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Difficulties in diagnosing Parkinson's disease with dementia and dementia with Lewy bodies in clinical practice

https://doi.org/10.25789/YMJ.2022.80.34

Abstract

Dementia is a chronic cognitive decline affecting all domains of cognition with an unfavorable outcome, observed in both dementia with Lewy bodies (DLB) and Parkinson's disease (PD). These two conditions belong to the group of alpha-synucleinopathies. In DLB and PD, attention, goal-directed activity, visual-spatial orientation, visual-constructive ability, and memory are affected. The similarity of the profile of cognitive impairment in PD with dementia and DTL leads to some difficulties in the diagnosing of these two diseases. Using their own observations, the authors have demonstrated that an important aspect in making the correct diagnosis is objective information from relatives and analysis of the available medical records.

About the Authors

Yu. I. Khabarova
Yakut Science Centre of Complex Medical Problems
Russian Federation

 Khabarova Yulia Ilyinichna – junior researcher, chief manager of the department of the Neurodegenerative Centre 



A. A. Tappakhov
Yakut Science Centre of Complex Medical Problems; M.K. Ammosov North-Eastern Federal University
Russian Federation

Tappakhov Alexey Alekseevich – Ph.D. and Associate Professor of the Medical Institute of M.K. Ammosov NEFU, senior researcher of thr Neurodegenerative Center YSC CMP



T. E. Popova
Yakut Science Centre of Complex Medical Problems
Russian Federation

Popova Tatyana Egorovna – MD, deputy director for science of YSC CMP



References

1. Golubev V.L. Atipichnyj parkinsonizm [Atypical parkinsonism]. Medicinskij sovet [Medical Council. 2015; 10: 45-49 (In Russ).].

2. Levin O.S., Vasenina E.E., Chimagomedova A.Sh., Dudchenko N.G. Demenciya s tel'cami Levi [[Dementia with Lewy bodies]. Obozrenie psihiatrii i medicinskoj psihologii [Review of Psychiatry and Medical Psychology. 2018; 2: 11-21 (in Russ).]. DOI:10.31363/2313-7053-2018-2-1121

3. Vereyutina I.A., Illarioshkin S.N., Zhuravleva E.Y., Shikhkerimov R.K. Nejropsihologicheskie rasstrojstva na rannej stadii bolezni Parkinsona [Neuropsychological disorders in the early stages of Parkinson’s disease]. Annaly klinicheskoj i eksperimental'noj nevrologii [Annals of clinical and experimental neurology. 2012; 6(2): 11-15 (in Russ).].

4. Nodel M.R., Yakhno N.N. Nervno-psihicheskie narusheniya pri bolezni Parkinsona [Neuropsychiatric disorders in Parkinson's disease]. Nevrologiya, nejropsihiatriya, psihosomatika [Neurology, neuropsychiatry, psychosomatics. 2009; 2: 3-8 (In Russ).].

5. McKeith I.G., Boeve B.F., Dickson D.W. [et. al.] Diagnosis and management of dementia with Lewy bodies. Neurology. 2017; 89 (1): 88-100. DOI:10.1212/WNL.0000000000004058

6. Jellinger K.A., Korczyn A.D. Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease? BMC Med. 2018; 16(1): 1-16. DOI:10.1186/s12916-018-1016-8

7. Poewe W., Seppi K., Tanner C.M. [et al.] Parkinson’s disease. Nat Rev Dis Prim. 2017;ARTICLE NUMBER 17013. DOI:10.1038/nrdp.2017.13

8. Braak H., Ghebremedhin E., Rüb U. [et al.] Stages in the development of Parkinson’s disease-related pathology. Cell Tissue Res. 2004; 318: 121-134. DOI:10.1007/s00441-004-0956-9

9. Tsuboi Y., Dickson D.W. Dementia with Lewy bodies and Parkinson’s disease with dementia: are they different? Parkinsonism Relat Disord. 2005; 11 (1): 47– 51. DOI:10.1016/j.parkreldis.2004.10.014

10. Vasconcellos L.F.R., Pereira J.A. Parkinson’s disease dementia: Diagnostic criteria and risk factor review. J Clin Exp Neuropsychol. 2015; 37 (9): 988-993. DOI:10.1080/13803395.2015.1073227

11. Walker L, Stefanis L., Attems J. Clinical and neuropathological differences between Parkinson’s disease, Parkinson’s disease dementia and dementia with Lewy bodies – current issues and future directions. J. Neurochem. 2019; 150(5): 467-474. DOI:10.1111/jnc.14698


Review

For citations:


Khabarova Yu.I., Tappakhov A.A., Popova T.E. Difficulties in diagnosing Parkinson's disease with dementia and dementia with Lewy bodies in clinical practice. Yakut Medical Journal. 2022;(4):129-132. https://doi.org/10.25789/YMJ.2022.80.34

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ISSN 1813-1905 (Print)
ISSN 2312-1017 (Online)