Polymorphism rs1127327 of the microRNA-146A target gene CCDC6 associated with a reduced risk of severe hemorrhagic fever with renal syndrome in patients from the Volga-Ural region of Russia
I. R. Gilyazova,
E. A. Ivanova,
A. N. Khasanova,
G. M. Khasanova,
A. A. Izmailov,
R. Ya. Safikhanov,
I. F. Gareev,
O. A. Beylerli,
D. A. Valishin,
R. F. Khusnarizanova,
S. Sh. Galimova,
Guoqing Wang,
Honglan Huang,
Jiahui Pan,
Tong Shao,
Haochen Haochen,
Wenfang Wang,
V. N. Pavlov,
E. K. Khusnutdinova https://doi.org/10.25789/YMJ.2022.78.01
Abstract
The association analysis of polymorphic variants common for miRNA-146a, miRNA-218, miRNA-410, miRNA-503 target genes was performed in patients with hemorrhagic fever infected with PUUV. It has been revealed that the genotype rs1127327*AA of the CCDC6 gene is associated with a reduced risk of severe disease form. Further studies of the network of genes that are targets of various miRNAs are needed to elucidate the molecular mechanisms that can influence the onset and development of HFRS.
Supporting agencies: The study was carried out with the financial support of the Russian Foundation for Basic Research and the State Foundation for Basic Research in the framework of scientific project № 21- 515-53017
About the Authors
I. R. Gilyazova
IBG UFIC RAS; Bashkir State
Medical University
Gilyazova Irina R. – Candidate of Biological Sciences, senior researcher, Laboratory of Human Molecular Genetics; Associate Professor, Department of Medical Genetics and Fundamental Medicine
Ufa
E. A. Ivanova
DNA Institute of the UB RAS
Russian Federation
Russian Federation
Ivanova Elizaveta A. – Candidate of Biological Sciences, researcher, Laboratory of Molecular Genetics of Human
Ufa
A. N. Khasanova
Bashkir State Medical University
Russian Federation
Russian Federation
Khasanova Aliya N. – assistant of the Infectious Diseases Department
Ufa
G. M. Khasanova
Bashkir State Medical University
Russian Federation
Russian Federation
Khasanova Guzel M. –Doctor of Medicine, Professor of the Chair of Infectious Diseases
Ufa
A. A. Izmailov
Bashkir State Medical University
Russian Federation
Russian Federation
Izmailov Adel A. – Doctor of Medical Sciences, Professor of the Department of Urology
Ufa
R. Ya. Safikhanov
Bashkir State University
Russian Federation
Russian Federation
Safikhanov Rishat Ya. – Candidate of Biological Sciences, associate professor of the Department of Zoology
Ufa
I. F. Gareev
Bashkir State Medical University
Russian Federation
Russian Federation
Gareev Ilgiz F. – Ph.D, Candidate of Medical Sciences, Assistant of the Department of Oncology with the courses of oncology and pathological anatomy of the Institute of Advanced Professional Education
Ufa
O. A. Beylerli
ФГБОУ ВО "Башкирский ГМУ" Минздрава России
Russian Federation
Russian Federation
Beylerli Ozal A. – Ph.D.: Candidate of Medical Sciences, Assistant of the Department of Oncology with courses of oncology and pathological anatomy
Ufa
D. A. Valishin
Bashkir State Medical University
Russian Federation
Russian Federation
Valishin Damir A. – Doctor of Medical Sciences/Professor, Head of Infectious Diseases Department
Ufa
R. F. Khusnarizanova
ФГБОУ ВО "Башкирский ГМУ" Минздрава России
Russian Federation
Russian Federation
Khusnarizanova Rauza F. – Ph.D, Candidate of Medical Sciences, Associate Professor of the Department of Microbiology, Virology and Immunology
Ufa
S. Sh. Galimova
Bashkir State Medical University
Russian Federation
Russian Federation
Galimova Saida Sh. – Assistant of the Department of Therapy and Nursing with Nursing
Ufa
Guoqing Wang
Jilin University
China
China
WANG Guoqing – Ph. D., Professor
Changchun, Jilin Province
Honglan Huang
Jilin University
China
China
HUANG Honglan – Ph.D., Professor
Changchun, Jilin
Jiahui Pan
Jilin University
China
China
Pan Jiahui
Changchun, Jilin
Tong Shao
Jilin University
China
China
Shao Tong – Ph. D.
Changchun, Jilin
Haochen Haochen
Jilin University
China
China
Haochen Haochen Yao - Ph.D.
Changchun, Jilin Province
Wenfang Wang
Jilin University
China
China
WANG Wenfang
Changchun, Jilin Province
V. N. Pavlov
ФГБОУ ВО "Башкирский ГМУ" Минздрава России
Russian Federation
Russian Federation
E. K. Khusnutdinova
Институт биохимии и генетики УФИЦ РАН
Russian Federation
Russian Federation
Ufa
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Review
For citations:
Gilyazova I.R., Ivanova E.A., Khasanova A.N., Khasanova G.M., Izmailov A.A., Safikhanov R.Ya., Gareev I.F., Beylerli O.A., Valishin D.A., Khusnarizanova R.F., Galimova S.Sh., Wang G., Huang H., Pan J., Shao T., Haochen H., Wang W., Pavlov V.N., Khusnutdinova E.K. Polymorphism rs1127327 of the microRNA-146A target gene CCDC6 associated with a reduced risk of severe hemorrhagic fever with renal syndrome in patients from the Volga-Ural region of Russia. Yakut Medical Journal. 2022;(2):5-8. https://doi.org/10.25789/YMJ.2022.78.01
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