrence of attacks during the observation period. The comparison group included 59 MRI- and EEG-negative patients. Patients with recurrent RSS had lower sleep efficiency, longer rapid eye movement phase, sleep fragmentation, wake after sleep onset, and more frequent awakenings from sleep (number of awakenings) versus patients with a single RSS and the comparison group. The identified changes demonstrate deeper disturbances in sleep architecture in patients with recurrent RSS and can be taken into account in prognostic counseling of this category of patients.
Supporting agencies: The article was published as part of the complex research topic “Biopsycho- social mechanisms of pathogenesis and clinical polymorphism, adaptive potential and predictors of treatment effectiveness in patients with mental and behavioral disorders in the Siberian region”, state registration number 122020200054-8, topic code FGWM-2022-0025.
About the Authors
O. V. Grebenyuk
Federal State Budgetary Educational Institution of Higher Professional Education “Siberian State Medical University” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
GREBENYUK Oleg V. – PhD, Associate Professor of the Department of Neurology and Neurosurgery
T. V. Kazennykh
Institute of Tomsk National Research Medical Center
Russian Federation
Russian Federation
KAZENNYKH Tatiana V. – MD, Deputy Director for Scientific and Medical Work of Mental Health Research, Professor of the Department of Psychiatry, Narcology and Psychotherapy of the Federal State Budgetary Educational Institution of Higher Professional Education Siberian State Medical University MH RF
M. V. Svetlik
Biological Institute of the Federal State Autonomous Educational Institution of Higher Education National Research Tomsk State University
Russian Federation
Russian Federation
SVETLIK Mikhail V. – PhD, Associate Professor of the Department of Human and Animal Physiology
N. V. Pugachenko
Federal State Budgetary Educational Institution of Higher Professional Education Siberian State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
PUGACHENKO Natalia V. – Associate Professor of the Department of Neurology and Neurosurgery, Cand.Sc. (Medicine)
V. A. Avkhimenko
Federal State Budgetary Institution of the Siberian Federal Scientific and Clinical Center of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
AVKHIMENKO Viktor A. – PhD, General Director
A. N. Levko
Federal State Budgetary Educational Institution of Higher Professional Education Siberian State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
LEVKO Alena N. – PhD, Vice-Rector for Interaction with Regions
V. M. Alifirova
Federal State Budgetary Educational Institution of Higher Professional Education Siberian State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
ALIFIROVA Valentina M. – MD, Head of the Department of Neurology and Neurosurgery, Professor
N. A. Bohan
Federal State Budgetary Educational Institution of Higher Professional Education Siberian State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
BOKHAN Nikolay A. – MD, Director of Mental Health Research Institute of Tomsk National Research Medical Center, psychiatrist of the highest category, Professor, academician of the Russian Academy of Sciences, Honored Scientist of the Russian Federation, Head of the Department of Psychiatry, Narcology and Psychotherapy
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Review
For citations:
Grebenyuk O.V., Kazennykh T.V., Svetlik M.V., Pugachenko N.V., Avkhimenko V.A., Levko A.N., Alifirova V.M., Bohan N.A. Sleep structure in adults with recurrent epileptic seizures of remote symptomatic etiology. Yakut Medical Journal. 2024;(1):16-20. https://doi.org/10.25789/YMJ.2024.85.04
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