Comparison of pathological variants of LEPR, FADS1, FADS2 and FABP2 genes in the population of the Republic of Sakha (Yakutia)

This study is devoted to studying the frequencies of pathological gene variants (LEPR, FADS1, FADS2, FABP2) in Yakuts, Russians, and Evenks, as well as their relationship to body mass index (BMI). The study included 776 volunteers from the Republic of Sakha (Yakutia): There are 211 Russians, 140 Evenks and 425 Yakuts. The participants had no chronic diseases. Based on body mass index (BMI), participants were divided into three groups: normal BMI (18.5–24.9 kg/m2), pre-obese (25-29.9 kg/m2) and obese (≥30 kg/m2). The study of polymorphisms rs174537 of the enhancer genes FADS1, FADS2, rs1137101 of the LEPR gene and rs1799883 of the FABP2 gene in populations of Russians (n=211), Evenks (n=140) and Yakuts (n=425) revealed significant population-specific differences.

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