Preview

Yakut Medical Journal

Advanced search

Organ-sparing treatment for early-stage endometrial cancer with reproductive function

https://doi.org/10.25789/YMJ.2023.82.32

Abstract

   The article presents a clinical case of successful implementation of generative function af-ter a favorable outcome of endometrial cancer treatment. A 41-year-old patient with a diagnosis of endometrioid adenocarcinoma, low ovarian reserve, unrealized reproductive potential was of-fered a variant of organ-preserving treatment in the amount of hysteroresectoscopy followed by hormone therapy. After the treatment, no data on recurrence or progression were revealed at the follow-up examination, pregnancy planning with the help of assisted reproductive technologies was recommended, which was not carried out due to spontaneous pregnancy. This clinical case demonstrated that organ-preserving treatment for early endometrial cancer allowed not only to cure the malignant process, but also subsequently perform a generative function without reducing the effectiveness of treatment.

About the Authors

E. N. Kirillova
Yakut Republican Oncological Dispensary
Russian Federation

Yakutsk



T. I. Nikolaeva
Yakut Republican Oncological Dispensary; Medical Institute of the North-Eastern Federal District M.K. Ammosov University
Russian Federation

Yakutsk



S. A. Myreeva
Yakut Republican Oncological Dispensary
Russian Federation

Yakutsk



T. A. Sosina
Yakut Republican Oncological Dispensary
Russian Federation

Yakutsk



References

1. Association of Oncologists of Russia. Clinical Guidelines. Cancer of the Body of the Uterus. Approved in 2020 (reviewed every 3 years) http://oncology-association.ru/files/clinical-guidelines_adults/rak-tela-matki.pdf

2. Ashrafyan L. A., Kiselev V. I. Tumors of the Reproductive Organs (Etiology and Pathogenesis). Moscow, 2008, pp. 6-11

3. Malignant tumors in Russia in 2021 (incidence and mortality). Ed. by A.D. Kaprin, V.V. Starinskiy, A.O. Shakhzadova. Moscow, 2022.

4. Kaprin A.D., Starinsky V.V., Petrova G.V., Ed. State of Oncological Care for the Population of Russia in 2017. Moscow, 2018. 234 p.

5. Novikova E.G., Chulkova O.V., Pronin S.M. Precancer and Primary Endometrial Cancer in Women of Reproductive Age. Moscow: MIA, 2005. 132 p.

6. Treatment of Relapses of Atypical Hyperplasia and Initial Endometrial Cancer After Self-Hormone Therapy / Novikova O.V., Novikova E.G., Volchenko N.N., et al. Obstetrics and Gynecology: News, Opinions, Training, 2018, 1:68–76.

7. RUSSCO Practical Guidelines for Drug Treatment of Uterine Cancer and Uterine Sarcomas, Version 2022 / Nechushkina V.M., Kolomiets L.A., Kravets O.A., Morkhov K.Y., Novikova E.G., Novikova O.V. et al. doi: 10.18027/2224–5057–2022–12–3s2–260–275 https://rosoncoweb.ru/standarts/RUSS-CO/2022/recoms2022_12.pdf

8. Pronin S.M., Novikova O.V., Andreeva Y.Y. Use of Releasing Systems and Gonadotropin-Releasing Hormone Agonists in the Treatment of Atypical Hyperplasia and Early Endometrial Cancer. Oncology. P. Herzen Journal. 2013; 1:40-3.

9. Alteri D.C. Survivin versatile modulation of cell division and apoptosis in cancer // Oncogene. 2003. Vol. 22. 858-16.

10. Carneiro M.M., Lamaita R.M., Ferreira M.C.F., Silva-Filho A.L. Fertility-preservation in endometrial cancer: is it safe? Review of the literature. JBRA Assist Reprod. 2016; 20(4): 232-9. doi: 10.5935/1518-0557.20160045

11. Colombo N., Creutzberg C., Amant F. ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up. Ann Oncol. 2016; 27(1): 16-41. doi: 10.1093/annonc/mdv484.

12. De Felice F., Marchetti C., Di Pinto A., Musella A., Palaia I., Grazia Porpora M., et al. Fertility preservation in gynaecologic cancers. Ecancermedicalscience. 2018; 12: 798. doi: 10.3332/ecancer.2018.798.

13. Endometrial cancer in women 40 years old or younger. Duska L.R., Garrett A., Rueda B.R., Haas J., Chang Y., Fuller A.F. Gynecol Oncol. 2001; 83(2):388–393.

14. ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: Colombo N., Creutzberg C., Amant F. et al. Diagnosis, treatment and follow-up. Ann Oncol. 2016;27:16–41.

15. Ferlay J., Soerjomataram I., Dikshit R. et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 // Int. J. Cancer. 2015. Vol. 136 (5). P. E359–E386.

16. International, collaborations in cancer control and the Third international Cancer Control Congress. Timori Milan. 2009. Vol. 95. P. 579-596.

17. Jemal A., Siegel R., Ward E., et al. Cancer Statistics // Cancer J. Clin. 2007. Vol. 57. P. 43- 66.

18. Khazaei Z., Hasanpour D., Amiri M. et al. The incidence and mortality of endometrial cancer and its association with body mass index and human development index in Asian population. World Cancer Res J 2018;5:e1174.

19. Lancaster J.M., Powell C.B., Chen L.M., Richardson D.L. Society of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions. Gynecol Oncol. 2015; 136: 3-7. doi: 10.1016/j.ygyno.2014.09.009

20. NCCN Clinical Practice Guidelines in Oncology. Uterine Neoplasms; Version 2.2018 — may 25.2018 https://www.nccn.org/profession-als/physician_gls/pdf/uterine.pdf

21. Preserving fertility in young patients with endometrial cancer: current Kalogera E., Dowdy S.C., Bakkum-Gamez J.N. perspectives. Int J Womens Health. 2014; 6:691–701.

22. Prognostic factors for uterine cancer in reproductive-aged women. Obstet Gynecol. Lee N.K., Cheung M.K., Shin J.Y., et al. 2007;109(3):655-662.

23. Siegel RL, Miller KD, Siegel RL, Miller KD, Cancer statistics. CA Cancer J Clin. 2019; 69: 7-34

24. Suarez A.A., Felix A.S., Cohn D.E. (2017). Bokhman redux: Endometrial cancer “types” in the 21<sup>st</sup> century. Gynecol. Oncol., 144 (2), 243–249. doi: 10.1016/j.ygyno.2016.12.010.

25. Taylan E., Oktay K. Fertility preservation in gynecologic cancers // Gynecol. Oncol. 2019. Vol. 155 (3). P. 522–529. doi: 10.1016/j.ygyno.2019.09.012

26. Torre L.A., Farhad I., Siegel R.L., Ward E.M., Ahmedin J. Global cancer in women: burden and trends // Cancer Epidemiol. Biomarkers Prev. 2017. Vol. 26 (4). P. 444–457.

27. Wilczyński M., Danielska J., Wilczyński J. (2016). An update of the classical Bokhman’s dualistic model of endometrial cancer. Menopause Rev., 15 (2), 63-68. doi: 10.5114/pm.2016.61186.


Review

For citations:


Kirillova E.N., Nikolaeva T.I., Myreeva S.A., Sosina T.A. Organ-sparing treatment for early-stage endometrial cancer with reproductive function. Yakut Medical Journal. 2023;(2):131-134. https://doi.org/10.25789/YMJ.2023.82.32

Views: 39


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1813-1905 (Print)
ISSN 2312-1017 (Online)