Сравнение вариантов генов LEPR, FADS1, FADS2 и FABP2 у населения Республики Саха (Якутия) с учетом индекса массы тела

Данное исследование посвящено изучению частот вариантов генов (LEPR, FADS1, FADS2, FABP2) у якутов, русских и эвенков, а также их связи с индексом массы тела (ИМТ). В исследование включены 776 добровольцев из Республики Саха (Якутия): 211 русских, 140 эвенков и 425 якутов. Участники не имели хронических заболеваний. По ИМТ участники были разделены на три группы: нормальный ИМТ (18,5–24,9 кг/м²), предожирение (25–29,9 кг/м²) и ожирение (≥30 кг/м²). Исследование вариантов rs174537 энхансера генов FADS1, FADS2, rs1137101 гена LEPR и rs1799883 гена FABP2 в популяциях русских (n=211), эвенков (n=140) и якутов (n=425) выявило значимые популяционно-специфические различия.

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