Comparative evaluation of associations of VEGFA gene polymorphisms with the risk of malignancies of the female reproductive system: a meta-analysis

Comparative assessment of the association of rs2010963, rs699947 and rs3025039 polymorphisms of the VEGFA gene with the risk of developing malignant neoplasms of the female reproductive system was conducted using a meta-analysis method. A systematic literature search of domestic and international databases identified 15 case-control studies. A significant increase in the risk of female reproductive system cancers was associated with the minor alleles of VEGFA polymorphisms rs2010963 (OR = 1.24; 95% CI: 1.09–1.41; p = 0.0008) and rs699947 (OR = 1.16; 95% CI: 1.04–1.28; p = 0.0058). No such association was identified for rs3025039. The analysis indicated substantial heterogeneity among the included studies. The results of the meta-analysis confirm the role of VEGFA gene polymorphisms in modulating the risk of female reproductive system cancer and indicate the need to consider ethnic and nosological characteristics in further research.

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