Some criteria for damage to the cardiovascular system of newborns due to intrauterine hypoxia
https://doi.org/10.25789/YMJ.2023.84.08
Abstract
The results of laboratory and instrumental diagnostic methods in newborns with a history of intrauterine hypoxia were analyzed. Electrocardiographic features were revealed in the form of prolongation of the QT interval; diffuse secondary metabolic-hypoxic changes in the myocardium, such as myocardial hypertrophy, increased myocardial biopotentials from the right and left ventricles; severe overload of both atria. An important role in assessing the state of the cardiovascular system is assigned to the determination of markers for assessing the severity of damage: such as malondialdehyde (MDA) and brain natriuretic peptide (BNP) in the blood serum. As a result of the study, a significantly higher (1.2 times) MDA level was determined in newborns with antenatal hypoxia with NT-proBNP values 4 times higher than the reference laboratory values for the reagent kit. The results obtained suggest the importance of further research into the role of antenatal hypoxia in assessing the state of the cardiovascular system of children.
About the Authors
O. A. Senkevich
Far Eastern State Medical University
Russian Federation
Russian Federation
Senkevich Olga Aleksandrovna – Professor, Head of the department of pediatrics, neonatology and perinatology with a course of emergency medicine
Z. A. Plotonenko
Far Eastern State Medical University
Russian Federation
Russian Federation
Plotonenko Zinaida Anatolyevna – associate professor, the department of pediatrics, neonatology and perinatology with a course of emergency medicine
V. P. Molochny
Far Eastern State Medical University
Russian Federation
Russian Federation
Molochny Vladimir Petrovich – Professor, the Department of Outpatient Pediatrics with a course in childhood infectious diseases
M. N. Pertsev
Far Eastern State Medical University
Russian Federation
Russian Federation
Pertsev Mikhail Nikolaevich – assistant, the department of pediatrics, neonatology and perinatology with a course of emergency medicine
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Review
For citations:
Senkevich O.A., Plotonenko Z.A., Molochny V.P., Pertsev M.N. Some criteria for damage to the cardiovascular system of newborns due to intrauterine hypoxia. Yakut Medical Journal. 2023;(4):32-35. https://doi.org/10.25789/YMJ.2023.84.08
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