Features of cellular and humoral immune reactions in the inhabitants of the European North and the Arctic

The features of cellular and humoral immune responses in the inhabitants of the European North and the Arctic have been studied. It has been established that a parallel increase in the frequency of registration of erythrocytosis, thrombocytosis, elevated hemoglobin, hematocrit and thrombocrit in residents of the Murmansk region is a mechanism for adaptation to an increased need for O₂ in the Arctic. The examined individuals showed a high frequency of registration of leukocytosis, lymphocytosis, neutrophilia, monocytosis, eosinophilia and basophilia against the background of a significant level of deficiency of active phagocytes. A feature of the immunological reactivity of the inhabitants of the polar village is the predominance of reactions of cell-mediated and antibody-dependent cytotoxicity against the background of an increase in pro-inflammatory cytokines IL-6, IFN-γ, reagins, intercellular adhesion molecules sCD54 and sCD62L.

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